Details of the Drug Combination

General Information of Drug Combination (ID: DCJN49L)

Drug Combination Name
Trimegestone Ethinyl Estradiol
Indication
Disease Entry Status REF
Contraception Phase 1 [1]
Component Drugs Trimegestone   DMHSZ1V Ethinyl Estradiol   DMODJ40
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Trimegestone
Disease Entry ICD 11 Status REF
Hormone replacement therapy 8E01 Approved [2]
Indication(s) of Ethinyl Estradiol
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [3]
Female hypogonadism GA30.6 Approved [4]
Hot flushes GA30 Approved [3]
Obsolete atrophic vulva N.A. Approved [3]
Ethinyl Estradiol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Estrogen receptor (ESR) TTZAYWL ESR1_HUMAN Agonist [9]
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Ethinyl Estradiol Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [10]
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Ethinyl Estradiol Interacts with 6 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [11]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [12]
Cytochrome P450 1A1 (CYP1A1) DE6OQ3W CP1A1_HUMAN Metabolism [13]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [14]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [13]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [15]
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⏷ Show the Full List of 6 DME(s)
Ethinyl Estradiol Interacts with 280 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Decreases Activity [14]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Decreases Expression [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Hydroxylation [13]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Hydroxylation [13]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Increases Hydroxylation [13]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [10]
Sulfotransferase 1E1 (SULT1E1) OTGPJ517 ST1E1_HUMAN Decreases Activity [17]
Gamma-aminobutyric acid receptor subunit pi (GABRP) OTGKA8WS GBRP_HUMAN Decreases Expression [6]
Ectoderm-neural cortex protein 1 (ENC1) OTJEUB6U ENC1_HUMAN Decreases Expression [6]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1) OTFK8KDP NHRF1_HUMAN Increases Expression [6]
Neuropilin-1 (NRP1) OTCGULYV NRP1_HUMAN Increases Expression [6]
Transmembrane protease serine 2 (TMPRSS2) OTN44YQ5 TMPS2_HUMAN Decreases Expression [6]
Insulin-induced gene 1 protein (INSIG1) OTZF5X1D INSI1_HUMAN Increases Expression [6]
Krueppel-like factor 4 (KLF4) OT4O9RQW KLF4_HUMAN Increases Expression [6]
Band 4.1-like protein 2 (EPB41L2) OT6UABPM E41L2_HUMAN Increases Expression [6]
Tetraspanin-1 (TSPAN1) OTZQPIYK TSN1_HUMAN Decreases Expression [6]
Microfibrillar-associated protein 3-like (MFAP3L) OTNMHSAH MFA3L_HUMAN Increases Expression [6]
Short-chain dehydrogenase/reductase 3 (DHRS3) OTSK1DTP DHRS3_HUMAN Increases Expression [6]
Dysferlin (DYSF) OTNSKJU0 DYSF_HUMAN Decreases Expression [6]
Gamma-butyrobetaine dioxygenase (BBOX1) OTKEX4RK BODG_HUMAN Decreases Expression [6]
Nebulette (NEBL) OT2WH1NC NEBL_HUMAN Decreases Expression [6]
ATP-dependent DNA helicase Q5 (RECQL5) OTVZMP1Q RECQ5_HUMAN Decreases Expression [6]
Sorbin and SH3 domain-containing protein 2 (SORBS2) OTJSX44Y SRBS2_HUMAN Decreases Expression [6]
Serine protease 23 (PRSS23) OT6DQAM1 PRS23_HUMAN Decreases Expression [6]
NADH dehydrogenase 1 beta subcomplex subunit 6 (NDUFB6) OTIXNT91 NDUB6_HUMAN Increases Expression [6]
Rap guanine nucleotide exchange factor 3 (RAPGEF3) OTMOW4Z4 RPGF3_HUMAN Decreases Expression [6]
Secretoglobin family 1D member 2 (SCGB1D2) OTSYWZAQ SG1D2_HUMAN Increases Expression [6]
Aldehyde dehydrogenase 1A1 (ALDH1A1) OTCUWZKB AL1A1_HUMAN Decreases Expression [6]
Carbonic anhydrase 2 (CA2) OTJRMUAG CAH2_HUMAN Increases Expression [6]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [6]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Increases Expression [6]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [6]
N-myc proto-oncogene protein (MYCN) OTWD33K1 MYCN_HUMAN Decreases Expression [6]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA) OTWJTCRK PCCA_HUMAN Increases Expression [6]
