Details of the Drug Combination

General Information of Drug Combination (ID: DCRHE85)

Drug Combination Name
Indazole derivative 5 TEM
Indication
Disease Entry Status REF
Melanoma Investigative [1]
Component Drugs Indazole derivative 5   DMM1I8R TEM   DMLNFWU
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: SK-MEL-2
Zero Interaction Potency (ZIP) Score: 2.28
Bliss Independence Score: 4.58
Loewe Additivity Score: 2.92
LHighest Single Agent (HSA) Score: 3.15

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indazole derivative 5 Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
ABL T315I mutant (ABL T315I) TTZJTWA ABL1_HUMAN Inhibitor [3]
Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I) TTIV39N BCR_HUMAN-ABL1_HUMAN Inhibitor [3]
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Indication(s) of TEM
Disease Entry ICD 11 Status REF
Postherpetic neuralgia 1E91.5 Phase 2 [2]

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Plasma cell myeloma DCVVLQT RPMI-8226 Investigative [4]
Colon adenocarcinoma DCJ9UAA COLO 205 Investigative [5]
Invasive ductal carcinoma DCXPTRU T-47D Investigative [5]
Invasive ductal carcinoma DCNQZ7E BT-549 Investigative [5]
Adenocarcinoma DCV19MO DU-145 Investigative [1]
Adenocarcinoma DCCB258 HT29 Investigative [1]
Amelanotic melanoma DC7I5VT M14 Investigative [1]
High grade ovarian serous adenocarcinoma DCIJ9XK OVCAR-8 Investigative [1]
High grade ovarian serous adenocarcinoma DC39CXQ NCI\\/ADR-RES Investigative [1]
Lung adenocarcinoma DCLANZG HOP-62 Investigative [1]
Melanoma DCE56V4 UACC-257 Investigative [1]
Ovarian serous cystadenocarcinoma DCVFD3V SK-OV-3 Investigative [1]
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⏷ Show the Full List of 12 DrugCom(s)

References

1 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800030055)
3 Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.