DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
Serine/threonine-protein kinase Chk1 (CHEK1)
|
OTTTI622
|
CHK1_HUMAN
|
Increases Phosphorylation
|
[9] |
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)
|
OTA1CPBV
|
TR10B_HUMAN
|
Increases Expression
|
[9] |
Baculoviral IAP repeat-containing protein 5 (BIRC5)
|
OTILXZYL
|
BIRC5_HUMAN
|
Decreases Expression
|
[9] |
Cellular tumor antigen p53 (TP53)
|
OTIE1VH3
|
P53_HUMAN
|
Increases Phosphorylation
|
[9] |
Poly polymerase 1 (PARP1)
|
OT310QSG
|
PARP1_HUMAN
|
Decreases Activity
|
[10] |
Apoptosis regulator Bcl-2 (BCL2)
|
OT9DVHC0
|
BCL2_HUMAN
|
Decreases Expression
|
[9] |
Proliferating cell nuclear antigen (PCNA)
|
OTHZ1RIA
|
PCNA_HUMAN
|
Decreases Expression
|
[11] |
Histone H2AX (H2AX)
|
OT18UX57
|
H2AX_HUMAN
|
Increases Expression
|
[11] |
DNA damage-inducible transcript 3 protein (DDIT3)
|
OTI8YKKE
|
DDIT3_HUMAN
|
Increases Expression
|
[9] |
Cyclin-dependent kinase inhibitor 1 (CDKN1A)
|
OTQWHCZE
|
CDN1A_HUMAN
|
Increases Expression
|
[11] |
Proliferation marker protein Ki-67 (MKI67)
|
OTA8N1QI
|
KI67_HUMAN
|
Decreases Expression
|
[11] |
Apoptosis regulator BAX (BAX)
|
OTAW0V4V
|
BAX_HUMAN
|
Increases Expression
|
[11] |
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)
|
OTAYZMOY
|
SIR1_HUMAN
|
Increases Expression
|
[12] |
Bromodomain-containing protein 4 (BRD4)
|
OT2Y2TCW
|
BRD4_HUMAN
|
Affects Response To Substance
|
[11] |
Breast cancer type 1 susceptibility protein (BRCA1)
|
OT5BN6VH
|
BRCA1_HUMAN
|
Affects Response To Substance
|
[13] |
DNA mismatch repair protein Msh3 (MSH3)
|
OTD3YPVL
|
MSH3_HUMAN
|
Decreases Response To Substance
|
[14] |
Fumarate hydratase, mitochondrial (FH)
|
OTEQWU6Q
|
FUMH_HUMAN
|
Increases Response To Substance
|
[15] |
Breast cancer type 2 susceptibility protein (BRCA2)
|
OTF1XSV1
|
BRCA2_HUMAN
|
Affects Response To Substance
|
[13] |
Succinate dehydrogenase iron-sulfur subunit, mitochondrial (SDHB)
|
OTRE1M1T
|
SDHB_HUMAN
|
Increases Response To Substance
|
[15] |
Ubiquitin carboxyl-terminal hydrolase BAP1 (BAP1)
|
OTS8G0EN
|
BAP1_HUMAN
|
Increases Response To Substance
|
[16] |
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