Alkaline phosphatase, placental type (ALPP) OTZU4G9W PPB1_HUMAN Increases Expression [6]
Collagen alpha-2(V) chain (COL5A2) OT5VOSQE CO5A2_HUMAN Decreases Expression [6]
Progesterone receptor (PGR) OT0FZ3QE PRGR_HUMAN Increases Expression [6]
Thrombospondin-1 (THBS1) OT0ECWK3 TSP1_HUMAN Increases Expression [6]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [6]
Interleukin-6 receptor subunit alpha (IL6R) OTCQL07Z IL6RA_HUMAN Increases Expression [6]
Matrilysin (MMP7) OTVT3SEJ MMP7_HUMAN Increases Expression [6]
Stromelysin-2 (MMP10) OTJDWW8Q MMP10_HUMAN Decreases Expression [6]
Retinol-binding protein 1 (RBP1) OTRP1MFC RET1_HUMAN Decreases Expression [6]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Decreases Expression [6]
Interferon alpha-inducible protein 6 (IFI6) OTWOOAM4 IFI6_HUMAN Decreases Expression [6]
Alkaline phosphatase, germ cell type (ALPG) OTCIM29R PPBN_HUMAN Increases Expression [6]
Creatine kinase B-type (CKB) OTUCKOTT KCRB_HUMAN Increases Expression [6]
Insulin-like growth factor-binding protein 3 (IGFBP3) OTIX63TX IBP3_HUMAN Decreases Expression [6]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [6]
Endothelin-2 (EDN2) OTQ7RCPI EDN2_HUMAN Decreases Expression [6]
Collagen alpha-1(V) chain (COL5A1) OT24078H CO5A1_HUMAN Increases Expression [6]
Fibroblast growth factor receptor 2 (FGFR2) OTLOPACK FGFR2_HUMAN Decreases Expression [6]
Galanin peptides (GAL) OTB3VPTO GALA_HUMAN Increases Expression [6]
Fibroblast growth factor receptor 3 (FGFR3) OTSAXDIL FGFR3_HUMAN Decreases Expression [6]
cAMP-dependent protein kinase catalytic subunit beta (PRKACB) OT6RMDCE KAPCB_HUMAN Affects Expression [6]
Prostaglandin G/H synthase 1 (PTGS1) OTHCRLEC PGH1_HUMAN Decreases Expression [6]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [6]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Decreases Expression [6]
Transcription factor HIVEP2 (HIVEP2) OTVOMCW4 ZEP2_HUMAN Decreases Expression [6]
Sodium- and chloride-dependent taurine transporter (SLC6A6) OT67U7G3 SC6A6_HUMAN Decreases Expression [6]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [6]
Activin receptor type-1B (ACVR1B) OT778HIQ ACV1B_HUMAN Decreases Expression [6]
Collagen alpha-1(XV) chain (COL15A1) OTTFKK18 COFA1_HUMAN Increases Expression [6]
Replication factor C subunit 3 (RFC3) OT1MS7AO RFC3_HUMAN Increases Expression [6]
Exosome RNA helicase MTR4 (MTREX) OTSQY30V MTREX_HUMAN Increases Expression [6]
G protein-activated inward rectifier potassium channel 1 (KCNJ3) OTHQG16J KCNJ3_HUMAN Decreases Expression [6]
Retinol-binding protein 2 (RBP2) OTR8QG5V RET2_HUMAN Decreases Expression [6]
LIM domain kinase 2 (LIMK2) OTRJD7VZ LIMK2_HUMAN Decreases Expression [6]
ADP-ribosylation factor 3 (ARF3) OTYYQX85 ARF3_HUMAN Decreases Expression [6]
Transforming growth factor beta-2 proprotein (TGFB2) OTC0TXEP TGFB2_HUMAN Decreases Expression [6]
Phosphoserine phosphatase (PSPH) OTV1PVAX SERB_HUMAN Decreases Expression [6]
Protein jagged-1 (JAG1) OT3LGT6K JAG1_HUMAN Decreases Expression [6]
4-aminobutyrate aminotransferase, mitochondrial (ABAT) OTXAGR7J GABT_HUMAN Decreases Expression [6]
Low-density lipoprotein receptor-related protein 2 (LRP2) OTZ6W681 LRP2_HUMAN Decreases Expression [6]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Increases Expression [6]
Cyclic AMP-responsive element-binding protein 5 (CREB5) OTJDUJPI CREB5_HUMAN Increases Expression [6]
Transcription factor SOX-4 (SOX4) OTSS40SS SOX4_HUMAN Decreases Expression [6]
Amino acid transporter heavy chain SLC3A1 (SLC3A1) OT56V01A SLC31_HUMAN Decreases Expression [6]
Cadherin-18 (CDH18) OTC06P9H CAD18_HUMAN Decreases Expression [6]
Calcyphosin (CAPS) OTC9GZ2M CAYP1_HUMAN Increases Expression [6]
Transcription factor Dp-2 (TFDP2) OTKQFX5H TFDP2_HUMAN Decreases Expression [6]
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) OTKUW1WT PDE3A_HUMAN Decreases Expression [6]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Decreases Expression [6]
Pericentriolar material 1 protein (PCM1) OTFM133C PCM1_HUMAN Decreases Expression [6]
