Details of the Drug Combination

General Information of Drug Combination (ID: DCOUXMY)

Drug Combination Name
Arfolitixorin Bortezomib
Indication
Disease Entry Status REF
Glioma Investigative [1]
Component Drugs Arfolitixorin   DMIXMYK Bortezomib   DMNO38U
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SF-295
Zero Interaction Potency (ZIP) Score: 5.52
Bliss Independence Score: 7.11
Loewe Additivity Score: 9.91
LHighest Single Agent (HSA) Score: 9.89

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Arfolitixorin
Disease Entry ICD 11 Status REF
Colorectal cancer 2B91.Z Phase 3 [2]
Indication(s) of Bortezomib
Disease Entry ICD 11 Status REF
Leukemia N.A. Approved [3]
Lung cancer 2C25.0 Approved [3]
Lymphoproliferative syndrome N.A. Approved [3]
MALT lymphoma N.A. Approved [3]
Mantle cell lymphoma 2A85.5 Approved [4]
Minimally invasive lung adenocarcinoma N.A. Approved [3]
Multiple myeloma 2A83 Approved [5]
Nodal marginal zone lymphoma 2A85.0 Approved [3]
Plasma cell myeloma 2A83.1 Approved [3]
Recurrent adult burkitt lymphoma 2A85.6 Approved [3]
Non-hodgkin lymphoma 2B33.5 Phase 3 [5]
B-cell neoplasm N.A. Investigative [3]
Colon cancer 2B90.Z Investigative [3]
Gastric cancer 2B72 Investigative [3]
Bortezomib Interacts with 3 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Cationic trypsinogen (PRSS1) TT2WR1T TRY1_HUMAN Inhibitor [12]
Kallikrein-related peptidase (KLK) TT5L2VC NOUNIPROTAC Inhibitor [12]
Proteasome (PS) TTU7ZMG NOUNIPROTAC Modulator [13]
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Bortezomib Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [14]
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Bortezomib Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [15]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Metabolism [16]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Metabolism [17]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Metabolism [18]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Metabolism [17]
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Bortezomib Interacts with 686 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Decreases Expression [19]
Extended synaptotagmin-2 (ESYT2) OTWCXTX3 ESYT2_HUMAN Decreases Expression [6]
Alternative prion protein (PRNP) OTE85L1Q APRIO_HUMAN Increases Expression [6]
Serine/threonine-protein kinase Sgk1 (SGK1) OT301T1U SGK1_HUMAN Increases Expression [6]
Cytosolic acyl coenzyme A thioester hydrolase (ACOT7) OT7C68YV BACH_HUMAN Decreases Expression [6]
GTP-binding protein 1 (GTPBP1) OTA9KV6C GTPB1_HUMAN Decreases Expression [6]
Galectin-8 (LGALS8) OT71LJ8T LEG8_HUMAN Increases Expression [6]
26S proteasome non-ATPase regulatory subunit 12 (PSMD12) OTWICA51 PSD12_HUMAN Increases Expression [6]
Leukocyte-specific transcript 1 protein (LST1) OTUVG424 LST1_HUMAN Decreases Expression [6]
Agrin (AGRN) OTWJENAZ AGRIN_HUMAN Decreases Expression [6]
Krev interaction trapped protein 1 (KRIT1) OT58AP1I KRIT1_HUMAN Increases Expression [6]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG) OTUX45ZF MFNG_HUMAN Decreases Expression [6]
Pirin (PIR) OT8ALXHU PIR_HUMAN Increases Expression [6]
Pyridoxal kinase (PDXK) OT40AJ5J PDXK_HUMAN Increases Expression [6]
Stearoyl-CoA desaturase (SCD) OTB1073G SCD_HUMAN Decreases Expression [6]
Suppressor of cytokine signaling 3 (SOCS3) OTY183WJ SOCS3_HUMAN Increases Expression [6]
TRAF-type zinc finger domain-containing protein 1 (TRAFD1) OT7AU2R3 TRAD1_HUMAN Increases Expression [6]
Cytoplasmic dynein 1 intermediate chain 1 (DYNC1I1) OTFX1KCG DC1I1_HUMAN Increases Expression [6]
Chromodomain-helicase-DNA-binding protein 2 (CHD2) OTRKL6YC CHD2_HUMAN Increases Expression [6]
Golgi SNAP receptor complex member 2 (GOSR2) OTYHIYN2 GOSR2_HUMAN Increases Expression [6]
Disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) OTOKUXUH ADA10_HUMAN Decreases Expression [6]
Apolipoprotein L1 (APOL1) OT8QBVTY APOL1_HUMAN Increases Expression [6]
Interferon-inducible protein AIM2 (AIM2) OT86QUI8 AIM2_HUMAN Increases Expression [6]
Myosin regulatory light chain 12B (MYL12B) OTXMLQOT ML12B_HUMAN Increases Expression [6]
Centrosomal protein of 290 kDa (CEP290) OTVN52VH CE290_HUMAN Increases Expression [6]
Small ribosomal subunit protein uS12m (MRPS12) OTGY4GIX RT12_HUMAN Decreases Expression [6]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) OT1Z1ZXE OGT1_HUMAN Decreases Expression [6]
V-type proton ATPase subunit e 1 (ATP6V0E1) OTZZIUYY VA0E1_HUMAN Increases Expression [6]
ATP-binding cassette sub-family C member 4 (ABCC4) OTO27PAL MRP4_HUMAN Decreases Expression [6]
Transcription factor MafG (MAFG) OTBQFUZH MAFG_HUMAN Increases Expression [6]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2) OT6Y1QZN IRAK2_HUMAN Increases Expression [6]
PHD finger protein 1 (PHF1) OTW2PSIR PHF1_HUMAN Increases Expression [6]
Synaptogyrin-2 (SYNGR2) OTJX84RI SNG2_HUMAN Decreases Expression [6]
Cytohesin-interacting protein (CYTIP) OTRJ3ZC5 CYTIP_HUMAN Increases Expression [6]
Growth arrest-specific protein 7 (GAS7) OT0M5TNY GAS7_HUMAN Decreases Expression [6]
F-box-like/WD repeat-containing protein TBL1X (TBL1X) OTXQ51E0 TBL1X_HUMAN Increases Expression [6]
Glycosaminoglycan xylosylkinase (FAM20B) OTOA0UYT XYLK_HUMAN Decreases Expression [6]
Suppressor of cytokine signaling 5 (SOCS5) OTN1ABYR SOCS5_HUMAN Increases Expression [6]
Protein tyrosine phosphatase type IVA 3 (PTP4A3) OTXMMWUN TP4A3_HUMAN Decreases Expression [6]
Deformed epidermal autoregulatory factor 1 homolog (DEAF1) OTCLX3ZW DEAF1_HUMAN Decreases Expression [6]
Calpain-15 (CAPN15) OT0WE161 CAN15_HUMAN Decreases Expression [6]
Carbonyl reductase 3 (CBR3) OT9G6SF0 CBR3_HUMAN Increases Expression [6]
Triple functional domain protein (TRIO) OT71X1AK TRIO_HUMAN Decreases Expression [6]
Cystatin-F (CST7) OTQWZUVQ CYTF_HUMAN Increases Expression [6]
ATP-dependent DNA helicase Q4 (RECQL4) OT59LSW7 RECQ4_HUMAN Increases Expression [6]
Erlin-2 (ERLIN2) OT551BVG ERLN2_HUMAN Decreases Expression [6]
Pre-mRNA-processing factor 6 (PRPF6) OT3U0ABN PRP6_HUMAN Decreases Expression [6]
Lysine-specific demethylase 4B (KDM4B) OT5P1UPY KDM4B_HUMAN Decreases Expression [6]
Methyl-CpG-binding domain protein 4 (MBD4) OTWR9YXE MBD4_HUMAN Increases Expression [6]
Arginyl-tRNA--protein transferase 1 (ATE1) OT3QNM39 ATE1_HUMAN Increases Expression [6]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Decreases Expression [6]
NAD kinase (NADK) OTYN9GX0 NADK_HUMAN Decreases Expression [6]
AP-2 complex subunit alpha-1 (AP2A1) OTEFZB21 AP2A1_HUMAN Decreases Expression [6]
Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) OTBMJUOC M4K4_HUMAN Increases Expression [6]
Acyl-CoA 6-desaturase (FADS2) OTUX531P FADS2_HUMAN Decreases Expression [6]
Phosphatidylserine lipase ABHD16A (ABHD16A) OTDS9K1Z ABHGA_HUMAN Increases Expression [6]
G patch domain and ankyrin repeat-containing protein 1 (GPANK1) OT1TN2KT GPAN1_HUMAN Increases Expression [6]
Putative lipid scramblase CLPTM1 (CLPTM1) OT14QP7N CLPT1_HUMAN Decreases Expression [6]
Glutathione reductase, mitochondrial (GSR) OTM2TUYM GSHR_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DR alpha chain (HLA-DRA) OT7KZMP2 DRA_HUMAN Decreases Expression [6]
Myelin basic protein (MBP) OTFZCEDB MBP_HUMAN Decreases Expression [6]
Thy-1 membrane glycoprotein (THY1) OTVONVTB THY1_HUMAN Decreases Expression [6]
HLA class II histocompatibility antigen, DP beta 1 chain (HLA-DPB1) OTW8JHU2 DPB1_HUMAN Decreases Expression [6]
T-cell surface glycoprotein CD5 (CD5) OTC5JEG5 CD5_HUMAN Decreases Expression [6]
Alpha-galactosidase A (GLA) OTBSR6DT AGAL_HUMAN Increases Expression [6]
HLA class II histocompatibility antigen, DO alpha chain (HLA-DOA) OTZE5Q7R DOA_HUMAN Decreases Expression [6]
