Details of the Drug Combination

General Information of Drug Combination (ID: DCIXC8N)

Drug Combination Name
GSK-2256098 ONC201
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs GSK-2256098   DMR24MI ONC201   DMM5SCF
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 14.792
Bliss Independence Score: 24.759
Loewe Additivity Score: 1.092
LHighest Single Agent (HSA) Score: 1.929

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of GSK-2256098
Disease Entry ICD 11 Status REF
Pulmonary arterial hypertension BB01.0 Phase 1 [2]
Solid tumour/cancer 2A00-2F9Z Phase 1 [3]
GSK-2256098 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Focal adhesion kinase 1 (FAK) TTON5IT FAK1_HUMAN Inhibitor [5]
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Indication(s) of ONC201
Disease Entry ICD 11 Status REF
Endometrial cancer 2C76 Phase 2 [4]
Glioma 2A00.0 Phase 2 [4]
Multiple myeloma 2A83 Phase 2 [4]
Neuroendocrine cancer 2B72.1 Phase 2 [4]
Recurring respiratory infection CA07-CA45 Phase 2 [4]
leukaemia 2A60-2B33 Phase 1/2 [4]
Lymphoma 2A80-2A86 Phase 1/2 [4]
Solid tumour/cancer 2A00-2F9Z Phase 1 [4]
ONC201 Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Dopamine D3 receptor (D3R) TT4C8EA DRD3_HUMAN Antagonist [4]
Dopamine receptor (DR) TTWFZ1N NOUNIPROTAC Antagonist [6]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Antagonist [4]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7939).
4 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
5 A small molecule FAK kinase inhibitor, GSK2256098, inhibits growth and survival of pancreatic ductal adenocarcinoma cells. Cell Cycle. 2014;13(19):3143-9.
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)