Details of the Drug Combination

General Information of Drug Combination (ID: DCG5YAD)

• Drug Combination Name: DFN-15 + Vinflunine
• Indication: Childhood T acute lymphoblastic leukemia; Status: Investigative [1]
• Component Drugs:
  DFN-15 (DM3BF9B): N.A.
  Vinflunine (DMTJAEP): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: CCRF-CEM
  Zero Interaction Potency (ZIP) Score: 5.04
  Bliss Independence Score: 10.05
  Loewe Additivity Score: 4.49
  LHighest Single Agent (HSA) Score: 3.62

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult T acute lymphoblastic leukemia	DCUUQPO	MOLT-4	Investigative	[1]
Chronic myelogenous leukemia	DC98440	K-562	Investigative	[1]
Clear cell renal cell carcinoma	DC1ZLKQ	786-0	Investigative	[1]
Glioblastoma	DC7NT7W	SNB-75	Investigative	[1]
Plasma cell myeloma	DCZ7IPY	RPMI-8226	Investigative	[1]
Invasive ductal carcinoma	DCYHMLY	HS 578T	Investigative	[4]
Adenocarcinoma	DCMQNBG	OVCAR3	Investigative	[5]
Adenocarcinoma	DCGSSDF	NCIH23	Investigative	[5]
Cutaneous melanoma	DC7T3FR	SK-MEL-5	Investigative	[5]
Malignant melanoma	DCE0YDY	LOX IMVI	Investigative	[5]

References

• [1] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [2] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [3] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [4] Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
• [5] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.