Cathepsin D (CTSD) OTQZ36F3 CATD_HUMAN Increases Expression [6]
Trypsin-2 (PRSS2) OTOMVUWL TRY2_HUMAN Decreases Expression [6]
Prosaposin (PSAP) OTUOEKY7 SAP_HUMAN Increases Expression [6]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3) OT89UWAR GNAI3_HUMAN Increases Expression [6]
Steryl-sulfatase (STS) OTXTJQPC STS_HUMAN Decreases Expression [6]
Monoacylglycerol lipase ABHD2 (ABHD2) OTCRUOCS ABHD2_HUMAN Increases Expression [6]
Gamma-enolase (ENO2) OTRODL0T ENOG_HUMAN Increases Expression [6]
Tropomyosin alpha-1 chain (TPM1) OTD73X6R TPM1_HUMAN Increases Expression [6]
Cancer/testis antigen family 45 member A6 (CT45A5) OTIFETOM CT456_HUMAN Increases Expression [6]
Schwannomin-interacting protein 1 (SCHIP1) OTF3FR4A SCHI1_HUMAN Decreases Expression [6]
Granzyme B (GZMB) OTPPVIRS GRAB_HUMAN Increases Expression [6]
Clusterin (CLU) OTQGG0JM CLUS_HUMAN Increases Expression [6]
Endoplasmic reticulum chaperone BiP (HSPA5) OTFUIRAO BIP_HUMAN Increases Expression [6]
Phenylethanolamine N-methyltransferase (PNMT) OTGLCPE8 PNMT_HUMAN Decreases Expression [6]
Solute carrier family 2, facilitated glucose transporter member 3 (SLC2A3) OT2HZK5M GTR3_HUMAN Increases Expression [6]
Ras-related protein Ral-A (RALA) OT734R7X RALA_HUMAN Increases Expression [6]
Breakpoint cluster region protein (BCR) OTCN76C1 BCR_HUMAN Decreases Expression [6]
Glucose-6-phosphate 1-dehydrogenase (G6PD) OT300SMK G6PD_HUMAN Decreases Expression [6]
Steroid hormone receptor ERR1 (ESRRA) OTTDTUSP ERR1_HUMAN Decreases Expression [6]
B-cell antigen receptor complex-associated protein alpha chain (CD79A) OTOJC8DV CD79A_HUMAN Decreases Expression [6]
Granzyme A (GZMA) OT43R33L GRAA_HUMAN Decreases Expression [6]
Cytochrome b-245 light chain (CYBA) OT16N9ZO CY24A_HUMAN Decreases Expression [6]
Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) OTM8EG6H AT1A3_HUMAN Decreases Expression [6]
Perforin-1 (PRF1) OTFVXD7H PERF_HUMAN Decreases Expression [6]
Insulin-degrading enzyme (IDE) OT5GQTJ5 IDE_HUMAN Increases Expression [6]
Ras-related C3 botulinum toxin substrate 2 (RAC2) OTAOHFNH RAC2_HUMAN Decreases Expression [6]
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (GSPT1) OT18H1B0 ERF3A_HUMAN Decreases Expression [6]
Folate receptor alpha (FOLR1) OT0QZ0H6 FOLR1_HUMAN Decreases Expression [6]
Cyclic AMP-dependent transcription factor ATF-2 (ATF2) OTNIZPEA ATF2_HUMAN Increases Expression [6]
NAD(P)H dehydrogenase 1 (NQO1) OTZGGIVK NQO1_HUMAN Increases Expression [6]
Immunoglobulin lambda-like polypeptide 1 (IGLL1) OTRTNVOG IGLL1_HUMAN Decreases Expression [6]
Mucin-1 (MUC1) OTHQI7IY MUC1_HUMAN Decreases Expression [6]
Ribosyldihydronicotinamide dehydrogenase (NQO2) OTGDAJRZ NQO2_HUMAN Increases Expression [6]
Leukosialin (SPN) OTFW338K LEUK_HUMAN Decreases Expression [6]
Transcription factor JunD (JUND) OTNKACJD JUND_HUMAN Decreases Expression [6]
Integrin beta-6 (ITGB6) OTI3DJ7U ITB6_HUMAN Increases Expression [6]
Ras-related protein Rab-5A (RAB5A) OTFR2KM4 RAB5A_HUMAN Decreases Expression [6]
Integrin alpha-L (ITGAL) OTCUQAIS ITAL_HUMAN Decreases Expression [6]
B-cell lymphoma 3 protein (BCL3) OT1M5B95 BCL3_HUMAN Decreases Expression [6]
5'-nucleotidase (NT5E) OT7J5LT6 5NTD_HUMAN Decreases Expression [6]
Ephrin type-A receptor 1 (EPHA1) OTGJMRZ0 EPHA1_HUMAN Decreases Expression [6]
CD9 antigen (CD9) OT2184XU CD9_HUMAN Increases Expression [6]
Integrin alpha-6 (ITGA6) OT3FA39C ITA6_HUMAN Decreases Expression [6]
Ribosomal protein S6 kinase beta-1 (RPS6KB1) OTAELNGX KS6B1_HUMAN Increases Expression [6]
Tyrosine-protein kinase JAK1 (JAK1) OT0X3D17 JAK1_HUMAN Decreases Expression [6]
ER lumen protein-retaining receptor 1 (KDELR1) OT8YBS5G ERD21_HUMAN Decreases Expression [6]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A) OTDRV63V GA45A_HUMAN Increases Expression [6]
Polypyrimidine tract-binding protein 1 (PTBP1) OT2OBJUK PTBP1_HUMAN Decreases Expression [6]
NKG2-D type II integral membrane protein (KLRK1) OTQWXK71 NKG2D_HUMAN Decreases Expression [6]
CD82 antigen (CD82) OTH8MC64 CD82_HUMAN Decreases Expression [6]
HLA class II histocompatibility antigen, DM beta chain (HLA-DMB) OT17HGXJ DMB_HUMAN Decreases Expression [6]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38) OTG0TTX7 CD38_HUMAN Decreases Expression [6]
Ephrin type-B receptor 2 (EPHB2) OT8VZ6C5 EPHB2_HUMAN Decreases Expression [6]
Flavin reductase (BLVRB) OTHCFN2C BLVRB_HUMAN Increases Expression [6]
G1/S-specific cyclin-D2 (CCND2) OTDULQF9 CCND2_HUMAN Decreases Expression [6]
Homeobox protein Hox-A11 (HOXA11) OT42C4HF HXA11_HUMAN Decreases Expression [6]
14-3-3 protein sigma (SFN) OTLJCZ1U 1433S_HUMAN Increases Expression [6]
Stress-induced-phosphoprotein 1 (STIP1) OT7TXLOX STIP1_HUMAN Decreases Expression [6]
Guanylate-binding protein 2 (GBP2) OTVU4G07 GBP2_HUMAN Increases Expression [6]
Multidrug resistance-associated protein 1 (ABCC1) OTGUN89S MRP1_HUMAN Decreases Expression [6]
Protein phosphatase 1A (PPM1A) OT1U770U PPM1A_HUMAN Increases Expression [6]
Transcription factor 7 (TCF7) OT1ID822 TCF7_HUMAN Decreases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) OTUE7Z91 MP2K2_HUMAN Decreases Expression [6]
Transgelin-2 (TAGLN2) OTUXZGDQ TAGL2_HUMAN Decreases Expression [6]
Pre-B-cell leukemia transcription factor 3 (PBX3) OT8WMVM4 PBX3_HUMAN Decreases Expression [6]
Interleukin-15 (IL15) OTQSYWQS IL15_HUMAN Increases Expression [6]
Trifunctional enzyme subunit alpha, mitochondrial (HADHA) OTO557N2 ECHA_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 2 subunit 3 (EIF2S3) OTARRES9 IF2G_HUMAN Decreases Expression [6]
B-cell lymphoma 6 protein (BCL6) OTQAWWO1 BCL6_HUMAN Increases Expression [6]
Lysine-specific demethylase 5C (KDM5C) OTZ6E0HY KDM5C_HUMAN Decreases Expression [6]
Eukaryotic translation initiation factor 1 (EIF1) OTB4GZ0V EIF1_HUMAN Increases Expression [6]
5-hydroxytryptamine receptor 2B (HTR2B) OTM1AD9J 5HT2B_HUMAN Decreases Expression [6]
Lamina-associated polypeptide 2, isoform alpha (TMPO) OTL68EL4 LAP2A_HUMAN Decreases Expression [6]
ETS translocation variant 4 (ETV4) OT8C98UZ ETV4_HUMAN Decreases Expression [6]
Killer cell immunoglobulin-like receptor 2DS4 (KIR2DS4) OT00N6UJ KI2S4_HUMAN Decreases Expression [6]
26S proteasome regulatory subunit 6B (PSMC4) OTS3XN41 PRS6B_HUMAN Increases Expression [6]
Lys-63-specific deubiquitinase BRCC36 (BRCC3) OTK0ZN7Y BRCC3_HUMAN Decreases Expression [6]
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) OT729S0T LIMS1_HUMAN Increases Expression [6]
NADP-dependent malic enzyme (ME1) OTSVEUQE MAOX_HUMAN Increases Expression [6]
MAP kinase-activated protein kinase 2 (MAPKAPK2) OT460SBO MAPK2_HUMAN Decreases Expression [6]
Large ribosomal subunit protein bL19m (MRPL19) OTRBKF6R RM19_HUMAN Increases Expression [6]
Beta-arrestin-1 (ARRB1) OT2NJS37 ARRB1_HUMAN Decreases Expression [6]
Ubiquitin-conjugating enzyme E2 R1 (CDC34) OTNBK390 UB2R1_HUMAN Increases Expression [6]
Choline-phosphate cytidylyltransferase A (PCYT1A) OTMH0YLN PCY1A_HUMAN Increases Expression [6]
Protein phosphatase 1F (PPM1F) OTU0MVR7 PPM1F_HUMAN Increases Expression [6]
Protein numb homolog (NUMB) OTMB586Q NUMB_HUMAN Increases Expression [6]
Presenilin-1 (PSEN1) OTKL39RT PSN1_HUMAN Decreases Expression [6]
Cytosolic purine 5'-nucleotidase (NT5C2) OTJMF66Z 5NTC_HUMAN Increases Expression [6]
DNA ligase 4 (LIG4) OT40DNXU DNLI4_HUMAN Increases Expression [6]
Dynamin-2 (DNM2) OTUYU2U3 DYN2_HUMAN Decreases Expression [6]
Poly(A) polymerase alpha (PAPOLA) OTPHD65D PAPOA_HUMAN Decreases Expression [6]
Tyrosine-protein kinase Blk (BLK) OT1EB8MT BLK_HUMAN Decreases Expression [6]
Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) OTF3TBTK SSDH_HUMAN Decreases Expression [6]
26S proteasome non-ATPase regulatory subunit 7 (PSMD7) OT7PZZ4K PSMD7_HUMAN Increases Expression [6]
