Details of the Drug Combination

General Information of Drug Combination (ID: DCO8X0V)

• Drug Combination Name: Indazole derivative 5 + Plicamycin
• Indication: Invasive ductal carcinoma; Status: Investigative [1]
• Component Drugs:
  Indazole derivative 5 (DMM1I8R): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: BT-549
  Zero Interaction Potency (ZIP) Score: 32.31
  Bliss Independence Score: 31.95
  Loewe Additivity Score: 30.31
  LHighest Single Agent (HSA) Score: 30.26

Molecular Interaction Atlas of This Drug Combination

Indazole derivative 5 Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
ABL T315I mutant (ABL T315I)	TTZJTWA	ABL1_HUMAN	Inhibitor	[5]
Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I)	TTIV39N	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[5]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[2]
Testicular cancer	2C80	Approved	[2]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[3]
Lung cancer	2C25.0	Investigative	[4]
Ovarian cancer	2C73	Investigative	[4]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[7]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[8]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[9]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[9]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[9]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[10]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[10]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[11]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[6]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[12]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[13]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[14]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[6]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[15]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[12]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[16]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[17]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCUMFTB	HL-60(TB)	Investigative	[18]
Adult T acute lymphoblastic leukemia	DCPAJ95	MOLT-4	Investigative	[18]
Anaplastic large cell lymphoma	DCRHUXF	SR	Investigative	[18]
Astrocytoma	DC9FAPK	SNB-19	Investigative	[18]
Chronic myelogenous leukemia	DC6VYXF	K-562	Investigative	[18]
Clear cell renal cell carcinoma	DCF2XJ0	A498	Investigative	[18]
Clear cell renal cell carcinoma	DC3M1GY	786-0	Investigative	[18]
Clear cell renal cell carcinoma	DCB9QWN	TK-10	Investigative	[18]
Clear cell renal cell carcinoma	DCQBU9J	CAKI-1	Investigative	[18]
Glioblastoma	DCY0AHD	SNB-75	Investigative	[18]
Glioma	DCHPYBC	SF-295	Investigative	[18]
Papillary renal cell carcinoma	DCFJYS8	ACHN	Investigative	[18]
Plasma cell myeloma	DCI9O4R	RPMI-8226	Investigative	[18]
Renal cell carcinoma	DCFAM6W	UO-31	Investigative	[18]
Breast adenocarcinoma	DC4KB76	MDA-MB-468	Investigative	[1]
Carcinoma	DCNT3XE	MCF7	Investigative	[1]
Colon adenocarcinoma	DCCAG7O	COLO 205	Investigative	[1]
Colon carcinoma	DC62AHJ	KM12	Investigative	[1]
Invasive ductal carcinoma	DCK3F0N	T-47D	Investigative	[1]
Invasive ductal carcinoma	DCDMYCJ	HS 578T	Investigative	[1]
Adenocarcinoma	DCZG6WP	DU-145	Investigative	[19]
Adenocarcinoma	DCCCLGJ	OVCAR3	Investigative	[19]
Adenocarcinoma	DC4Q8XF	HCC-2998	Investigative	[19]
Adenocarcinoma	DC659YG	HT29	Investigative	[19]
Amelanotic melanoma	DCDCF5O	MDA-MB-435	Investigative	[19]
Amelanotic melanoma	DC8EKGK	M14	Investigative	[19]
Cutaneous melanoma	DCW5TKR	SK-MEL-5	Investigative	[19]
High grade ovarian serous adenocarcinoma	DCHTQRX	OVCAR-4	Investigative	[19]
High grade ovarian serous adenocarcinoma	DCXFSYB	OVCAR-8	Investigative	[19]
High grade ovarian serous adenocarcinoma	DCDLKVS	OVCAR-5	Investigative	[19]
High grade ovarian serous adenocarcinoma	DC1V6R7	NCI\\/ADR-RES	Investigative	[19]
Lung adenocarcinoma	DC4DQKT	MDA-MB-231	Investigative	[19]
Malignant melanoma	DCKJGRV	LOX IMVI	Investigative	[19]
Melanoma	DCU5XVY	MALME-3M	Investigative	[19]
Melanoma	DCEHX1L	UACC-257	Investigative	[19]
Melanoma	DC66JV2	SK-MEL-2	Investigative	[19]
Minimally invasive lung adenocarcinoma	DC3LJKY	NCI-H322M	Investigative	[19]
Mixed endometrioid and clear cell carcinoma	DCUTBHH	IGROV1	Investigative	[19]
Ovarian serous cystadenocarcinoma	DC32BYX	SK-OV-3	Investigative	[19]
Prostate carcinoma	DC1XBEP	PC-3	Investigative	[19]

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• [17] Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin. Biochim Biophys Acta. 2009 Nov-Dec;1789(11-12):681-90. doi: 10.1016/j.bbagrm.2009.08.006. Epub 2009 Aug 19.
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