General Information of Drug Combination (ID: DCJ0YEY)

Drug Combination Name
Amonafide DFN-15
Indication
Disease Entry Status REF
Chronic myelogenous leukemia Investigative [1]
Component Drugs Amonafide   DMAH59S DFN-15   DM3BF9B
Small molecular drug N.A.
High-throughput Screening Result Testing Cell Line: K-562
Zero Interaction Potency (ZIP) Score: 2.36
Bliss Independence Score: 5
Loewe Additivity Score: 4.3
LHighest Single Agent (HSA) Score: 7.5

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCGRDY0 A549 Investigative [1]
Adenocarcinoma DCY01FH HCT116 Investigative [1]
Clear cell renal cell carcinoma DC4UVDX 786-0 Investigative [1]
Lung adenocarcinoma DCDBEHC HOP-62 Investigative [1]
Renal cell carcinoma DCBQ1AC SN12C Investigative [1]
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References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 ClinicalTrials.gov (NCT00715637) Phase III Randomized Study of Amonafide (AS1413) and Cytarabine Versus Daunorubicin and Cytarabine in Patients With Secondary Acute Myeloid Leukemia (AML)- the ACCEDEStudy. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)