N-sulphoglucosamine sulphohydrolase (SGSH) OTLSSEOS SPHM_HUMAN Increases Expression [6]
AF4/FMR2 family member 1 (AFF1) OTT2C78E AFF1_HUMAN Increases Expression [6]
Importin subunit alpha-1 (KPNA2) OTU7FOE6 IMA1_HUMAN Increases Expression [6]
Diacylglycerol kinase epsilon (DGKE) OTWS86AS DGKE_HUMAN Decreases Expression [6]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6) OTK13JKC MP2K6_HUMAN Decreases Expression [6]
Rho GDP-dissociation inhibitor 1 (ARHGDIA) OTEXWJDO GDIR1_HUMAN Decreases Expression [6]
Cysteine-rich protein 2 (CRIP2) OTVVJSYX CRIP2_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 5 (PPP5C) OTC3HT6Y PPP5_HUMAN Decreases Expression [6]
Delta-1-pyrroline-5-carboxylate synthase (ALDH18A1) OT6W40XU P5CS_HUMAN Decreases Expression [6]
Proteinase-activated receptor 2 (F2RL1) OTMRMJ8N PAR2_HUMAN Decreases Expression [6]
Myc-associated zinc finger protein (MAZ) OTEHKN1M MAZ_HUMAN Decreases Expression [6]
ADP-ribosylation factor-like protein 4C (ARL4C) OTQ3QNNU ARL4C_HUMAN Decreases Expression [6]
Small integral membrane protein 11 (SMIM11) OTZPLVUC SIM11_HUMAN Decreases Expression [6]
Triosephosphate isomerase (TPI1) OT14KP4B TPIS_HUMAN Increases Expression [6]
Cell division control protein 42 homolog (CDC42) OT5QBC5M CDC42_HUMAN Decreases Expression [6]
C-X-C chemokine receptor type 4 (CXCR4) OTUFSBX2 CXCR4_HUMAN Decreases Expression [6]
Large ribosomal subunit protein uL24 (RPL26) OTFNRC27 RL26_HUMAN Increases Expression [6]
cAMP-dependent protein kinase inhibitor alpha (PKIA) OT8M5GVO IPKA_HUMAN Increases Expression [6]
AP-1 complex subunit sigma-1A (AP1S1) OTQ2H8DN AP1S1_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS17 (RPS11) OTILZE44 RS11_HUMAN Increases Expression [6]
ADP-ribosylation factor 6 (ARF6) OTVV7KJO ARF6_HUMAN Increases Expression [6]
Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) OT6285L4 FKB1A_HUMAN Decreases Expression [6]
Calcineurin subunit B type 1 (PPP3R1) OTGQNFJQ CANB1_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform (PPP2R2A) OT9297OG 2ABA_HUMAN Increases Expression [6]
Small ubiquitin-related modifier 1 (SUMO1) OTJFD4P5 SUMO1_HUMAN Increases Expression [6]
Eukaryotic translation initiation factor 5A-1 (EIF5A) OTQ8DJX5 IF5A1_HUMAN Decreases Expression [6]
DNA-dependent protein kinase catalytic subunit (PRKDC) OTJVS4EG PRKDC_HUMAN Decreases Expression [6]
Small ribosomal subunit protein uS5m (MRPS5) OTZZR208 RT05_HUMAN Decreases Expression [6]
Spectrin beta chain, non-erythrocytic 1 (SPTBN1) OTOVM4D4 SPTB2_HUMAN Increases Expression [6]
Large neutral amino acids transporter small subunit 1 (SLC7A5) OT2WPVXD LAT1_HUMAN Decreases Expression [6]
2-oxoglutarate dehydrogenase complex component E1 (OGDH) OTHGTQWF ODO1_HUMAN Decreases Expression [6]
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase , mitochondrial (ALDH6A1) OT8LCZCT MMSA_HUMAN Decreases Expression [6]
Mitochondrial 2-oxoglutarate/malate carrier protein (SLC25A11) OT7EVFBK M2OM_HUMAN Decreases Expression [6]
Glutathione S-transferase Mu 4 (GSTM4) OTOTF8DU GSTM4_HUMAN Decreases Expression [6]
cAMP-responsive element modulator (CREM) OTJIJ5AL CREM_HUMAN Increases Expression [6]
Centromere protein C (CENPC) OTVJ6VE9 CENPC_HUMAN Increases Expression [6]
Transcription factor p65 (RELA) OTUJP9CN TF65_HUMAN Decreases Expression [6]
Neurogenic locus notch homolog protein 2 (NOTCH2) OTQ3Y9PA NOTC2_HUMAN Decreases Expression [6]
CTD small phosphatase-like protein 2 (CTDSPL2) OTPF8W4P CTSL2_HUMAN Decreases Expression [6]
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) OTFH9M73 PTN11_HUMAN Decreases Expression [6]
Early activation antigen CD69 (CD69) OTGJHSVP CD69_HUMAN Increases Expression [6]
Serine/arginine-rich splicing factor 1 (SRSF1) OTF61HOV SRSF1_HUMAN Decreases Expression [6]
Rho GTPase-activating protein 1 (ARHGAP1) OT0H2ZBZ RHG01_HUMAN Decreases Expression [6]
FACT complex subunit SSRP1 (SSRP1) OT5TYJK9 SSRP1_HUMAN Decreases Expression [6]
Sodium/bile acid cotransporter 7 (SLC10A7) OTYLAWNV NTCP7_HUMAN Increases Expression [6]
Apolipoprotein B receptor (APOBR) OT9EUZX3 APOBR_HUMAN Decreases Expression [6]
Nuclear factor 1 A-type (NFIA) OTDHQ9CG NFIA_HUMAN Decreases Expression [6]
Interferon-related developmental regulator 2 (IFRD2) OT2URF18 IFRD2_HUMAN Decreases Expression [6]
Protein AF1q (MLLT11) OTG5RVHC AF1Q_HUMAN Increases Expression [6]
PR domain zinc finger protein 2 (PRDM2) OT8L7CGX PRDM2_HUMAN Decreases Expression [6]
Dual specificity protein phosphatase 4 (DUSP4) OT6WAO12 DUS4_HUMAN Decreases Expression [6]
Oxysterols receptor LXR-alpha (NR1H3) OT54YZ9I NR1H3_HUMAN Decreases Expression [6]
Chromobox protein homolog 3 (CBX3) OTOP9RLD CBX3_HUMAN Increases Expression [6]
Phosducin-like protein (PDCL) OTDNHIXG PHLP_HUMAN Increases Expression [6]
DNA-binding protein Ikaros (IKZF1) OTCW1FKL IKZF1_HUMAN Decreases Expression [6]
Protein OS-9 (OS9) OTB5B2TY OS9_HUMAN Increases Expression [6]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Decreases Expression [6]
Sequestosome-1 (SQSTM1) OTGY5D5J SQSTM_HUMAN Increases Expression [6]
Transformer-2 protein homolog alpha (TRA2A) OT5NHOO3 TRA2A_HUMAN Decreases Expression [6]
Rap guanine nucleotide exchange factor 1 (RAPGEF1) OTZ0TBN1 RPGF1_HUMAN Decreases Expression [6]
High affinity 3',5'-cyclic-AMP phosphodiesterase 7A (PDE7A) OTVDV4IT PDE7A_HUMAN Decreases Expression [6]
Nuclear transcription factor Y subunit gamma (NFYC) OTZVVEV7 NFYC_HUMAN Decreases Expression [6]
Transcription factor Dp-1 (TFDP1) OT6RZ7VT TFDP1_HUMAN Decreases Expression [6]
Fas-activated serine/threonine kinase (FASTK) OTTHFZMP FASTK_HUMAN Decreases Expression [6]
Mediator of DNA damage checkpoint protein 1 (MDC1) OTEUQH4J MDC1_HUMAN Decreases Expression [6]
Structural maintenance of chromosomes protein 1A (SMC1A) OT9ZMRK9 SMC1A_HUMAN Decreases Expression [6]
Neutral alpha-glucosidase AB (GANAB) OTYLXY4M GANAB_HUMAN Decreases Expression [6]
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) OT43TTX0 2A5D_HUMAN Decreases Expression [6]
Kinesin-like protein KIF22 (KIF22) OTY6X6BL KIF22_HUMAN Decreases Expression [6]
Killer cell immunoglobulin-like receptor 3DS1 (KIR3DS1) OTJWIO4T KI3S1_HUMAN Decreases Expression [6]
Killer cell immunoglobulin-like receptor 2DS3 (KIR2DS3) OT3PSLDL KI2S3_HUMAN Decreases Expression [6]
DAZ-associated protein 2 (DAZAP2) OTNURO9F DAZP2_HUMAN Decreases Expression [6]
Neutrophil cytosol factor 4 (NCF4) OTX007YL NCF4_HUMAN Decreases Expression [6]
kinase isozyme 2, mitochondrial (PDK2) OTM436F9 PDK2_HUMAN Decreases Expression [6]
Leucine-rich repeat-containing protein 41 (LRRC41) OT4YSBV5 LRC41_HUMAN Decreases Expression [6]
Ras suppressor protein 1 (RSU1) OTO5GHT1 RSU1_HUMAN Increases Expression [6]
Scaffold attachment factor B1 (SAFB) OTGRV2LW SAFB1_HUMAN Decreases Expression [6]
NF-kappa-B inhibitor beta (NFKBIB) OTY1ZJXH IKBB_HUMAN Increases Expression [6]
NGFI-A-binding protein 2 (NAB2) OTG4BDF3 NAB2_HUMAN Decreases Expression [6]
Neuronal pentraxin-1 (NPTX1) OTKVHCV0 NPTX1_HUMAN Decreases Expression [6]
Coiled-coil domain-containing protein 6 (CCDC6) OTXRQDYG CCDC6_HUMAN Decreases Expression [6]
Drebrin (DBN1) OTZVKG8A DREB_HUMAN Increases Expression [6]
Solute carrier family 35 member G1 (SLC35G1) OTKZUA8O S35G1_HUMAN Decreases Expression [6]
Protein mono-ADP-ribosyltransferase PARP6 (PARP6) OTWSXW4O PARP6_HUMAN Decreases Expression [6]
Leucine-rich repeat flightless-interacting protein 1 (LRRFIP1) OTN7XAUD LRRF1_HUMAN Increases Expression [6]
Polycomb group RING finger protein 3 (PCGF3) OTY7TPPZ PCGF3_HUMAN Increases Expression [6]
NAD kinase 2, mitochondrial (NADK2) OT1I8GDE NAKD2_HUMAN Increases Expression [6]