Neutral amino acid transporter B(0) (SLC1A5) OTE2H26Q AAAT_HUMAN Increases Expression [6]
Adiponectin (ADIPOQ) OTNX23LE ADIPO_HUMAN Decreases Expression [6]
Dual specificity protein phosphatase 5 (DUSP5) OTH96RA7 DUS5_HUMAN Increases Expression [6]
Protein Dok-7 (DOK7) OTR2V7HO DOK7_HUMAN Increases Expression [6]
Protein GREB1 (GREB1) OTU6ZA26 GREB1_HUMAN Increases Expression [6]
Piercer of microtubule wall 1 protein (PIERCE1) OTONT0CN PIRC1_HUMAN Decreases Expression [6]
Retrotransposon Gag-like protein 5 (RTL5) OT9ZJR3N RTL5_HUMAN Decreases Expression [6]
Protein phosphatase 1J (PPM1J) OTM6GDJJ PPM1J_HUMAN Increases Expression [6]
Immediate early response gene 5-like protein (IER5L) OT6IG629 IER5L_HUMAN Increases Expression [6]
Disabled homolog 2-interacting protein (DAB2IP) OTF456VC DAB2P_HUMAN Affects Expression [6]
Muscleblind-like protein 2 (MBNL2) OTF7CF1F MBNL2_HUMAN Decreases Expression [6]
Anoctamin-1 (ANO1) OTSREUNI ANO1_HUMAN Increases Expression [6]
Proline-rich membrane anchor 1 (PRIMA1) OT9ITT3P PRIMA_HUMAN Decreases Expression [6]
Prolyl 3-hydroxylase 2 (P3H2) OTY84H6U P3H2_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase TRIM22 (TRIM22) OTJBLG5R TRI22_HUMAN Decreases Expression [6]
Solute carrier family 25 member 45 (SLC25A45) OTP7EAUM S2545_HUMAN Decreases Expression [6]
PACRG-like protein (PACRGL) OT5DEP0X PACRL_HUMAN Increases Expression [6]
N-acetylaspartate synthetase (NAT8L) OTA96AVN NAT8L_HUMAN Decreases Expression [6]
Retinoic acid-induced protein 3 (GPRC5A) OTPOCWR7 RAI3_HUMAN Decreases Expression [6]
Two pore channel protein 2 (TPCN2) OTLAF3ED TPC2_HUMAN Decreases Expression [6]
LIM domain only protein 3 (LMO3) OTR7AJHN LMO3_HUMAN Decreases Expression [6]
DEP domain-containing mTOR-interacting protein (DEPTOR) OTCBP1BT DPTOR_HUMAN Increases Expression [6]
Epidermal growth factor receptor kinase substrate 8-like protein 1 (EPS8L1) OT83O8WI ES8L1_HUMAN Decreases Expression [6]
Complexin-3 (CPLX3) OT0YTMN2 CPLX3_HUMAN Decreases Expression [6]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [6]
Protein kinase C-binding protein NELL1 (NELL1) OTF3TX3N NELL1_HUMAN Decreases Expression [6]
LIM/homeobox protein Lhx4 (LHX4) OTVX3J6S LHX4_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase MIB2 (MIB2) OTJCC3HS MIB2_HUMAN Decreases Expression [6]
Dedicator of cytokinesis protein 10 (DOCK10) OTI3MBLV DOC10_HUMAN Decreases Expression [6]
Galactose mutarotase (GALM) OT7UPL4D GALM_HUMAN Decreases Expression [6]
Endoplasmic reticulum resident protein 27 (ERP27) OTVMGE2H ERP27_HUMAN Decreases Expression [6]
Hedgehog-interacting protein (HHIP) OT77RQYS HHIP_HUMAN Decreases Expression [6]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Decreases Expression [6]
Neurturin (NRTN) OT4PAKUY NRTN_HUMAN Increases Expression [6]
Ras-like protein family member 11B (RASL11B) OTHEVZS6 RSLBB_HUMAN Decreases Expression [6]
Mitochondrial ribosome-associated GTPase 1 (MTG1) OTC9U1LI MTG1_HUMAN Decreases Expression [6]
Melanophilin (MLPH) OT7ADCXL MELPH_HUMAN Increases Expression [6]
RNA-binding protein 24 (RBM24) OTQI1AR1 RBM24_HUMAN Increases Expression [6]
Keratin-associated protein 2-1 (KRTAP2-1) OTV1SGF2 KRA21_HUMAN Decreases Expression [6]
Keratin, type I cytoskeletal 23 (KRT23) OTQW6UAG K1C23_HUMAN Decreases Expression [6]
Cysteine-rich secretory protein LCCL domain-containing 1 (CRISPLD1) OT38HXJP CRLD1_HUMAN Increases Expression [6]
Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) OTAQD3YV ARNT2_HUMAN Decreases Expression [6]
Plexin-A4 (PLXNA4) OT5XKB3Q PLXA4_HUMAN Decreases Expression [6]
Palmdelphin (PALMD) OTRLOZ4Y PALMD_HUMAN Decreases Expression [6]
Transcription and mRNA export factor ENY2 (ENY2) OTTNU8RK ENY2_HUMAN Decreases Expression [6]
Signal peptide, CUB and EGF-like domain-containing protein 2 (SCUBE2) OT661S7D SCUB2_HUMAN Decreases Expression [6]
Cytochrome P450 26B1 (CYP26B1) OT92XA92 CP26B_HUMAN Decreases Expression [6]
Olfactomedin-like protein 3 (OLFML3) OTDN45FN OLFL3_HUMAN Increases Expression [6]
