Details of the Drug Combination

General Information of Drug Combination (ID: DCPE56X)

• Drug Combination Name: Ipilimumab + Nivolumab
• Indication: Head and neck cancer; Mesothelioma; Renal cell carcinoma; Small-cell lung cancer; Solid tumour/cancer; Status: Phase 1 [1]
• Component Drugs:
  Ipilimumab (DMJTIYK): Monoclonal antibody
  Nivolumab (DMAB9QE): Monoclonal antibody

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Ipilimumab

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Approved	[2]

Ipilimumab Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Cytotoxic T-lymphocyte protein 4 (CTLA-4)	TTI2S1D	CTLA4_HUMAN	.	[8]

Indication(s) of Nivolumab

Disease Entry	ICD 11	Status	REF
Melanoma	2C30	Approved	[3]
Non-small-cell lung cancer	2C25.Y	Approved	[4]
Esophageal cancer	2B70	Phase 3	[5]
Gastric adenocarcinoma	2B72	Phase 3	[5]
Malignant pleural mesothelioma	2C26.0	Phase 3	[5]
Multiple myeloma	2A83	Phase 3	[5]
Recurrent glioblastoma	2A00.00	Phase 3	[5]
Small-cell lung cancer	2C25.Y	Phase 3	[5]
Central nervous system lymphoma	2B33.5	Phase 2	[5]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[6]
Diffuse large B-cell lymphoma	2A81	Phase 2	[5]
Follicular lymphoma	2A80	Phase 2	[5]
Prostate cancer	2C82.0	Phase 2	[5]
Ovarian cancer	2C73	Phase 1/2	[5]
Pancreatic cancer	2C10	Phase 1/2	[5]
Triple negative breast cancer	2C60-2C65	Phase 1/2	[5]
Chronic myelogenous leukaemia	2A20.0	Phase 1	[5]
Renal cell carcinoma	2C90	Application submitted	[5]
Lung squamous cell carcinoma	2C25.2	Investigative	[7]

Nivolumab Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Programmed cell death protein 1 (PD-1)	TTNBFWK	PDCD1_HUMAN	Modulator	[9]

References

• [1] FDA Drug Development and Drug Interactions
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6888).
• [3] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7335).
• [4] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
• [5] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [6] COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1
• [7] The Current Landscape of Immune Checkpoint Blockade in Metastatic Lung Squamous Cell Carcinoma. Molecules. 2021 Mar 5;26(5):1392.
• [8] Mullard A: 2010 FDA drug approvals. Nat Rev Drug Discov. 2011 Feb;10(2):82-5.
• [9] 2014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.