B-cell CLL/lymphoma 7 protein family member A (BCL7A) OTYFUJTP BCL7A_HUMAN Decreases Expression [6]
Glycerol-3-phosphate acyltransferase 3 (GPAT3) OTJUGPK0 GPAT3_HUMAN Increases Expression [6]
Acylglycerol kinase, mitochondrial (AGK) OTJGWBYT AGK_HUMAN Decreases Expression [6]
Vesicle transport protein SFT2C (SFT2D3) OT0IEAAR SFT2C_HUMAN Decreases Expression [6]
Transmembrane protein 41B (TMEM41B) OTW0B0KS TM41B_HUMAN Increases Expression [6]
Torsin-1A-interacting protein 1 (TOR1AIP1) OTTG8MAK TOIP1_HUMAN Decreases Expression [6]
Tetratricopeptide repeat protein 39A (TTC39A) OT80PQWX TT39A_HUMAN Increases Expression [6]
Protein furry homolog (FRY) OT74IAG2 FRY_HUMAN Increases Expression [6]
Probable E3 ubiquitin-protein ligase HECTD2 (HECTD2) OTDIBGQV HECD2_HUMAN Increases Expression [6]
G-protein coupled receptor 157 (GPR157) OTE7K9D7 GP157_HUMAN Decreases Expression [6]
Obscurin (OBSCN) OTT14OVX OBSCN_HUMAN Decreases Expression [6]
G kinase-anchoring protein 1 (GKAP1) OTHZRJ56 GKAP1_HUMAN Increases Expression [6]
Protein TASOR 2 (TASOR2) OTN4VE8H TASO2_HUMAN Decreases Expression [6]
Sushi domain-containing protein 4 (SUSD4) OTWCJTT3 SUSD4_HUMAN Decreases Expression [6]
Proteasome adapter and scaffold protein ECM29 (ECPAS) OT1C0KOI ECM29_HUMAN Increases Expression [6]
DENN domain-containing protein 4C (DENND4C) OT8SYN47 DEN4C_HUMAN Increases Expression [6]
Pecanex-like protein 4 (PCNX4) OTV474RQ PCX4_HUMAN Increases Expression [6]
Protein SPT2 homolog (SPTY2D1) OT1RY99Z SPT2_HUMAN Increases Expression [6]
CWF19-like protein 1 (CWF19L1) OTAMYTOW C19L1_HUMAN Decreases Expression [6]
U11/U12 small nuclear ribonucleoprotein 48 kDa protein (SNRNP48) OTSR6DEJ SNR48_HUMAN Increases Expression [6]
Tyrosine-protein kinase STYK1 (STYK1) OT61CSU7 STYK1_HUMAN Increases Expression [6]
SPRY domain-containing SOCS box protein 3 (SPSB3) OTHGEE2K SPSB3_HUMAN Increases Expression [6]
E3 ubiquitin-protein ligase TRIM65 (TRIM65) OTSQTK3A TRI65_HUMAN Decreases Expression [6]
Leucine-rich repeat and fibronectin type-III domain-containing protein 4 (LRFN4) OT7RWBKE LRFN4_HUMAN Decreases Expression [6]
Type-1 angiotensin II receptor-associated protein (AGTRAP) OT02N7LD ATRAP_HUMAN Decreases Expression [6]
Transmembrane protein 92 (TMEM92) OTTKJ2C0 TMM92_HUMAN Decreases Expression [6]
MICOS complex subunit MIC27 (APOOL) OTC1WT8O MIC27_HUMAN Increases Expression [6]
DnaJ homolog subfamily C member 14 (DNAJC14) OT7DPIVN DJC14_HUMAN Decreases Expression [6]
TBC1 domain family member 9 (TBC1D9) OTSSCTB5 TBCD9_HUMAN Increases Expression [6]
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) OTMQXW7S RAPH1_HUMAN Increases Expression [6]
Serine/threonine-protein kinase MARK2 (MARK2) OTJWGLUZ MARK2_HUMAN Decreases Expression [6]
Ribonucleoside-diphosphate reductase subunit M2 B (RRM2B) OTE8GBUR RIR2B_HUMAN Increases Expression [6]
Probable C-mannosyltransferase DPY19L4 (DPY19L4) OTQ89TXA D19L4_HUMAN Increases Expression [6]
Coiled-coil domain-containing protein 186 (CCDC186) OTONSQAD CC186_HUMAN Increases Expression [6]
C-myc promoter-binding protein (DENND4A) OT8FFZ29 MYCPP_HUMAN Increases Expression [6]
Cytochrome P450 2U1 (CYP2U1) OT6RXLXS CP2U1_HUMAN Increases Expression [6]
HAUS augmin-like complex subunit 6 (HAUS6) OT7ZVR57 HAUS6_HUMAN Increases Expression [6]
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase (PIP4P1) OT991XS0 PP4P1_HUMAN Decreases Expression [6]
Kinectin (KTN1) OTQAV541 KTN1_HUMAN Increases Expression [6]
Phosphatidylcholine:ceramide cholinephosphotransferase 1 (SGMS1) OTZQE7PW SMS1_HUMAN Increases Expression [6]
Sodium-independent sulfate anion transporter (SLC26A11) OTWBV9CR S2611_HUMAN Increases Expression [6]
RNA-binding protein MEX3D (MEX3D) OTAUWRK7 MEX3D_HUMAN Decreases Expression [6]
Dynein axonemal assembly factor 5 (DNAAF5) OTN0CT52 DAAF5_HUMAN Decreases Expression [6]
Syntaxin-12 (STX12) OT5IBQ62 STX12_HUMAN Increases Expression [6]
Mitogen-activated protein kinase kinase kinase kinase 3 (MAP4K3) OTNJX38T M4K3_HUMAN Increases Expression [6]
Protein FAM219A (FAM219A) OTAFZHY9 F219A_HUMAN Increases Expression [6]
Mitofusin-1 (MFN1) OTCBXQZF MFN1_HUMAN Decreases Expression [6]
Pleckstrin homology domain-containing family M member 2 (PLEKHM2) OT4ZYV73 PKHM2_HUMAN Decreases Expression [6]
Mitochondrial Rho GTPase 2 (RHOT2) OTV8WT2L MIRO2_HUMAN Decreases Expression [6]
Xaa-Arg dipeptidase (PM20D2) OTD2Y7LU P20D2_HUMAN Increases Expression [6]
Solute carrier family 38 member 6 (SLC38A6) OTIC8SHQ S38A6_HUMAN Increases Expression [6]
Abl interactor 1 (ABI1) OT5H4M62 ABI1_HUMAN Increases Expression [6]
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase (GCNT2) OTRUIMC4 GNT2A_HUMAN Increases Expression [6]
Protein FAM43A (FAM43A) OT5RPQRE FA43A_HUMAN Decreases Expression [6]
CAP-Gly domain-containing linker protein 4 (CLIP4) OT75KVQK CLIP4_HUMAN Increases Expression [6]
Putative transporter SVOPL (SVOPL) OTJ4G2ND SVOPL_HUMAN Decreases Expression [6]
Polypeptide N-acetylgalactosaminyltransferase 4 (GALNT4) OT6WKC13 GALT4_HUMAN Increases Expression [6]
Coiled-coil domain-containing protein 82 (CCDC82) OT16EAZ7 CCD82_HUMAN Increases Expression [6]
SH2 domain-containing protein 3C (SH2D3C) OTAGXO0N SH2D3_HUMAN Decreases Expression [6]
Methyltransferase-like protein 27 (METTL27) OTOF0GTU MET27_HUMAN Decreases Expression [6]
ADP-ribosylation factor GTPase-activating protein 1 (ARFGAP1) OTM3KHIE ARFG1_HUMAN Decreases Expression [6]
Protein KRI1 homolog (KRI1) OT1IGOK7 KRI1_HUMAN Increases Expression [6]
ATPase family gene 2 protein homolog A (AFG2A) OTPZKWN7 AFG2A_HUMAN Increases Expression [6]
Equilibrative nucleobase transporter 1 (SLC43A3) OTR60ZLA S43A3_HUMAN Decreases Expression [6]
Retinol dehydrogenase 13 (RDH13) OT48VJ65 RDH13_HUMAN Increases Expression [6]
Neuropilin and tolloid-like protein 2 (NETO2) OT0YAMC0 NETO2_HUMAN Decreases Expression [6]
Polyhomeotic-like protein 3 (PHC3) OTTTLIAP PHC3_HUMAN Increases Expression [6]
Glutathione S-transferase C-terminal domain-containing protein (GSTCD) OTIIINMT GSTCD_HUMAN Decreases Expression [6]
Folliculin (FLCN) OTVM78XM FLCN_HUMAN Increases Expression [6]
Tubulin--tyrosine ligase (TTL) OTSS1CK4 TTL_HUMAN Decreases Expression [6]
Protein NEDD1 (NEDD1) OTBD6X77 NEDD1_HUMAN Increases Expression [6]
Protein FAM76A (FAM76A) OT28WHO4 FA76A_HUMAN Increases Expression [6]
Proline-rich protein 7 (PRR7) OT56XAQK PRR7_HUMAN Decreases Expression [6]
Transmembrane protein 254 (TMEM254) OTGDPU8S TM254_HUMAN Decreases Expression [6]
Retinol dehydrogenase 11 (RDH11) OTIND43N RDH11_HUMAN Increases Expression [6]
POC1 centriolar protein homolog B (POC1B) OTDIMIRZ POC1B_HUMAN Increases Expression [6]
Interferon-induced protein 44 (IFI44) OTOKSZVA IFI44_HUMAN Increases Expression [6]
Large ribosomal subunit protein uL30m (MRPL30) OT26OPYV RM30_HUMAN Decreases Expression [6]
RB1-inducible coiled-coil protein 1 (RB1CC1) OTZK8PFX RBCC1_HUMAN Increases Expression [6]
Elongator complex protein 5 (ELP5) OTW5R7YD ELP5_HUMAN Decreases Expression [6]
DDB1- and CUL4-associated factor 11 (DCAF11) OTNSGYK1 DCA11_HUMAN Decreases Expression [6]
Arginine/serine-rich protein PNISR (PNISR) OTUM02FW PNISR_HUMAN Increases Expression [6]
General transcription factor 3C polypeptide 2 (GTF3C2) OTWDANLJ TF3C2_HUMAN Decreases Expression [6]
Transmembrane protein 263 (TMEM263) OTO1RSTS TM263_HUMAN Increases Expression [6]
Protein THEM6 (THEM6) OT51SVLH THEM6_HUMAN Decreases Expression [6]
Pleckstrin homology-like domain family A member 1 (PHLDA1) OTFTWMIQ PHLA1_HUMAN Increases Expression [6]
Hexosaminidase D (HEXD) OTTMQKLM HEXD_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase RNF138 (RNF138) OTPU0CO4 RN138_HUMAN Increases Expression [6]
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) OTA6Q5E0 HNRLL_HUMAN Increases Expression [6]