Cytokine-inducible SH2-containing protein (CISH) OT8T5NYL CISH_HUMAN Increases Expression [6]
ATPase family AAA domain-containing protein 3A (ATAD3A) OTWF6HBP ATD3A_HUMAN Decreases Expression [6]
Kv channel-interacting protein 1 (KCNIP1) OTGLGK1R KCIP1_HUMAN Decreases Expression [6]
Denticleless protein homolog (DTL) OTC29RYE DTL_HUMAN Increases Expression [6]
Peroxisomal sarcosine oxidase (PIPOX) OTWTCOTN SOX_HUMAN Increases Expression [6]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) OTV3Q0DS ATS9_HUMAN Increases Expression [6]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A) OTHCDQ22 PRGC1_HUMAN Decreases Expression [6]
Dickkopf-related protein 3 (DKK3) OTDU94EY DKK3_HUMAN Decreases Expression [6]
Protein NDRG2 (NDRG2) OT5L6KD7 NDRG2_HUMAN Decreases Expression [6]
Rho family-interacting cell polarization regulator 2 (RIPOR2) OTXB6LIR RIPR2_HUMAN Decreases Expression [6]
Transcription factor HES-2 (HES2) OTMWY2KV HES2_HUMAN Increases Expression [6]
Tolloid-like protein 2 (TLL2) OTHZ4TBL TLL2_HUMAN Increases Expression [6]
Metallothionein-2 (MT2A) OTHOACHD MT2_HUMAN Increases Expression [16]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Affects Activity [16]
S-adenosylhomocysteine hydrolase-like protein 1 (AHCYL1) OTX8L3M5 SAHH2_HUMAN Affects Expression [7]
Putative hydrolase DDAH2 (DDAH2) OT8Q40G2 DDAH2_HUMAN Affects Expression [7]
Integrin beta-3 (ITGB3) OTWCK1K6 ITB3_HUMAN Affects Expression [7]
Small integral membrane protein 6 (SMIM6) OTRGL3O1 SMIM6_HUMAN Affects Expression [7]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Affects Expression [7]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Affects Expression [7]
Deoxyribonuclease-1 (DNASE1) OTM4KWB3 DNAS1_HUMAN Affects Expression [7]
G0/G1 switch protein 2 (G0S2) OT8FL49L G0S2_HUMAN Affects Expression [7]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Affects Expression [7]
Homeobox protein MOX-1 (MEOX1) OTJEMT2D MEOX1_HUMAN Affects Expression [7]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Affects Expression [7]
Cadherin-6 (CDH6) OT81Y80S CADH6_HUMAN Affects Expression [7]
Phospholipid-transporting ATPase ID (ATP8B2) OTH5WJ09 AT8B2_HUMAN Affects Expression [7]
Transgelin (TAGLN) OTAEZ0KP TAGL_HUMAN Affects Expression [7]
Programmed cell death protein 4 (PDCD4) OTZ6NXUX PDCD4_HUMAN Affects Expression [7]
Sclerostin domain-containing protein 1 (SOSTDC1) OTAKDNSM SOSD1_HUMAN Affects Expression [7]
Transmembrane protein 64 (TMEM64) OTO9IDFD TMM64_HUMAN Affects Expression [7]
Echinoderm microtubule-associated protein-like 6 (EML6) OTE1MUQS EMAL6_HUMAN Affects Expression [7]
PX domain-containing protein kinase-like protein (PXK) OTSP1WLK PXK_HUMAN Affects Expression [7]
Protein limb expression 1 homolog (LIX1) OT1CPNCC LIX1_HUMAN Affects Expression [7]
Uncharacterized protein FAM241A (FAM241A) OTC12ETA F241A_HUMAN Affects Expression [7]
RalBP1-associated Eps domain-containing protein 2 (REPS2) OTSE3TRP REPS2_HUMAN Affects Expression [7]
Syntaxin-binding protein 6 (STXBP6) OTUEKTIP STXB6_HUMAN Affects Expression [7]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Affects Expression [7]
Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12) OT0EDNV9 GTR12_HUMAN Affects Expression [7]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Affects Expression [7]
Peroxidasin homolog (PXDN) OTFGGM9R PXDN_HUMAN Affects Expression [7]
Secreted frizzled-related protein 3 (FRZB) OTTO3DPY SFRP3_HUMAN Affects Expression [7]
DNA endonuclease RBBP8 (RBBP8) OTRHJ3GI CTIP_HUMAN Affects Expression [7]
Transmembrane protease serine 4 (TMPRSS4) OTCCGY2K TMPS4_HUMAN Affects Expression [7]
Cdc42 effector protein 3 (CDC42EP3) OTUZ3U9Z BORG2_HUMAN Affects Expression [7]
Teneurin-1 (TENM1) OTSKSU4V TEN1_HUMAN Affects Expression [7]
RNA polymerase II elongation factor ELL2 (ELL2) OTZJRTFM ELL2_HUMAN Affects Expression [8]
Mothers against decapentaplegic homolog 6 (SMAD6) OTUZZWUD SMAD6_HUMAN Affects Expression [8]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Increases Activity [18]
RAS guanyl-releasing protein 1 (RASGRP1) OTX9WN2E GRP1_HUMAN Affects Expression [8]
