Details of the Drug Combination

General Information of Drug Combination (ID: DCPATV2)

Drug Combination Name

Clascoterone AS-1949490

Indication

Disease Entry	Status	REF
Chronic myelogenous leukemia	Investigative	[1]

Component Drugs

Clascoterone DMPGR1E

AS-1949490 DMZ1OO0

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: KBM-7

Zero Interaction Potency (ZIP) Score: 9.29

Bliss Independence Score: 9.29

Loewe Additivity Score: 21.82

LHighest Single Agent (HSA) Score: 21.82

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Clascoterone

Disease Entry	ICD 11	Status	REF
Acne vulgaris	ED80	Approved	[2]

Clascoterone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Antagonist	[2]
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Indication(s) of AS-1949490

Disease Entry	ICD 11	Status	REF
Non-insulin dependent diabetes	5A11	Investigative	[3]

References

1	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
3	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.