Uncharacterized protein C4orf3 (C4ORF3) OT6TFN1O CD003_HUMAN Decreases Expression [6]
tRNA-splicing endonuclease subunit Sen15 (TSEN15) OT14UW31 SEN15_HUMAN Decreases Expression [6]
Palladin (PALLD) OTZ2MUJZ PALLD_HUMAN Increases Expression [6]
Protein N-lysine methyltransferase METTL21A (METTL21A) OTXJTNXY MT21A_HUMAN Increases Expression [6]
Histone acetyltransferase KAT6B (KAT6B) OTMUDTAH KAT6B_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase rififylin (RFFL) OT85MGDH RFFL_HUMAN Increases Expression [6]
Aquaporin-3 (AQP3) OT2J7JPD AQP3_HUMAN Increases Expression [6]
Proteasome inhibitor PI31 subunit (PSMF1) OTX84WLQ PSMF1_HUMAN Decreases Expression [6]
Protein FAM168A (FAM168A) OTDXQCS5 F168A_HUMAN Increases Expression [6]
Protein NDRG1 (NDRG1) OTVO66BO NDRG1_HUMAN Increases Expression [6]
TRAF family member-associated NF-kappa-B activator (TANK) OTZSGFIK TANK_HUMAN Increases Expression [6]
Ras-related protein Rab-8B (RAB8B) OTBPUHV9 RAB8B_HUMAN Decreases Expression [6]
GTP-binding protein Rit1 (RIT1) OTVNOGOH RIT1_HUMAN Increases Expression [6]
Phosphorylase b kinase regulatory subunit beta (PHKB) OTKXZZIU KPBB_HUMAN Increases Expression [6]
BLOC-2 complex member HPS3 (HPS3) OTAKROK7 HPS3_HUMAN Decreases Expression [6]
F-box/WD repeat-containing protein 7 (FBXW7) OTJXE4OT FBXW7_HUMAN Decreases Expression [6]
Polyamine deacetylase HDAC10 (HDAC10) OTHCKKUQ HDA10_HUMAN Decreases Expression [6]
NXPE family member 3 (NXPE3) OTLVZ8W2 NXPE3_HUMAN Increases Expression [6]
Transmembrane protein 230 (TMEM230) OTAFALFV TM230_HUMAN Decreases Expression [6]
SOSS complex subunit B2 (NABP1) OTFTNFHW SOSB2_HUMAN Increases Expression [6]
Ankyrin repeat domain-containing protein 9 (ANKRD9) OT7VGO6G ANKR9_HUMAN Increases Expression [6]
ADP-ribosylation factor-like protein 8A (ARL8A) OTEYM6FA ARL8A_HUMAN Increases Expression [6]
m7GpppX diphosphatase (DCPS) OT1FZVC9 DCPS_HUMAN Decreases Expression [6]
Protein FAM241B (FAM241B) OTLISLRC F241B_HUMAN Increases Expression [6]
R3H domain-containing protein 4 (R3HDM4) OTE0Q78Q R3HD4_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase CHFR (CHFR) OTRAD2TT CHFR_HUMAN Decreases Expression [6]
ATP-dependent DNA helicase DDX11 (DDX11) OT1WR3MD DDX11_HUMAN Decreases Expression [6]
Kelch domain-containing protein 7B (KLHDC7B) OT2H5BNX KLD7B_HUMAN Increases Expression [6]
H/ACA ribonucleoprotein complex non-core subunit NAF1 (NAF1) OTMJKJAK NAF1_HUMAN Increases Expression [6]
Histone-lysine N-methyltransferase EHMT2 (EHMT2) OTC4DWB6 EHMT2_HUMAN Decreases Expression [6]
Uncharacterized protein C9orf85 (C9ORF85) OTJWBPL3 CI085_HUMAN Increases Expression [6]
Pannexin-2 (PANX2) OTAQ2S8R PANX2_HUMAN Increases Expression [6]
Ribosomal protein S6 kinase delta-1 (RPS6KC1) OT2LRTG4 KS6C1_HUMAN Increases Expression [6]
Structural maintenance of chromosomes protein 6 (SMC6) OT3IBHQD SMC6_HUMAN Increases Expression [6]
Protein orai-2 (ORAI2) OTYISRYH ORAI2_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase RING2 (RNF2) OTFPLOIN RING2_HUMAN Increases Expression [6]
Krueppel-like factor 6 (KLF6) OTQY9S7F KLF6_HUMAN Increases Expression [6]
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial (SDHC) OTC8G2MX C560_HUMAN Decreases Expression [6]
Sigma non-opioid intracellular receptor 1 (SIGMAR1) OTDORW5C SGMR1_HUMAN Decreases Expression [6]
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1A) OTVTB5R5 PI51A_HUMAN Decreases Expression [6]
Apolipoprotein L4 (APOL4) OTTOH86V APOL4_HUMAN Decreases Expression [6]
Protein NipSnap homolog 1 (NIPSNAP1) OTKXKUT8 NIPS1_HUMAN Decreases Expression [6]
Protein FAM118B (FAM118B) OTRLY4B0 F118B_HUMAN Increases Expression [6]
Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) OTYKB9G3 SIN1_HUMAN Decreases Expression [6]
TM2 domain-containing protein 3 (TM2D3) OT6MS96W TM2D3_HUMAN Increases Expression [6]
Ferroptosis suppressor protein 1 (AIFM2) OT57XWXO FSP1_HUMAN Increases Expression [6]
Tubulin-specific chaperone D (TBCD) OTS4JKNQ TBCD_HUMAN Decreases Expression [6]
Iron-sulfur cluster assembly 1 homolog, mitochondrial (ISCA1) OTU230MC ISCA1_HUMAN Increases Expression [6]
Bublin coiled-coil protein (BBLN) OTUMVEWE BBLN_HUMAN Decreases Expression [6]
Coiled-coil domain-containing protein 32 (CCDC32) OTPPUFIF CCD32_HUMAN Increases Expression [6]
Kinesin-like protein KIFC1 (KIFC1) OTNQDS00 KIFC1_HUMAN Decreases Expression [6]
Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) OTBUZ7KA KATL1_HUMAN Increases Expression [6]
Protein C1orf43 (C1ORF43) OTT9CVZR CA043_HUMAN Decreases Expression [6]
TM2 domain-containing protein 2 (TM2D2) OTB51WEY TM2D2_HUMAN Increases Expression [6]
Sphingosine-1-phosphate phosphatase 1 (SGPP1) OT9X54CQ SGPP1_HUMAN Increases Expression [6]
FSD1-like protein (FSD1L) OTBQ48RF FSD1L_HUMAN Increases Expression [6]
C-type lectin domain family 7 member A (CLEC7A) OTRTBH27 CLC7A_HUMAN Increases Expression [6]
Serrate RNA effector molecule homolog (SRRT) OTMYPSWV SRRT_HUMAN Decreases Expression [6]
Protein kinase C and casein kinase substrate in neurons protein 1 (PACSIN1) OT07Z2RQ PACN1_HUMAN Increases Expression [6]
Sterile alpha motif domain-containing protein 10 (SAMD10) OTBKWB5C SAM10_HUMAN Decreases Expression [6]
ATP-binding cassette sub-family A member 2 (ABCA2) OTVSYK0X ABCA2_HUMAN Decreases Expression [6]
INO80 complex subunit B (INO80B) OTSHV8JF IN80B_HUMAN Decreases Expression [6]
Uncharacterized protein C6orf62 (C6ORF62) OTGK4G35 CF062_HUMAN Increases Expression [6]
Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) OT4U7SBG GBRL1_HUMAN Increases Expression [6]
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 (NUCKS1) OTL4VJC5 NUCKS_HUMAN Decreases Expression [6]
Oxysterol-binding protein-related protein 2 (OSBPL2) OTCK671N OSBL2_HUMAN Increases Expression [6]
Dual specificity protein phosphatase 15 (DUSP15) OTS6PQYL DUS15_HUMAN Decreases Expression [6]
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) OT5HFZXU BACD3_HUMAN Increases Expression [6]
UPF0696 protein C11orf68 (C11ORF68) OTOKOGZ6 CK068_HUMAN Decreases Expression [6]
Differentially expressed in FDCP 6 homolog (DEF6) OTIRBYVK DEFI6_HUMAN Decreases Expression [6]
Sentrin-specific protease 3 (SENP3) OTFQDOMC SENP3_HUMAN Decreases Expression [6]
ESF1 homolog (ESF1) OTHEDM0A ESF1_HUMAN Increases Expression [6]
RNA polymerase II-associated protein 3 (RPAP3) OTCW17LF RPAP3_HUMAN Increases Expression [6]
Sin3 histone deacetylase corepressor complex component SDS3 (SUDS3) OTZ1AARI SDS3_HUMAN Increases Expression [6]
Caspase activity and apoptosis inhibitor 1 (CAAP1) OTD2DN1Z CAAP1_HUMAN Increases Expression [6]
Kinesin-like protein KIF9 (KIF9) OT7W6VI1 KIF9_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase SMURF2 (SMURF2) OT3TRVL7 SMUF2_HUMAN Increases Expression [6]
Transcription factor IIIB 50 kDa subunit (BRF2) OT2C6TH2 BRF2_HUMAN Increases Expression [6]
Retinoid-inducible serine carboxypeptidase (SCPEP1) OT43LYEZ RISC_HUMAN Increases Expression [6]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1) OT0X9WGR PATZ1_HUMAN Decreases Expression [6]
DNA dC->dU-editing enzyme APOBEC-3G (APOBEC3G) OT410VP5 ABC3G_HUMAN Increases Expression [6]
DnaJ homolog subfamily C member 4 (DNAJC4) OT4BUBQU DNJC4_HUMAN Decreases Expression [6]
DNA-directed DNA/RNA polymerase mu (POLM) OT0SRIP4 DPOLM_HUMAN Decreases Expression [6]
Carbohydrate sulfotransferase 11 (CHST11) OTNJJ5Q1 CHSTB_HUMAN Decreases Expression [6]
Uncharacterized protein C14orf132 (C14ORF132) OTBVC3AO CN132_HUMAN Decreases Expression [6]
Putative RNA-binding protein Luc7-like 1 (LUC7L) OT77JDB7 LUC7L_HUMAN Increases Expression [6]
Prefoldin subunit 4 (PFDN4) OT5NRHER PFD4_HUMAN Increases Expression [6]