Bile salt export pump (ABCB11) OTRU7THO ABCBB_HUMAN Decreases Expression [19]
Cytochrome c oxidase subunit 3 (COX3) OTNNGBYJ COX3_HUMAN Increases Expression [20]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Increases Expression [21]
Plasminogen (PLG) OTWWIPPY PLMN_HUMAN Increases Expression [22]
Renin (REN) OT52GZR2 RENI_HUMAN Increases Activity [23]
ATP synthase subunit a (ATP6) OTPHOGLX ATP6_HUMAN Increases Expression [20]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Decreases Activity [22]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Increases Expression [23]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Increases Expression [24]
Follitropin subunit beta (FSHB) OTGLS283 FSHB_HUMAN Decreases Expression [25]
Lutropin subunit beta (LHB) OT5GBOVJ LSHB_HUMAN Decreases Activity [26]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [25]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Expression [27]
C-reactive protein (CRP) OT0RFT8F CRP_HUMAN Increases Expression [28]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Increases Expression [29]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [30]
Histidine-rich glycoprotein (HRG) OTPLUFOG HRG_HUMAN Decreases Expression [31]
Sex hormone-binding globulin (SHBG) OTPWU5IW SHBG_HUMAN Increases Expression [32]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Affects Activity [33]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [25]
Endothelin-1 (EDN1) OTZCACEG EDN1_HUMAN Affects Expression [8]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Affects Expression [34]
Thrombomodulin (THBD) OT8VHLKY TRBM_HUMAN Decreases Expression [21]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Decreases Expression [22]
Transcription factor Sp1 (SP1) OTISPT4X SP1_HUMAN Increases Activity [35]
Asparagine synthetase (ASNS) OT8R922G ASNS_HUMAN Affects Expression [8]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Increases Expression [21]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Affects Expression [8]
Chromogranin-A (CHGA) OTXYX5JH CMGA_HUMAN Affects Expression [8]
Serine/threonine-protein kinase pim-1 (PIM1) OTWEKXTU PIM1_HUMAN Affects Expression [8]
Keratin, type II cytoskeletal 5 (KRT5) OTVGI9HT K2C5_HUMAN Affects Expression [8]
Beta-1,4-galactosyltransferase 1 (B4GALT1) OTBCXEK7 B4GT1_HUMAN Increases Expression [36]
Fos-related antigen 1 (FOSL1) OT9YTYMB FOSL1_HUMAN Affects Expression [8]
Gap junction alpha-1 protein (GJA1) OTT94MKL CXA1_HUMAN Increases Expression [37]
Insulin-like growth factor-binding protein 2 (IGFBP2) OTG1P60E IBP2_HUMAN Decreases Expression [27]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [38]
Myelin and lymphocyte protein (MAL) OTBM30SW MAL_HUMAN Affects Expression [8]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [27]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Activity [39]
Insulin-like growth factor-binding protein complex acid labile subunit (IGFALS) OTTWCZYM ALS_HUMAN Decreases Expression [25]
ETS translocation variant 5 (ETV5) OTE2OBM4 ETV5_HUMAN Affects Expression [8]
Radiation-inducible immediate-early gene IEX-1 (IER3) OTZJI5FZ IEX1_HUMAN Affects Expression [8]
Solute carrier organic anion transporter family member 1A2 (SLCO1A2) OTO70C5O SO1A2_HUMAN Decreases Expression [19]
Stromal cell-derived factor 1 (CXCL12) OT2QX5LL SDF1_HUMAN Increases Expression [40]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Affects Expression [8]
Glutamate--cysteine ligase catalytic subunit (GCLC) OTESDI4D GSH1_HUMAN Affects Expression [8]
Cysteine--tRNA ligase, cytoplasmic (CARS1) OTOUZF6O SYCC_HUMAN Affects Expression [8]
Serine--tRNA ligase, cytoplasmic (SARS1) OTFKXQ1O SYSC_HUMAN Affects Expression [8]
CCAAT/enhancer-binding protein delta (CEBPD) OTNBIPMY CEBPD_HUMAN Affects Expression [8]
Inhibin beta E chain (INHBE) OTOI2NYG INHBE_HUMAN Affects Expression [8]
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN (PTEN) OTOWDUNT PTEN_HUMAN Affects Expression [8]
Transformer-2 protein homolog beta (TRA2B) OTZYQW52 TRA2B_HUMAN Increases Expression [41]
