Details of the Drug Combination

General Information of Drug Combination (ID: DCOF722)

Drug Combination Name
Edivoxetine Warfarin
Indication
Disease Entry Status REF
Major Depressive Disorder Phase 1 [1]
Component Drugs Edivoxetine   DMFTTMK Warfarin   DMJYCVW
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Edivoxetine
Disease Entry ICD 11 Status REF
Major depressive disorder 6A70.3 Phase 3 [2]
Pediatric attention deficit hyperactivity disorder 6A05 Phase 3 [2]
Indication(s) of Warfarin
Disease Entry ICD 11 Status REF
Atrial fibrillation BC81.3 Approved [3]
Deep vein thrombosis BD71 Approved [4]
Pulmonary hypertension BB01 Approved [4]
Thrombosis DB61-GB90 Application submitted [5]
Intracranial embolism 8B22.1 Investigative [4]
Venous thromboembolism BD72 Investigative [4]
Warfarin Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Vitamin K epoxide reductase complex 1 (VKORC1) TTEUC8H VKOR1_HUMAN Inhibitor [11]
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Warfarin Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
Organic anion transporting polypeptide 1B3 (SLCO1B3) DT9C1TS SO1B3_HUMAN Substrate [12]
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Warfarin Interacts with 8 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [13]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [14]
UDP-glucuronosyltransferase 1A1 (UGT1A1) DEYGVN4 UD11_HUMAN Metabolism [10]
Sulfotransferase 1A1 (SULT1A1) DEYWLRK ST1A1_HUMAN Metabolism [15]
Cytochrome P450 2C18 (CYP2C18) DEZMWRE CP2CI_HUMAN Metabolism [16]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [18]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [14]
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⏷ Show the Full List of 8 DME(s)
Warfarin Interacts with 52 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Expression [19]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Increases Response To Substance [20]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Affects Response To Substance [21]
Cytochrome P450 2C8 (CYP2C8) OTHCWT42 CP2C8_HUMAN Affects Response To Substance [22]
Cytochrome P450 2C18 (CYP2C18) OTY687L9 CP2CI_HUMAN Affects Response To Substance [21]
Solute carrier organic anion transporter family member 1B3 (SLCO1B3) OTOM3BUH SO1B3_HUMAN Affects Response To Substance [23]
Cytochrome P450 4F2 (CYP4F2) OTKILAER CP4F2_HUMAN Increases Response To Substance [24]
Cytochrome P450 2D6 (CYP2D6) OTZJC802 CP2D6_HUMAN Decreases Activity [25]
Nuclear receptor subfamily 1 group I member 2 (NR1I2) OTC5U0N5 NR1I2_HUMAN Decreases Expression [19]
Prothrombin (F2) OTNFSM49 THRB_HUMAN Decreases Expression [26]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Increases Expression [27]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [28]
Albumin (ALB) OTVMM513 ALBU_HUMAN Affects Binding [29]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Degradation [30]
Coagulation factor VII (F7) OTGNJ97M FA7_HUMAN Decreases Expression [26]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Expression [7]
Cadherin-1 (CDH1) OTFJMXPM CADH1_HUMAN Increases Expression [7]
Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) OT0DH40W AL5AP_HUMAN Increases Expression [31]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Expression [7]
Arylsulfatase L (ARSL) OTF1VTCR ARSL_HUMAN Decreases Activity [32]
Growth arrest-specific protein 6 (GAS6) OTPOPUUE GAS6_HUMAN Decreases Carboxylation [7]
Endomucin (EMCN) OTS03CZC MUCEN_HUMAN Decreases Expression [7]
Serine protease 53 (PRSS53) OT3HUUI3 PRS53_HUMAN Affects Response To Substance [33]
Aspartyl/asparaginyl beta-hydroxylase (ASPH) OT3KGDEE ASPH_HUMAN Affects Response To Substance [34]
Ephrin type-A receptor 7 (EPHA7) OT3VC211 EPHA7_HUMAN Affects Response To Substance [35]
Myosin-6 (MYH6) OT3YNCH1 MYH6_HUMAN Affects Response To Substance [36]
Apolipoprotein A-I (APOA1) OT5THARI APOA1_HUMAN Affects Response To Substance [37]
Epoxide hydrolase 1 (EPHX1) OTBKWQER HYEP_HUMAN Increases Response To Substance [38]
Coagulation factor V (F5) OTDMZ3LT FA5_HUMAN Affects Response To Substance [21]
Solute carrier family 15 member 2 (SLC15A2) OTDV7YES S15A2_HUMAN Affects Response To Substance [23]
Vitamin K-dependent gamma-carboxylase (GGCX) OTE0FNAP VKGC_HUMAN Decreases Response To Substance [6]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Affects Response To Substance [39]
Apolipoprotein E (APOE) OTFOWL2H APOE_HUMAN Affects Response To Substance [40]
E3 ubiquitin-protein ligase NEDD4 (NEDD4) OTFPXLXT NEDD4_HUMAN Affects Response To Substance [34]
Vitamin K-dependent protein C (PROC) OTGVH484 PROC_HUMAN Increases Response To Substance [38]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Affects Response To Substance [41]
Prolow-density lipoprotein receptor-related protein 1 (LRP1) OTHTEH4G LRP1_HUMAN Affects Response To Substance [37]
Tyrosine-protein kinase receptor UFO (AXL) OTKA2SUX UFO_HUMAN Increases Response To Substance [7]
Transcription factor GATA-6 (GATA6) OTO2BC0F GATA6_HUMAN Affects Response To Substance [42]
Transcription factor GATA-4 (GATA4) OTQHWAZG GATA4_HUMAN Affects Response To Substance [42]
Fibroblast growth factor 5 (FGF5) OTQXGHBY FGF5_HUMAN Affects Response To Substance [43]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Affects Response To Substance [21]
Calumenin (CALU) OTSYQN71 CALU_HUMAN Affects Response To Substance [44]
Coagulation factor IX (F9) OTT0CX3Q FA9_HUMAN Increases Response To Substance [45]
Heme A synthase COX15 (COX15) OTUIYHIW COX15_HUMAN Affects Response To Substance [43]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Affects Response To Substance [46]
Folylpolyglutamate synthase, mitochondrial (FPGS) OTW3F1ZE FOLC_HUMAN Affects Response To Substance [47]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2) OTW8V2V1 ABCG2_HUMAN Affects Response To Substance [48]
Phospholipase DDHD1 (DDHD1) OTWTHOWK DDHD1_HUMAN Affects Response To Substance [34]
Vitamin K-dependent protein S (PROS1) OTXQWNOI PROS_HUMAN Affects Response To Substance [21]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Affects Response To Substance [49]
Alpha-1-acid glycoprotein 1 (ORM1) OTZKSBRE A1AG1_HUMAN Increases Response To Substance [38]
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⏷ Show the Full List of 52 DOT(s)

References

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