Solute carrier family 35 member C2 (SLC35C2) OT9H15XZ S35C2_HUMAN Decreases Expression [6]
Gephyrin (GPHN) OTAKK1SV GEPH_HUMAN Decreases Expression [6]
Endophilin-B2 (SH3GLB2) OTF7BB9S SHLB2_HUMAN Decreases Expression [6]
Muscleblind-like protein 1 (MBNL1) OTOV7J85 MBNL1_HUMAN Decreases Expression [6]
CDC42 small effector protein 2 (CDC42SE2) OT8SG9I1 C42S2_HUMAN Decreases Expression [6]
RNA-binding protein PNO1 (PNO1) OT010GIS PNO1_HUMAN Increases Expression [6]
DDB1- and CUL4-associated factor 13 (DCAF13) OTQQ0QXT DCA13_HUMAN Increases Expression [6]
FGFR1 oncogene partner 2 (FGFR1OP2) OTAHO1ZC FGOP2_HUMAN Increases Expression [6]
DNA-directed RNA polymerase III subunit RPC5 (POLR3E) OT69PWBM RPC5_HUMAN Increases Expression [6]
Anoctamin-10 (ANO10) OTG3BNOU ANO10_HUMAN Increases Expression [6]
BSD domain-containing protein 1 (BSDC1) OT853CP9 BSDC1_HUMAN Increases Expression [6]
G patch domain-containing protein 2-like (GPATCH2L) OTETUZ64 GPT2L_HUMAN Increases Expression [6]
Ceroid-lipofuscinosis neuronal protein 6 (CLN6) OT91IAYT CLN6_HUMAN Decreases Expression [6]
AFG2-interacting ribosome maturation factor (AIRIM) OTGG814L AIRIM_HUMAN Increases Expression [6]
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2) OTE69HV8 B3GN2_HUMAN Decreases Expression [6]
Opioid growth factor receptor (OGFR) OTROS6RJ OGFR_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase KCMF1 (KCMF1) OTVTKFAU KCMF1_HUMAN Increases Expression [6]
Stromal interaction molecule 2 (STIM2) OTYNXAW0 STIM2_HUMAN Decreases Expression [6]
Inhibitor of Bruton tyrosine kinase (IBTK) OTB2GM4G IBTK_HUMAN Increases Expression [6]
Phosphatidylinositol 4-kinase beta (PI4KB) OTI9UQSU PI4KB_HUMAN Decreases Expression [6]
E3 ubiquitin-protein ligase RNF14 (RNF14) OTWX0D0H RNF14_HUMAN Increases Expression [6]
Fibulin-5 (FBLN5) OTLVNZ8U FBLN5_HUMAN Decreases Expression [6]
Beta-1,4-galactosyltransferase 6 (B4GALT6) OTBM8F2U B4GT6_HUMAN Increases Expression [6]
LIM domain-containing protein 1 (LIMD1) OTN1CG6R LIMD1_HUMAN Increases Expression [6]
Protein NDRG3 (NDRG3) OTJTJCHD NDRG3_HUMAN Decreases Expression [6]
LIM domain and actin-binding protein 1 (LIMA1) OTONPC9R LIMA1_HUMAN Increases Expression [6]
AF4/FMR2 family member 4 (AFF4) OTTL5Y8R AFF4_HUMAN Increases Expression [6]
NADH-cytochrome b5 reductase 1 (CYB5R1) OTMDHMLA NB5R1_HUMAN Increases Expression [6]
Methyl-CpG-binding domain protein 1 (MBD1) OTD19VO6 MBD1_HUMAN Decreases Expression [6]
Oxidative stress-induced growth inhibitor 1 (OSGIN1) OT9KIVZW OSGI1_HUMAN Increases Expression [6]
Cell division cycle protein 23 homolog (CDC23) OTC4O83E CDC23_HUMAN Increases Expression [6]
Anaphase-promoting complex subunit 5 (ANAPC5) OTGTJNNR APC5_HUMAN Decreases Expression [6]
Calcipressin-3 (RCAN3) OTTS3CQA RCAN3_HUMAN Decreases Expression [6]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 (ASAP1) OT4DLRYY ASAP1_HUMAN Decreases Expression [6]
Tetratricopeptide repeat protein 7A (TTC7A) OTDHLPQM TTC7A_HUMAN Decreases Expression [6]
Nucleosome assembly protein 1-like 2 (NAP1L2) OT8QI4GF NP1L2_HUMAN Increases Expression [6]
Protein PHTF1 (PHTF1) OTYCZ84A PHTF1_HUMAN Increases Expression [6]
26S proteasome non-ATPase regulatory subunit 13 (PSMD13) OTNQ351N PSD13_HUMAN Increases Expression [6]
Cytosolic carboxypeptidase 1 (AGTPBP1) OTR92JFR CBPC1_HUMAN Increases Expression [6]
Serine/threonine-protein kinase ICK (CILK1) OTWOYEYP CILK1_HUMAN Increases Expression [6]
Structural maintenance of chromosomes protein 3 (SMC3) OTWGFRHD SMC3_HUMAN Increases Expression [6]
Myotubularin-related protein 6 (MTMR6) OTQPAWI3 MTMR6_HUMAN Increases Expression [6]
Phospholipase A-2-activating protein (PLAA) OTZ7NJGA PLAP_HUMAN Increases Expression [6]
Phenylalanine--tRNA ligase alpha subunit (FARSA) OT3U1P20 SYFA_HUMAN Decreases Expression [6]
Nck-associated protein 1 (NCKAP1) OTEZQXXJ NCKP1_HUMAN Increases Expression [6]
Kelch-like protein 20 (KLHL20) OTC0SFS9 KLH20_HUMAN Increases Expression [6]
ARF GTPase-activating protein GIT1 (GIT1) OTHO92S5 GIT1_HUMAN Decreases Expression [6]
RING finger protein 11 (RNF11) OTFBJSKQ RNF11_HUMAN Increases Expression [6]
Transformation/transcription domain-associated protein (TRRAP) OT68OI2Y TRRAP_HUMAN Decreases Expression [6]
Carbohydrate sulfotransferase 2 (CHST2) OTV11IZF CHST2_HUMAN Decreases Expression [6]
G-protein-signaling modulator 3 (GPSM3) OT2MO458 GPSM3_HUMAN Decreases Expression [6]
U6 snRNA-associated Sm-like protein LSm4 (LSM4) OTLKJB3A LSM4_HUMAN Decreases Expression [6]
DNA-directed RNA polymerase III subunit RPC8 (POLR3H) OT7GM7MX RPC8_HUMAN Decreases Expression [6]
NEDD8 ultimate buster 1 (NUB1) OTWA6RTX NUB1_HUMAN Increases Expression [6]
Selenoprotein K (SELENOK) OTKM7N7P SELK_HUMAN Increases Expression [6]
Nuclear receptor coactivator 3 (NCOA3) OTBX300Z NCOA3_HUMAN Increases Expression [6]
Numb-like protein (NUMBL) OTWMTMMH NUMBL_HUMAN Increases Expression [6]
ATPase MORC2 (MORC2) OT52A8BJ MORC2_HUMAN Increases Expression [6]
Aldo-keto reductase family 1 member B10 (AKR1B10) OTOA4HTH AK1BA_HUMAN Increases Expression [20]
Aldo-keto reductase family 1 member B1 (AKR1B1) OTRX72TH ALDR_HUMAN Increases Expression [20]
Prostaglandin G/H synthase 2 (PTGS2) OT75U9M4 PGH2_HUMAN Increases Expression [20]
Aldo-keto reductase family 1 member C3 (AKR1C3) OTU2SXBA AK1C3_HUMAN Increases Expression [20]
Aldo-keto reductase family 1 member C2 (AKR1C2) OTQ2XMO3 AK1C2_HUMAN Affects Expression [20]
Aldo-keto reductase family 1 member C1 (AKR1C1) OTQKR4CM AK1C1_HUMAN Increases Expression [20]
ATP-binding cassette sub-family C member 2 (ABCC2) OTJSIGV5 MRP2_HUMAN Increases Expression [20]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Increases Expression [21]
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) OTBPCU2O TR10A_HUMAN Decreases Expression [22]
NF-kappa-B inhibitor epsilon (NFKBIE) OTLAYEL9 IKBE_HUMAN Increases Stability [23]
Myc box-dependent-interacting protein 1 (BIN1) OTK8O0X8 BIN1_HUMAN Increases Expression [11]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) OTA1CPBV TR10B_HUMAN Increases Expression [24]
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) OT9RDS3H IKKB_HUMAN Decreases Expression [9]
Inhibitor of nuclear factor kappa-B kinase subunit alpha (CHUK) OTLF4ZB1 IKKA_HUMAN Increases Expression [9]
Apoptosis regulatory protein Siva (SIVA1) OTDT0XZK SIVA_HUMAN Decreases Expression [11]
Baculoviral IAP repeat-containing protein 5 (BIRC5) OTILXZYL BIRC5_HUMAN Decreases Expression [25]
High affinity copper uptake protein 1 (SLC31A1) OTXLRTUB COPT1_HUMAN Decreases Degradation [26]
CASP8 and FADD-like apoptosis regulator (CFLAR) OTX14BAS CFLAR_HUMAN Decreases Expression [11]
Histone-lysine N-methyltransferase SUV39H1 (SUV39H1) OTDTF5BU SUV91_HUMAN Decreases Expression [11]
Serine protease HTRA2, mitochondrial (HTRA2) OTC7616F HTRA2_HUMAN Affects Localization [27]
Bcl-2-like protein 11 (BCL2L11) OTNQQWFJ B2L11_HUMAN Increases Activity [28]
Nuclear protein 1 (NUPR1) OT4FU8C0 NUPR1_HUMAN Increases Expression [29]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [9]
DENN domain-containing protein 4B (DENND4B) OTFEO8KG DEN4B_HUMAN Increases Expression [30]
Growth arrest and DNA damage-inducible protein GADD45 beta (GADD45B) OTL9I7LO GA45B_HUMAN Increases Expression [30]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) OTYG179K PR15A_HUMAN Increases Expression [30]
Natural cytotoxicity triggering receptor 1 (NCR1) OT6MZKQY NCTR1_HUMAN Decreases Expression [31]
Growth arrest and DNA damage-inducible protein GADD45 gamma (GADD45G) OT8V1J4M GA45G_HUMAN Increases Expression [25]
BAG family molecular chaperone regulator 3 (BAG3) OTVXYUDQ BAG3_HUMAN Increases Expression [30]
Apoptosis-inducing factor 1, mitochondrial (AIFM1) OTKPWB7Q AIFM1_HUMAN Affects Localization [27]
