Details of the Drug Combination

General Information of Drug Combination (ID: DCLUHB4)

Drug Combination Name

Valproic Acid Cefmenoxime

Indication

Disease Entry	Status	REF
Chronic myelogenous leukemia	Investigative	[1]

Component Drugs

Valproic Acid DMS49KH

Cefmenoxime DMPLY7B

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: KBM-7

Zero Interaction Potency (ZIP) Score: 18.28

Bliss Independence Score: 18.28

Loewe Additivity Score: 33.04

LHighest Single Agent (HSA) Score: 33.04

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Valproic Acid

Disease Entry	ICD 11	Status	REF
Absence epilepsy	N.A.	Approved	[2]
Epilepsy	8A60-8A68	Approved	[2]
Glioblastoma	2A00	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[3]
Neuroblastoma	2D11.2	Investigative	[2]

Indication(s) of Cefmenoxime

Disease Entry	ICD 11	Status	REF
Bacterial infection	1A00-1C4Z	Approved	[4]

Cefmenoxime Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Bacterial Penicillin binding protein 3 (Bact mrcA)	TT85JMW	FTSI_ECOLI	Binder	[5]
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References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	Valproic Acid FDA Label
3	Immunopharmacological management of COVID-19: Potential therapeutic role of valproic acid. Med Hypotheses. 2020 May 27;143:109891.
4	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
5	In vitro evaluation of E1040, a new cephalosporin with potent antipseudomonal activity. Antimicrob Agents Chemother. 1988 May;32(5):693-701.