Details of the Drug Combination

General Information of Drug Combination (ID: DCOENWL)

Drug Combination Name

Clascoterone

Indication

Disease Entry	Status	REF
Chronic myelogenous leukemia	Investigative	[1]

High-throughput Screening Result

Testing Cell Line: KBM-7

Zero Interaction Potency (ZIP) Score: 2.51

Bliss Independence Score: 2.51

Loewe Additivity Score: 13.71

LHighest Single Agent (HSA) Score: 13.72

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Clascoterone

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[2]

Clascoterone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Antagonist	[2]
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References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020