Myc proto-oncogene protein (MYC) OTPV5LUK MYC_HUMAN Decreases Expression [32]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Decreases Response To Substance [33]
Prelamin-A/C (LMNA) OT3SG7ZR LMNA_HUMAN Increases Cleavage [34]
RAF proto-oncogene serine/threonine-protein kinase (RAF1) OT51LSFO RAF1_HUMAN Decreases Expression [35]
Receptor tyrosine-protein kinase erbB-2 (ERBB2) OTOAUNCK ERBB2_HUMAN Decreases Phosphorylation [36]
Cellular tumor antigen p53 (TP53) OTIE1VH3 P53_HUMAN Increases Activity [37]
Galectin-2 (LGALS2) OTY08TMQ LEG2_HUMAN Decreases Expression [11]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1) OTM0GDTP IF2A_HUMAN Increases Phosphorylation [38]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [39]
Intercellular adhesion molecule 1 (ICAM1) OTTOIX77 ICAM1_HUMAN Decreases Expression [9]
Transcription factor Jun (JUN) OTCYBO6X JUN_HUMAN Decreases Expression [9]
Cyclin-dependent kinase 1 (CDK1) OTW1SC2N CDK1_HUMAN Decreases Activity [7]
Integrin alpha-V (ITGAV) OTAM7JTR ITAV_HUMAN Increases Expression [9]
Cathepsin B (CTSB) OTP9G5QB CATB_HUMAN Increases Localization [28]
Heat shock protein HSP 90-alpha (HSP90AA1) OTLG1WPK HS90A_HUMAN Decreases Expression [9]
Heat shock protein HSP 90-beta (HSP90AB1) OTR69EG7 HS90B_HUMAN Increases Expression [21]
Growth-regulated alpha protein (CXCL1) OT3WCTZV GROA_HUMAN Increases Expression [30]
Heme oxygenase 1 (HMOX1) OTC1W6UX HMOX1_HUMAN Increases Expression [30]
Poly polymerase 1 (PARP1) OT310QSG PARP1_HUMAN Increases Cleavage [40]
Heat shock 70 kDa protein 1A (HSPA1A) OTKGIE76 HS71A_HUMAN Increases Expression [21]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Increases Expression [30]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Decreases Expression [41]
Cytochrome c oxidase subunit 8A, mitochondrial (COX8A) OTU0NR39 COX8A_HUMAN Decreases Expression [37]
Apoptosis regulator Bcl-2 (BCL2) OT9DVHC0 BCL2_HUMAN Decreases Expression [42]
Osteopontin (SPP1) OTJGC23Y OSTP_HUMAN Decreases Expression [9]
Growth hormone receptor (GHR) OT8WUWMU GHR_HUMAN Increases Expression [21]
Parathyroid hormone-related protein (PTHLH) OTI1JF13 PTHR_HUMAN Decreases Expression [41]
Interferon-induced transmembrane protein 1 (IFITM1) OTECO1G8 IFM1_HUMAN Decreases Expression [11]
Protein Cripto (CRIPTO) OT46DZXJ TDGF1_HUMAN Increases Expression [21]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [9]
Tissue factor (F3) OT3MSU3B TF_HUMAN Increases Expression [43]
G2/mitotic-specific cyclin-B1 (CCNB1) OT19S7E5 CCNB1_HUMAN Increases Expression [44]
Interleukin-1 receptor type 1 (IL1R1) OTTU8959 IL1R1_HUMAN Increases Expression [21]
Transcription factor 4 (TCF4) OTB9ASTK ITF2_HUMAN Increases Expression [21]
Histone H2AX (H2AX) OT18UX57 H2AX_HUMAN Decreases Phosphorylation [45]
Interleukin-7 receptor subunit alpha (IL7R) OTBMFLQQ IL7RA_HUMAN Increases Expression [9]
Heat shock 70 kDa protein 6 (HSPA6) OTH4S7WB HSP76_HUMAN Increases Expression [30]
Transcription factor JunB (JUNB) OTG2JXV5 JUNB_HUMAN Decreases Expression [46]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Decreases Expression [9]
Early growth response protein 1 (EGR1) OTCP6XGZ EGR1_HUMAN Increases Expression [9]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3) OTC1UOHP ATF3_HUMAN Increases Expression [25]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) OTRFV19J ATF4_HUMAN Increases Expression [30]
Nuclear factor NF-kappa-B p105 subunit (NFKB1) OTNRRD8I NFKB1_HUMAN Decreases Expression [47]
Interleukin-10 (IL10) OTIRFRXC IL10_HUMAN Affects Expression [22]
Cyclin-dependent kinase 2 (CDK2) OTB5DYYZ CDK2_HUMAN Decreases Activity [7]
Tumor necrosis factor receptor superfamily member 6 (FAS) OTP9XG86 TNR6_HUMAN Decreases Expression [9]
DnaJ homolog subfamily B member 1 (DNAJB1) OTCOSEVH DNJB1_HUMAN Increases Expression [30]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [21]
Pentraxin-related protein PTX3 (PTX3) OTPXHRKU PTX3_HUMAN Decreases Expression [9]
CD27 antigen (CD27) OTH7NA58 CD27_HUMAN Increases Expression [21]
Mitogen-activated protein kinase 3 (MAPK3) OTCYKGKO MK03_HUMAN Decreases Activity [35]
Calreticulin (CALR) OTYD2TR1 CALR_HUMAN Increases Expression [19]
Mitogen-activated protein kinase 1 (MAPK1) OTH85PI5 MK01_HUMAN Decreases Activity [35]
Tyrosine-protein phosphatase non-receptor type 6 (PTPN6) OT33XNZM PTN6_HUMAN Decreases Expression [11]
SHC-transforming protein 1 (SHC1) OT1J5IRN SHC1_HUMAN Decreases Expression [9]
Nitric oxide synthase 1 (NOS1) OT7M8XVG NOS1_HUMAN Increases Expression [19]
RAC-alpha serine/threonine-protein kinase (AKT1) OT8H2YY7 AKT1_HUMAN Decreases Activity [35]
DNA replication licensing factor MCM7 (MCM7) OT6FXC6K MCM7_HUMAN Decreases Expression [11]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Expression [48]
Replication protein A 14 kDa subunit (RPA3) OT8JAQGL RFA3_HUMAN Decreases Expression [11]
Pro-adrenomedullin (ADM) OT7T0TA4 ADML_HUMAN Decreases Expression [9]
Insulin receptor substrate 1 (IRS1) OTNO82CU IRS1_HUMAN Decreases Degradation [49]
DNA damage-inducible transcript 3 protein (DDIT3) OTI8YKKE DDIT3_HUMAN Increases Expression [11]
Alpha-synuclein (SNCA) OTPWC1MR SYUA_HUMAN Increases Expression [21]
Breast cancer type 1 susceptibility protein (BRCA1) OT5BN6VH BRCA1_HUMAN Decreases Expression [50]
Cyclin-dependent kinase inhibitor 1 (CDKN1A) OTQWHCZE CDN1A_HUMAN Increases Expression [25]
Small ribosomal subunit protein eS19 (RPS19) OTBKGP48 RS19_HUMAN Increases Expression [30]
Caspase-3 (CASP3) OTIJRBE7 CASP3_HUMAN Increases Activity [38]
Caspase-2 (CASP2) OTUDYSPP CASP2_HUMAN Increases Cleavage [30]
Mitogen-activated protein kinase 8 (MAPK8) OTEREYS5 MK08_HUMAN Increases Phosphorylation [51]
Mitogen-activated protein kinase 9 (MAPK9) OTCEVJ9E MK09_HUMAN Increases Phosphorylation [51]
Proliferation marker protein Ki-67 (MKI67) OTA8N1QI KI67_HUMAN Decreases Expression [52]
Cyclin-dependent kinase inhibitor 1B (CDKN1B) OTNY5LLZ CDN1B_HUMAN Increases Expression [7]
Tumor necrosis factor ligand superfamily member 6 (FASLG) OTZARCHH TNFL6_HUMAN Increases Expression [53]
Caspase-4 (CASP4) OTVQTV1L CASP4_HUMAN Increases Activity [38]
Isocitrate dehydrogenase subunit alpha, mitochondrial (IDH3A) OT5QQB5L IDH3A_HUMAN Decreases Expression [37]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10) OT4PXBTA TNF10_HUMAN Decreases Expression [54]
Small ribosomal subunit protein mS29 (DAP3) OTNPEZYM RT29_HUMAN Increases Expression [11]
Breast cancer type 2 susceptibility protein (BRCA2) OTF1XSV1 BRCA2_HUMAN Decreases Expression [50]
Interleukin-1 receptor-associated kinase 1 (IRAK1) OT133G8J IRAK1_HUMAN Decreases Expression [9]
DNA mismatch repair protein Msh6 (MSH6) OT46FP09 MSH6_HUMAN Decreases Expression [11]
Caspase-7 (CASP7) OTAPJ040 CASP7_HUMAN Increases Activity [55]
Caspase-6 (CASP6) OTXLD3EC CASP6_HUMAN Increases Cleavage [40]
Hepatocyte nuclear factor 3-alpha (FOXA1) OTEBY0TD FOXA1_HUMAN Decreases Expression [9]
BH3-interacting domain death agonist (BID) OTOSHSHU BID_HUMAN Increases Cleavage [25]
Histone deacetylase 4 (HDAC4) OTQNGD32 HDAC4_HUMAN Decreases Expression [11]
NACHT, LRR and PYD domains-containing protein 12 (NLRP12) OTGR132Z NAL12_HUMAN Increases Expression [9]
Beta-2-microglobulin (B2M) OTDWN6NX B2MG_HUMAN Decreases Expression [56]
C-C motif chemokine 8 (CCL8) OTCTWYN8 CCL8_HUMAN Affects Expression [22]
Cytochrome c (CYCS) OTBFALJD CYC_HUMAN Affects Localization [27]
Heat shock factor protein 1 (HSF1) OTYNJ4KP HSF1_HUMAN Increases Expression [21]
Nuclear factor NF-kappa-B p100 subunit (NFKB2) OTS231V7 NFKB2_HUMAN Decreases Expression [47]
E3 ubiquitin-protein ligase Mdm2 (MDM2) OTOVXARF MDM2_HUMAN Increases Cleavage [57]
Dystonin (DST) OTHZBM4X DYST_HUMAN Increases Expression [11]
