Details of the Drug Combination

General Information of Drug Combination (ID: DCR5528)

Drug Combination Name
BIO-300 Aminolevulinic Acid Hydrochloride
Indication
Disease Entry Status REF
Glioma Investigative [1]
Component Drugs BIO-300   DMJ7NVI Aminolevulinic Acid Hydrochloride   DMWNHPC
N.A. Small molecular drug
High-throughput Screening Result Testing Cell Line: SF-539
Zero Interaction Potency (ZIP) Score: 2.76
Bliss Independence Score: 2.72
Loewe Additivity Score: 1.64
LHighest Single Agent (HSA) Score: 4.33

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of BIO-300
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
Rheumatoid arthritis FA20 Phase 1 [3]
Indication(s) of Aminolevulinic Acid Hydrochloride
Disease Entry ICD 11 Status REF
Actinic keratosis EK90.0 Approved [4]
Aminolevulinic Acid Hydrochloride Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Protoporphyrinogen oxidase (PPOX) TTNFMS9 PPOX_HUMAN Modulator [5]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Adult T acute lymphoblastic leukemia DCHZZYB MOLT-4 Investigative [1]
Anaplastic large cell lymphoma DCQTOKG SR Investigative [1]
Clear cell renal cell carcinoma DCJ01D6 A498 Investigative [1]
Papillary renal cell carcinoma DC2TAQD ACHN Investigative [1]
Colon adenocarcinoma DCPOU65 COLO 205 Investigative [6]
Invasive ductal carcinoma DCLX5S7 T-47D Investigative [6]
Adenocarcinoma DCHZ7S5 OVCAR3 Investigative [7]
Large cell lung carcinoma DCARRH9 NCI-H460 Investigative [7]
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⏷ Show the Full List of 8 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of Humanetics.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.
6 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
7 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.