Details of the Drug Combination

General Information of Drug Combination (ID: DCOFG47)

Drug Combination Name
(-)-englerin A cycloheximide
Indication
Disease Entry Status REF
Ewing sarcoma Investigative [1]
Component Drugs (-)-englerin A   DMPQBWY cycloheximide   DMGDA3C
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL is unavailable 3D MOL is unavailable
High-throughput Screening Result Testing Cell Line: TC-71
Zero Interaction Potency (ZIP) Score: 23.877
Bliss Independence Score: 25.821
Loewe Additivity Score: 13.627
LHighest Single Agent (HSA) Score: 15.074

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of (-)-englerin A
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [2]
(-)-englerin A Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Short transient receptor potential channel 5 (TRPC5) TT32NQ1 TRPC5_HUMAN Agonist [4]
Short transient receptor potential channel 4 (TRPC4) TTX0H5W TRPC4_HUMAN Agonist [4]
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Indication(s) of cycloheximide
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [3]
cycloheximide Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [12]
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cycloheximide Interacts with 120 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Expression [13]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [5]
ATP-binding cassette sub-family C member 5 (ABCC5) OT34G4US MRP5_HUMAN Decreases Expression [5]
Transforming acidic coiled-coil-containing protein 1 (TACC1) OTGX20TE TACC1_HUMAN Increases Expression [5]
Trefoil factor 1 (TFF1) OTCYQH4F TFF1_HUMAN Increases Expression [5]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Expression [5]
Amphiregulin (AREG) OTJFOR67 AREG_HUMAN Increases Expression [5]
Cyclin-A2 (CCNA2) OTPHHYZJ CCNA2_HUMAN Decreases Expression [5]
Insulin-like growth factor-binding protein 4 (IGFBP4) OT2HZRBD IBP4_HUMAN Increases Expression [5]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Expression [5]
CCN family member 3 (CCN3) OTOW5YL4 CCN3_HUMAN Increases Expression [5]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Increases Expression [14]
Aryl hydrocarbon receptor (AHR) OTFE4EYE AHR_HUMAN Decreases Expression [14]
Aromatase (CYP19A1) OTZ6XF74 CP19A_HUMAN Decreases Activity [15]
Dynamin-1-like protein (DNM1L) OTXK1Q1G DNM1L_HUMAN Increases Expression [16]
Apoptotic protease-activating factor 1 (APAF1) OTJWIVY0 APAF_HUMAN Decreases Expression [16]
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1) OTWVRR35 GPAA1_HUMAN Increases Expression [16]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Increases Expression [16]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Increases Expression [16]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Expression [16]
Protein kinase C beta type (PRKCB) OTYQ0656 KPCB_HUMAN Decreases Expression [16]
Glia-derived nexin (SERPINE2) OTYF5340 GDN_HUMAN Increases Expression [16]
ETS domain-containing protein Elk-1 (ELK1) OTH9MXD6 ELK1_HUMAN Increases Expression [16]
Pleiotrophin (PTN) OTYC7M2A PTN_HUMAN Increases Expression [16]
CCN family member 2 (CCN2) OTC39NSU CCN2_HUMAN Increases Expression [16]
Kappa-type opioid receptor (OPRK1) OTXCZF4L OPRK_HUMAN Increases Expression [16]
Collagenase 3 (MMP13) OTY8BZIE MMP13_HUMAN Increases Expression [16]
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2) OTMGP4J7 HNRH2_HUMAN Increases Expression [16]
Single-stranded DNA-binding protein, mitochondrial (SSBP1) OTH2PZWH SSBP_HUMAN Increases Expression [16]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Increases Expression [16]
Mitogen-activated protein kinase 7 (MAPK7) OTF7H7L7 MK07_HUMAN Increases Expression [16]
Pappalysin-1 (PAPPA) OTTTG9PG PAPP1_HUMAN Increases Expression [16]
SERTA domain-containing protein 2 (SERTAD2) OTYIG6TP SRTD2_HUMAN Increases Expression [16]
Next to BRCA1 gene 1 protein (NBR1) OTVRL7J9 NBR1_HUMAN Increases Expression [16]
Cytochrome P450 1B1 (CYP1B1) OTYXFLSD CP1B1_HUMAN Increases Expression [16]
5'-3' exonuclease PLD3 (PLD3) OTL07SP2 PLD3_HUMAN Increases Expression [16]
Synaptopodin (SYNPO) OTICDJAB SYNPO_HUMAN Increases Expression [16]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [16]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1) OTGND2YZ SIA8A_HUMAN Increases Expression [16]
Sororin (CDCA5) OTZLCQ5U CDCA5_HUMAN Increases Expression [16]
Retinoic acid receptor responder protein 2 (RARRES2) OT1BJE8K RARR2_HUMAN Increases Expression [16]
Solute carrier family 22 member 4 (SLC22A4) OT4LOVI9 S22A4_HUMAN Increases Expression [16]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Increases Expression [16]
Myotubularin-related protein 7 (MTMR7) OT47NVYM MTMR7_HUMAN Increases Expression [16]
Small ribosomal subunit protein uS7m (MRPS7) OT57AX7G RT07_HUMAN Decreases Expression [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Decreases Expression [17]
Cytochrome P450 2A6 (CYP2A6) OT52TWG3 CP2A6_HUMAN Decreases Expression [18]
Amino acid transporter heavy chain SLC3A2 (SLC3A2) OTBR33M9 4F2_HUMAN Increases Expression [19]
NADPH--cytochrome P450 reductase (POR) OTVIDOCH NCPR_HUMAN Decreases Expression [20]
Tumor protein p53-inducible protein 11 (TP53I11) OTFPDYZU P5I11_HUMAN Decreases Expression [21]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [22]
Transcription regulator protein BACH1 (BACH1) OTY8004K BACH1_HUMAN Decreases Expression [23]
Proepiregulin (EREG) OTRM4NQY EREG_HUMAN Increases Expression [24]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [25]