Small ribosomal subunit protein RACK1 (RACK1) OTZBCQ1U RACK1_HUMAN Increases Expression [42]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Expression [43]
Schlafen family member 5 (SLFN5) OTT1AESL SLFN5_HUMAN Affects Expression [8]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Affects Expression [8]
Four and a half LIM domains protein 2 (FHL2) OT0OAYWT FHL2_HUMAN Affects Expression [8]
Hepatic sodium/bile acid cotransporter (SLC10A1) OTUJVMCL NTCP_HUMAN Decreases Expression [19]
Nuclear receptor subfamily 1 group I member 3 (NR1I3) OTS3SGH7 NR1I3_HUMAN Increases Activity [44]
Advanced glycosylation end product-specific receptor (AGER) OTPY0IH7 RAGE_HUMAN Increases Expression [35]
Erythroferrone (ERFE) OTSES1HA ERFE_HUMAN Affects Expression [8]
FYVE, RhoGEF and PH domain-containing protein 3 (FGD3) OTIH6283 FGD3_HUMAN Affects Expression [8]
Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (PDZK1) OTGFK4MH NHRF3_HUMAN Increases Expression [36]
Early estrogen-induced gene 1 protein (EEIG1) OT2BMEAE EEIG1_HUMAN Increases Expression [36]
Very-long-chain (HACD2) OTAZO9F6 HACD2_HUMAN Affects Expression [8]
Retrotransposon-derived protein PEG10 (PEG10) OTWD2278 PEG10_HUMAN Affects Expression [8]
Ly6/PLAUR domain-containing protein 1 (LYPD1) OT0HSGML LYPD1_HUMAN Affects Expression [8]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Affects Splicing [41]
Stonin-2 (STON2) OT01JHHE STON2_HUMAN Affects Expression [8]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Affects Expression [8]
Estrogen receptor beta (ESR2) OTXNR2WQ ESR2_HUMAN Increases Activity [45]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Decreases Expression [19]
Tumor protein p53-inducible nuclear protein 1 (TP53INP1) OT2363Z9 T53I1_HUMAN Affects Expression [8]
Mediator of RNA polymerase II transcription subunit 8 (MED8) OTSIZ1I7 MED8_HUMAN Affects Expression [8]
Bile acid receptor (NR1H4) OTWZLPTB NR1H4_HUMAN Decreases Expression [19]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Affects Expression [8]
G-protein coupled estrogen receptor 1 (GPER1) OTUK0TDC GPER1_HUMAN Increases Expression [29]
Angiotensin-converting enzyme 2 (ACE2) OTTRZGU7 ACE2_HUMAN Decreases Expression [46]
Protein associated with UVRAG as autophagy enhancer (RUBCNL) OTMQIDOI PACER_HUMAN Affects Expression [8]
Tetratricopeptide repeat protein 12 (TTC12) OTDB24YV TTC12_HUMAN Affects Expression [8]
Solute carrier family 40 member 1 (SLC40A1) OT8RV2VY S40A1_HUMAN Affects Expression [8]
Matrix-remodeling-associated protein 5 (MXRA5) OTXZBWCU MXRA5_HUMAN Affects Expression [8]
Signal-induced proliferation-associated 1-like protein 2 (SIPA1L2) OT8NJE5D SI1L2_HUMAN Affects Expression [8]
Kelch-like protein 14 (KLHL14) OTYOS55H KLH14_HUMAN Affects Expression [8]
Transcription factor MafF (MAFF) OT9B7MX0 MAFF_HUMAN Affects Expression [8]
Cystine/glutamate transporter (SLC7A11) OTKJ6PXW XCT_HUMAN Affects Expression [8]
Proton-coupled zinc antiporter SLC30A1 (SLC30A1) OTY8J0S4 ZNT1_HUMAN Affects Expression [8]
SET-binding protein (SETBP1) OTKGCOSR SETBP_HUMAN Affects Expression [8]
Sulfotransferase 2A1 (SULT2A1) OT0ISKQ4 ST2A1_HUMAN Increases Metabolism [47]
Sulfotransferase 1A1 (SULT1A1) OT0K7JIE ST1A1_HUMAN Increases Metabolism [47]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Uptake [48]
Cytochrome P450 (CYP2B) OTDDG81I Q14097_HUMAN Increases ADR [49]
Sulfotransferase 1B1 (SULT1B1) OTH0RQYA ST1B1_HUMAN Increases Metabolism [47]
Sulfotransferase 1A3 (SULT1A4) OTHJ8WWV ST1A3_HUMAN Increases Sulfation [50]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Increases Hydroxylation [13]
Fibroblast growth factor 4 (FGF4) OTNVV3ZG FGF4_HUMAN Increases ADR [49]
Cytochrome P450 2B6 (CYP2B6) OTOYO4S7 CP2B6_HUMAN Affects Metabolism [51]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Hydroxylation [13]
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References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800016303)
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 Ethinyl estradiol FDA Label
4 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7071).
