Details of the Drug Combination

General Information of Drug Combination (ID: DCHX15Z)

Drug Combination Name
Arfolitixorin Leucovorin
Indication
Disease Entry Status REF
Osteosarcoma Phase 1 [1]
Component Drugs Arfolitixorin   DMIXMYK Leucovorin   DMUAZWG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Arfolitixorin
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 3 [2]
Indication(s) of Leucovorin
Disease Entry ICD 11 Status REF
Colon adenocarcinoma N.A. Approved [3]
Pervasive developmental disorder 6A00-6A0Z Approved [3]
Rectal adenocarcinoma 2B92 Approved [3]
Rectum mucinous adenocarcinoma N.A. Approved [3]
Colon cancer 2B90.Z Investigative [3]
Colon mucinous adenocarcinoma N.A. Investigative [3]
Megaloblastic anemia N.A. Investigative [3]
Methotrexate toxicity N.A. Investigative [3]
Leucovorin Interacts with 3 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Multidrug resistance-associated protein 2 (ABCC2) DTFI42L MRP2_HUMAN Substrate [4]
Multidrug resistance-associated protein 3 (ABCC3) DTQ3ZHF MRP3_HUMAN Substrate [5]
Multidrug resistance-associated protein 4 (ABCC4) DTCSGPB MRP4_HUMAN Substrate [6]
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References

1 ClinicalTrials.gov (NCT01987102) Investigation of [6R] 5,10-methylenetetrahydrofolate (Arfolitixorin) as Rescue Therapy for Osteosarcoma Patients Treated With HDMTX.
2 ClinicalTrials.gov (NCT03750786) A Study to Compare the Efficacy of Arfolitixorin Versus Leucovorin in Combination With 5 Fluorouracil, Oxaliplatin, and Bevacizumab in Patients With Advanced Colorectal Cancer (AGENT). U.S. National Institutes of Health.
3 Leucovorin FDA Label
4 Transport of methotrexate, methotrexate polyglutamates, and 17beta-estradiol 17-(beta-D-glucuronide) by ABCG2: effects of acquired mutations at R482 on methotrexate transport. Cancer Res. 2003 Jul 15;63(14):4048-54.
5 Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport. Cancer Res. 2001 Oct 1;61(19):7225-32.
6 Analysis of methotrexate and folate transport by multidrug resistance protein 4 (ABCC4): MRP4 is a component of the methotrexate efflux system. Cancer Res. 2002 Jun 1;62(11):3144-50.