Autophagy-related protein 13 (ATG13) OTYMHNEJ ATG13_HUMAN Decreases Expression [8]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Decreases Expression [26]
Mitochondrial uncoupling protein 4 (SLC25A27) OTSBOPGD UCP4_HUMAN Increases Expression [27]
Epidermal growth factor receptor (EGFR) OTAPLO1S EGFR_HUMAN Increases Expression [24]
Protein c-Fos (FOS) OTJBUVWS FOS_HUMAN Increases Expression [28]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [29]
Protransforming growth factor alpha (TGFA) OTPD1LL9 TGFA_HUMAN Increases Expression [24]
Transforming growth factor beta-1 proprotein (TGFB1) OTV5XHVH TGFB1_HUMAN Decreases Activity [30]
Estrogen receptor (ESR1) OTKLU61J ESR1_HUMAN Decreases Expression [31]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Expression [32]
Cytochrome P450 2E1 (CYP2E1) OTHQ17JG CP2E1_HUMAN Increases Degradation [33]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Increases Expression [34]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [35]
Transcription factor AP-2-alpha (TFAP2A) OTMYT3NK AP2A_HUMAN Decreases Stability [36]
Beta-2 adrenergic receptor (ADRB2) OTSDOX4Q ADRB2_HUMAN Increases Expression [37]
Rho-related GTP-binding protein RhoC (RHOC) OTOLE1FT RHOC_HUMAN Decreases Expression [38]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [39]
Intestinal-type alkaline phosphatase (ALPI) OTTQ468O PPBI_HUMAN Decreases Activity [40]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [34]
E3 SUMO-protein ligase EGR2 (EGR2) OTAVQ78J EGR2_HUMAN Increases Expression [41]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Decreases Expression [42]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Increases Expression [34]
C-C motif chemokine 5 (CCL5) OTSCA5CK CCL5_HUMAN Increases Expression [34]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Increases Expression [34]
Receptor tyrosine-protein kinase erbB-3 (ERBB3) OTRSST0A ERBB3_HUMAN Decreases Expression [24]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Decreases Expression [32]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Increases Phosphorylation [43]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Increases Phosphorylation [43]
Retinoblastoma-like protein 1 (RBL1) OTDEBFYC RBL1_HUMAN Decreases Expression [44]
Protein PML (PML) OT6SM2GD PML_HUMAN Decreases Degradation [45]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Increases Phosphorylation [46]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Increases Expression [47]
Receptor-type tyrosine-protein kinase FLT3 (FLT3) OTMSRYMK FLT3_HUMAN Decreases Expression [48]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Decreases Expression [49]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [50]
Cyclin-dependent kinase inhibitor 2A (CDKN2A) OTN0ZWAE CDN2A_HUMAN Increases Expression [51]
E3 ubiquitin-protein ligase RNF4 (RNF4) OTCMXQRE RNF4_HUMAN Decreases Expression [52]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) OTTM6KRB ADA17_HUMAN Decreases Stability [53]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Decreases Activity [54]
Urokinase plasminogen activator surface receptor (PLAUR) OTIRKKEQ UPAR_HUMAN Increases Expression [55]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Affects Localization [56]
Recombining binding protein suppressor of hairless (RBPJ) OTD7CUG0 SUH_HUMAN Decreases Expression [57]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Decreases Expression [35]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Increases Expression [58]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Decreases Expression [59]
TAR DNA-binding protein 43 (TARDBP) OTVOSFWW TADBP_HUMAN Decreases Expression [60]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Decreases Expression [61]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Activity [62]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Decreases Expression [63]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Degradation [10]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Decreases Expression [64]
Type II iodothyronine deiodinase (DIO2) OTGPNSLH IOD2_HUMAN Decreases Activity [65]
Sodium/iodide cotransporter (SLC5A5) OTU7E9G7 SC5A5_HUMAN Increases Expression [66]
Transcription termination factor 3, mitochondrial (MTERF3) OTVE8W7X MTEF3_HUMAN Decreases Expression [67]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Decreases Expression [68]
Proheparin-binding EGF-like growth factor (HBEGF) OTLU00JS HBEGF_HUMAN Increases Expression [24]
Endothelial PAS domain-containing protein 1 (EPAS1) OTRE3O8U EPAS1_HUMAN Decreases Expression [69]
Repressor of RNA polymerase III transcription MAF1 homolog (MAF1) OTKB0N8Q MAF1_HUMAN Increases Degradation [70]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Increases Response To Substance [71]
MAP kinase-activated protein kinase 3 (MAPKAPK3) OT7IWJNI MAPK3_HUMAN Affects Response To Substance [11]
D-ribitol-5-phosphate cytidylyltransferase (CRPPA) OTC85K8Q ISPD_HUMAN Affects Response To Substance [11]
Rab9 effector protein with kelch motifs (RABEPK) OTCZSREH RABEK_HUMAN Affects Response To Substance [11]
Kremen protein 1 (KREMEN1) OTGJFSAC KREM1_HUMAN Affects Response To Substance [11]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Response To Substance [72]
Unconventional myosin-Id (MYO1D) OTP2RGPN MYO1D_HUMAN Affects Response To Substance [11]
Cation channel sperm-associated protein 4 (CATSPER4) OTXJ4E8J CTSR4_HUMAN Affects Response To Substance [11]
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⏷ Show the Full List of 120 DOT(s)

References

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