Heat shock factor protein 2 (HSF2) OTXNJIJ9 HSF2_HUMAN Increases Expression [58]
DNA repair protein RAD51 homolog 1 (RAD51) OTNVWGC1 RAD51_HUMAN Decreases Expression [50]
Fragile X messenger ribonucleoprotein 1 (FMR1) OTWEV0T5 FMR1_HUMAN Decreases Expression [11]
Apoptosis regulator BAX (BAX) OTAW0V4V BAX_HUMAN Increases Expression [59]
Bcl-2-like protein 1 (BCL2L1) OTRC5K9O B2CL1_HUMAN Decreases Expression [28]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1) OT2YYI1A MCL1_HUMAN Increases Cleavage [40]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 (BNIP3) OT4SO7J4 BNIP3_HUMAN Increases Expression [34]
Baculoviral IAP repeat-containing protein 1 (NAIP) OTLA925F BIRC1_HUMAN Affects Expression [47]
Chromatin assembly factor 1 subunit A (CHAF1A) OTXSSY4H CAF1A_HUMAN Decreases Expression [11]
S-phase kinase-associated protein 2 (SKP2) OTD5B41X SKP2_HUMAN Decreases Expression [60]
Serine-protein kinase ATM (ATM) OTQVOHLT ATM_HUMAN Increases Cleavage [57]
Bcl-2-interacting killer (BIK) OTTH1T3D BIK_HUMAN Increases Activity [28]
Interleukin-18 receptor 1 (IL18R1) OT83XMPQ IL18R_HUMAN Increases Expression [21]
Baculoviral IAP repeat-containing protein 3 (BIRC3) OT3E95KB BIRC3_HUMAN Increases Expression [61]
Baculoviral IAP repeat-containing protein 2 (BIRC2) OTFXFREP BIRC2_HUMAN Decreases Expression [23]
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) OTC41R1E RIPK1_HUMAN Decreases Expression [9]
Cullin-1 (CUL1) OTXPE1UZ CUL1_HUMAN Increases Expression [21]
Cullin-3 (CUL3) OTDNOAPM CUL3_HUMAN Decreases Expression [11]
Phorbol-12-myristate-13-acetate-induced protein 1 (PMAIP1) OTXEE550 APR_HUMAN Decreases Expression [47]
Caspase-8 (CASP8) OTA8TVI8 CASP8_HUMAN Increases Cleavage [57]
Transcription elongation factor A protein-like 1 (TCEAL1) OTAPG2L5 TCAL1_HUMAN Increases Expression [21]
Interferon regulatory factor 4 (IRF4) OT1DHQ1P IRF4_HUMAN Decreases Expression [46]
Nuclear factor erythroid 2-related factor 2 (NFE2L2) OT0HENJ5 NF2L2_HUMAN Increases Activity [37]
Hsp90 co-chaperone Cdc37 (CDC37) OTYDT4A7 CDC37_HUMAN Increases Expression [21]
Bcl-2 homologous antagonist/killer (BAK1) OTDP6ILW BAK_HUMAN Increases Expression [62]
Hypoxia-inducible factor 1-alpha (HIF1A) OTADSC03 HIF1A_HUMAN Increases Expression [63]
Carbonic anhydrase 9 (CA9) OTNA51XT CAH9_HUMAN Decreases Expression [63]
TIR domain-containing adapter molecule 2 (TICAM2) OTK7GIJ5 TCAM2_HUMAN Increases Expression [9]
Cell division cycle and apoptosis regulator protein 1 (CCAR1) OTUXLQZZ CCAR1_HUMAN Increases Expression [64]
Ectodysplasin-A receptor-associated adapter protein (EDARADD) OT0G52MC EDAD_HUMAN Increases Expression [21]
DNA-binding death effector domain-containing protein 2 (DEDD2) OT0WXRWT DEDD2_HUMAN Increases Expression [11]
Heat shock protein 105 kDa (HSPH1) OTVRR73T HS105_HUMAN Increases Expression [25]
CREB-binding protein (CREBBP) OTPA4QGM CBP_HUMAN Decreases Expression [47]
Histone acetyltransferase KAT2B (KAT2B) OTWQITWK KAT2B_HUMAN Decreases Expression [9]
Bcl-2-like protein 2 (BCL2L2) OTMKVO0J B2CL2_HUMAN Increases Expression [65]
N-alpha-acetyltransferase 80 (NAA80) OTLWR71Z NAA80_HUMAN Decreases Expression [11]
MOB kinase activator 3A (MOB3A) OTILIOXF MOB3A_HUMAN Decreases Expression [11]
Baculoviral IAP repeat-containing protein 7 (BIRC7) OTITCGHB BIRC7_HUMAN Decreases Expression [66]
NACHT, LRR and PYD domains-containing protein 3 (NLRP3) OTZM6MHU NLRP3_HUMAN Decreases Expression [11]
Bcl-2-binding component 3, isoforms 3/4 (BBC3) OTUAXDAY BBC3B_HUMAN Increases Expression [67]
Tribbles homolog 3 (TRIB3) OTG5OS7X TRIB3_HUMAN Increases Expression [19]
Cell growth regulator with EF hand domain protein 1 (CGREF1) OTBZQX97 CGRE1_HUMAN Increases Expression [21]
Myeloid differentiation primary response protein MyD88 (MYD88) OTB4D6FL MYD88_HUMAN Decreases Expression [9]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1) OTJGE772 CHAC1_HUMAN Increases Expression [30]
Fanconi anemia group D2 protein (FANCD2) OTVEB5LF FACD2_HUMAN Decreases Expression [68]
Eukaryotic translation initiation factor 2A (EIF2A) OTWXELQP EIF2A_HUMAN Decreases Phosphorylation [69]
DNA replication factor Cdt1 (CDT1) OTVY53VG CDT1_HUMAN Decreases Expression [11]
Interleukin-23 subunit alpha (IL23A) OTYO99HC IL23A_HUMAN Increases Expression [21]
Transcription factor 7-like 2 (TCF7L2) OTVWPZ8B TF7L2_HUMAN Increases Expression [21]
Diablo IAP-binding mitochondrial protein (DIABLO) OTHJ9MCZ DBLOH_HUMAN Increases Expression [47]
Sphingosine kinase 1 (SPHK1) OTWYPBVD SPHK1_HUMAN Decreases Expression [70]
Anaphase-promoting complex subunit 11 (ANAPC11) OTK2SJXR APC11_HUMAN Decreases Expression [11]
Eukaryotic translation initiation factor 2-alpha kinase 3 (EIF2AK3) OT0DZGY4 E2AK3_HUMAN Increases Phosphorylation [30]
Lipid transferase CIDEB (CIDEB) OT873IYM CIDEB_HUMAN Decreases Expression [11]
Adenine DNA glycosylase (MUTYH) OTXTKI7Q MUTYH_HUMAN Decreases Expression [11]
Cell cycle progression protein 1 (CCPG1) OT0IHDKL CCPG1_HUMAN Increases Expression [9]
FAS-associated factor 1 (FAF1) OTGAMLM4 FAF1_HUMAN Increases Expression [21]
Transcription factor 19 (TCF19) OT7NKLF9 TCF19_HUMAN Decreases Expression [11]
Cyclic AMP-dependent transcription factor ATF-5 (ATF5) OT03QCLM ATF5_HUMAN Increases Expression [25]
Rho-related BTB domain-containing protein 2 (RHOBTB2) OT2DATFX RHBT2_HUMAN Increases Response To Substance [71]
Beclin-1 (BECN1) OT4X293M BECN1_HUMAN Decreases Response To Substance [72]
Palmitoyl thioesterase CPT1C (CPT1C) OT8F1MBF CPT1C_HUMAN Increases Response To Substance [71]
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) OT959A3A AT2A1_HUMAN Affects Response To Substance [73]
Histone deacetylase 6 (HDAC6) OT9W9MXQ HDAC6_HUMAN Decreases Response To Substance [74]
Serine/threonine-protein kinase 4 (STK4) OTBRYNNH STK4_HUMAN Increases Response To Substance [75]
Caspase-9 (CASP9) OTD4RFFG CASP9_HUMAN Increases Response To Substance [71]
Transcription factor SOX-8 (SOX8) OTEJXYZM SOX8_HUMAN Increases Response To Substance [71]
DNA repair endonuclease XPF (ERCC4) OTFIOPG1 XPF_HUMAN Increases Response To Substance [71]
Polyunsaturated fatty acid lipoxygenase ALOX12 (ALOX12) OTFL5KR5 LOX12_HUMAN Increases Response To Substance [71]
Heat shock protein beta-1 (HSPB1) OTHFZ8ED HSPB1_HUMAN Decreases Response To Substance [76]
Peroxisome proliferator-activated receptor delta (PPARD) OTI4WTOP PPARD_HUMAN Increases Response To Substance [71]
Superoxide dismutase , mitochondrial (SOD2) OTIWXGZ9 SODM_HUMAN Increases Response To Substance [71]
Unconventional myosin-Va (MYO5A) OTMWLP3E MYO5A_HUMAN Increases Response To Substance [71]
Proteasome subunit beta type-5 (PSMB5) OTOZXAS6 PSB5_HUMAN Decreases Response To Substance [77]
Retinoblastoma-associated protein (RB1) OTQJUJMZ RB_HUMAN Increases Response To Substance [78]
Mannose-binding protein C (MBL2) OTS63HG5 MBL2_HUMAN Increases Response To Substance [71]
Nucleophosmin (NPM1) OTTBYYT0 NPM_HUMAN Increases Response To Substance [79]
BRCA1-associated RING domain protein 1 (BARD1) OTTC0Z9Y BARD1_HUMAN Increases Response To Substance [78]
General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) OTVAW3P1 ERCC3_HUMAN Increases Response To Substance [71]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Increases Response To Substance [71]
Serine/threonine-protein kinase/endoribonuclease IRE1 (ERN1) OTY9R6FZ ERN1_HUMAN Decreases Response To Substance [38]
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⏷ Show the Full List of 686 DOT(s)

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adenocarcinoma DCDV9LV A549 Investigative [80]
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References

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