General Information of Drug Combination (ID: DCOBPZE)

Drug Combination Name
JQ1 Ixazomib
Indication
Disease Entry Status REF
Diffuse intrinsic pontine glioma Investigative [1]
Component Drugs JQ1   DM3XQDH Ixazomib   DM5ZVLB
Small molecular drug N.A.
2D MOL 2D MOL
3D MOL 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: DIPG25
Zero Interaction Potency (ZIP) Score: 12.902
Bliss Independence Score: 11.224
Loewe Additivity Score: 4.696
LHighest Single Agent (HSA) Score: 8.845

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of JQ1
Disease Entry ICD 11 Status REF
Coronavirus Disease 2019 (COVID-19) 1D6Y Investigative [2]
JQ1 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
HUMAN bromodomain-containing protein 2 (BRD2) TTNISW6 BRD2_HUMAN Inhibitor [2]
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Indication(s) of Ixazomib
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Approved [3]

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Uncovering the Role of BRD2 in COVID-19. 2020-03-19
3 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2015