5 Characterization of the UDP glucuronosyltransferase activity of human liver microsomes genotyped for the UGT1A1*28 polymorphism. Drug Metab Dispos. 2007 Dec;35(12):2270-80.
6 The genomic response of a human uterine endometrial adenocarcinoma cell line to 17alpha-ethynyl estradiol. Toxicol Sci. 2009 Jan;107(1):40-55.
7 Dose- and time-dependent transcriptional response of Ishikawa cells exposed to genistein. Toxicol Sci. 2016 May;151(1):71-87.
8 The genomic response of Ishikawa cells to bisphenol A exposure is dose- and time-dependent. Toxicology. 2010 Apr 11;270(2-3):137-49. doi: 10.1016/j.tox.2010.02.008. Epub 2010 Feb 17.
9 17alpha-Ethinylestradiol hinders nucleotide excision repair in zebrafish liver cells. Aquat Toxicol. 2009 Dec 13;95(4):273-8.
10 P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.
11 Rifampicin, a keystone inducer of drug metabolism: from Herbert Remmer's pioneering ideas to modern concepts. Drug Metab Rev. 2004 Oct;36(3-4):497-509.
12 Drug-drug interactions for UDP-glucuronosyltransferase substrates: a pharmacokinetic explanation for typically observed low exposure (AUCi/AUC) ratios. Drug Metab Dispos. 2004 Nov;32(11):1201-8.
13 The involvement of CYP3A4 and CYP2C9 in the metabolism of 17 alpha-ethinylestradiol. Drug Metab Dispos. 2004 Nov;32(11):1209-12.
14 Examination of 209 drugs for inhibition of cytochrome P450 2C8. J Clin Pharmacol. 2005 Jan;45(1):68-78.
15 The effect of ethinyloestradiol and levonorgestrel on the CYP2C19-mediated metabolism of omeprazole in healthy female subjects. Br J Clin Pharmacol. 2003 Aug;56(2):232-7.
16 The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol. Arch Toxicol. 2013 Apr;87(4):633-43.
17 Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase. Anal Biochem. 2006 Oct 1;357(1):85-92.
18 Development of a common carp (Cyprinus carpio) pregnane X receptor (cPXR) transactivation reporter assay and its activation by azole fungicides and pharmaceutical chemicals. Toxicol In Vitro. 2017 Jun;41:114-122. doi: 10.1016/j.tiv.2017.02.023. Epub 2017 Mar 1.
19 UDCA and CDCA alleviate 17-ethinylestradiol-induced cholestasis through PKA-AMPK pathways in rats. Toxicol Appl Pharmacol. 2016 Nov 15;311:12-25. doi: 10.1016/j.taap.2016.10.011. Epub 2016 Oct 12.
20 Enhanced levels of several mitochondrial mRNA transcripts and mitochondrial superoxide production during ethinyl estradiol-induced hepatocarcinogenesis and after estrogen treatment of HepG2 cells. Carcinogenesis. 1998 Dec;19(12):2187-93. doi: 10.1093/carcin/19.12.2187.
21 Increased levels of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives. Thromb Haemost. 1996 Nov;76(5):729-34.
22 Effects of oral and transvaginal ethinyl estradiol on hemostatic factors and hepatic proteins in a randomized, crossover study. J Clin Endocrinol Metab. 2007 Jun;92(6):2074-9. doi: 10.1210/jc.2007-0026. Epub 2007 Mar 20.
23 Influence of the M235T polymorphism of human angiotensinogen (AGT) on plasma AGT and renin concentrations after ethinylestradiol administration. J Clin Endocrinol Metab. 2000 Nov;85(11):4331-7. doi: 10.1210/jcem.85.11.6932.
24 Study of low-density lipoprotein receptor regulation by oral (steroid) contraceptives: desogestrel, levonorgestrel and ethinyl estradiol in JEG-3 cell line and placental tissue. Contraception. 2007 Oct;76(4):297-305. doi: 10.1016/j.contraception.2007.06.011. Epub 2007 Sep 14.
25 Estrogens exert route- and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex. J Clin Endocrinol Metab. 2000 May;85(5):1918-22. doi: 10.1210/jcem.85.5.6527.
26 Estrogenic Compounds or Adiponectin Inhibit Cyclic AMP Response to Human Luteinizing Hormone in Mouse Leydig Tumor Cells. Biology (Basel). 2019 Jun 11;8(2):45. doi: 10.3390/biology8020045.
27 Ethinylestradiol and testosterone have divergent effects on circulating IGF system components in adolescents with constitutional tall stature. Eur J Endocrinol. 2005 Apr;152(4):597-604. doi: 10.1530/eje.1.01880.
28 Oral ethinyl estradiol, but not transdermal 17beta-estradiol, increases plasma C-reactive protein levels in men. Thromb Haemost. 2000 Aug;84(2):359-60.
29 Prediction of the combined effects of multiple estrogenic chemicals on MCF-7 human breast cancer cells and a preliminary molecular exploration of the estrogenic proliferative effects and related gene expression. Ecotoxicol Environ Saf. 2018 Sep 30;160:1-9. doi: 10.1016/j.ecoenv.2018.05.025. Epub 2018 May 21.
