Details of the Drug Combination

General Information of Drug Combination (ID: DCHCMTG)

Drug Combination Name

AS-1949490 Ibutilide

Indication

Disease Entry	Status	REF
Chronic myelogenous leukemia	Investigative	[1]

Component Drugs

AS-1949490 DMZ1OO0

Ibutilide DMKXY2R

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: KBM-7

Zero Interaction Potency (ZIP) Score: 3.35

Bliss Independence Score: 3.35

Loewe Additivity Score: 18.22

LHighest Single Agent (HSA) Score: 18.22

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of AS-1949490

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Investigative	[2]

Indication(s) of Ibutilide

Disease Entry	ICD 11	Status	REF
Atrial fibrillation	BC81.3	Approved	[3]

Ibutilide Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Potassium channel unspecific (KC)	TT1VOHK	NOUNIPROTAC	Modulator	[4]
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References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7200).
4	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.