30 Evaluation of an imaging-based in vitro screening platform for estrogenic activity with OECD reference chemicals. Toxicol In Vitro. 2022 Jun;81:105348. doi: 10.1016/j.tiv.2022.105348. Epub 2022 Mar 18.
31 Estrogens reduce plasma histidine-rich glycoprotein (HRG) levels in a dose-dependent way. Thromb Haemost. 1995 Mar;73(3):484-7.
32 Oral contraceptives moderately effect bone resorption markers and serum-soluble interleukin-6 receptor concentrations. Calcif Tissue Int. 2002 Jan;70(1):11-21. doi: 10.1007/s002230020035. Epub 2001 Dec 21.
33 Identification of environmental chemicals that activate p53 signaling after in vitro metabolic activation. Arch Toxicol. 2022 Jul;96(7):1975-1987. doi: 10.1007/s00204-022-03291-5. Epub 2022 Apr 18.
34 Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity. Toxicology. 2014 Jun 5;320:46-55. doi: 10.1016/j.tox.2014.03.007. Epub 2014 Mar 28.
35 Differential effect of estrogen receptor alpha and beta agonists on the receptor for advanced glycation end product expression in human microvascular endothelial cells. Biochim Biophys Acta. 2005 Sep 30;1745(3):300-9. doi: 10.1016/j.bbamcr.2005.03.012. Epub 2005 Apr 12.
36 Identification of estrogen-responsive genes by complementary deoxyribonucleic acid microarray and characterization of a novel early estrogen-induced gene: EEIG1. Mol Endocrinol. 2004 Feb;18(2):402-11. doi: 10.1210/me.2003-0202. Epub 2003 Nov 6.
37 Increased expression of estrogen receptor beta in human uterine smooth muscle at term. Eur J Endocrinol. 2000 Jan;142(1):92-9. doi: 10.1530/eje.0.1420092.
38 Estradiol upregulates activating transcription factor 3, a candidate gene in the etiology of hypospadias. Pediatr Dev Pathol. 2007 Nov-Dec;10(6):446-54. doi: 10.2350/06-04-0079.1.
39 Synthetic estrogen-mediated activation of ERK 2 intracellular signaling molecule. Gynecol Endocrinol. 2003 Oct;17(5):423-8. doi: 10.1080/09513590312331290338.
40 Novel full logistic model for estimation of the estrogenic activity of chemical mixtures. Toxicology. 2016 Jun 1;359-360:58-70. doi: 10.1016/j.tox.2016.06.017. Epub 2016 Jun 29.
41 Regulation of alternative splicing of liver scavenger receptor class B gene by estrogen and the involved regulatory splicing factors. Endocrinology. 2007 Nov;148(11):5295-304. doi: 10.1210/en.2007-0376. Epub 2007 Aug 2.
42 Effects of endocrine disrupting chemicals on the expression of RACK1 and LPS-induced THP-1 cell activation. Toxicology. 2022 Oct;480:153321. doi: 10.1016/j.tox.2022.153321. Epub 2022 Sep 13.
43 Detection of MDM2 alterations in cultured human hepatocytes treated with 17beta-estradiol or 17alpha-ethinylestradiol. Anticancer Res. 2002 May-Jun;22(3):1545-51.
44 Agonistic effects of diverse xenobiotics on the constitutive androstane receptor as detected in a recombinant yeast-cell assay. Toxicol In Vitro. 2018 Feb;46:335-349. doi: 10.1016/j.tiv.2017.09.014. Epub 2017 Sep 18.
45 Comparison of in vivo and in vitro reporter gene assays for short-term screening of estrogenic activity. Environ Sci Technol. 2002 Oct 15;36(20):4410-5. doi: 10.1021/es010323a.
46 Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Arch Toxicol. 2020 Dec;94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. Epub 2020 Aug 17.
47 Sulfation of environmental estrogen-like chemicals by human cytosolic sulfotransferases. Biochem Biophys Res Commun. 2000 Jan 7;267(1):80-4. doi: 10.1006/bbrc.1999.1935.
48 Transport of ethinylestradiol glucuronide and ethinylestradiol sulfate by the multidrug resistance proteins MRP1, MRP2, and MRP3. J Pharmacol Exp Ther. 2004 Apr;309(1):156-64. doi: 10.1124/jpet.103.062091. Epub 2004 Jan 13.
49 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
50 Sulfotransferase 1E1 is a low km isoform mediating the 3-O-sulfation of ethinyl estradiol. Drug Metab Dispos. 2004 Nov;32(11):1299-303. doi: 10.1124/dmd.32.11..
51 Identification of 17-alpha-ethynylestradiol-modified active site peptides and glutathione conjugates formed during metabolism and inactivation of P450s 2B1 and 2B6. Chem Res Toxicol. 2006 Feb;19(2):279-87. doi: 10.1021/tx050256o.