DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
Glycogen synthase kinase-3 beta (GSK3B)
|
OTL3L14B
|
GSK3B_HUMAN
|
Increases Phosphorylation
|
[8] |
Caspase-8 (CASP8)
|
OTA8TVI8
|
CASP8_HUMAN
|
Decreases Expression
|
[8] |
Nuclear factor erythroid 2-related factor 2 (NFE2L2)
|
OT0HENJ5
|
NF2L2_HUMAN
|
Increases Expression
|
[8] |
Muscarinic acetylcholine receptor M2 (CHRM2)
|
OTUMZ2WR
|
ACM2_HUMAN
|
Decreases Activity
|
[9] |
Muscarinic acetylcholine receptor M1 (CHRM1)
|
OTKW3E6B
|
ACM1_HUMAN
|
Decreases Activity
|
[9] |
D(2) dopamine receptor (DRD2)
|
OTBLXKEG
|
DRD2_HUMAN
|
Decreases Activity
|
[9] |
Alpha-2C adrenergic receptor (ADRA2C)
|
OT5B9RKP
|
ADA2C_HUMAN
|
Decreases Activity
|
[9] |
D(1A) dopamine receptor (DRD1)
|
OTLZPBT7
|
DRD1_HUMAN
|
Decreases Activity
|
[9] |
Substance-P receptor (TACR1)
|
OTCL9OC5
|
NK1R_HUMAN
|
Decreases Activity
|
[9] |
5-hydroxytryptamine receptor 2A (HTR2A)
|
OTWXJX0M
|
5HT2A_HUMAN
|
Decreases Activity
|
[9] |
5-hydroxytryptamine receptor 2C (HTR2C)
|
OT6H8DE0
|
5HT2C_HUMAN
|
Decreases Activity
|
[9] |
Histamine H1 receptor (HRH1)
|
OT8F9FV6
|
HRH1_HUMAN
|
Decreases Activity
|
[9] |
Alpha-1B adrenergic receptor (ADRA1B)
|
OTSAYAFD
|
ADA1B_HUMAN
|
Decreases Activity
|
[9] |
Mu-type opioid receptor (OPRM1)
|
OT16AAT8
|
OPRM_HUMAN
|
Decreases Activity
|
[9] |
Vasopressin V1a receptor (AVPR1A)
|
OTKR8AFL
|
V1AR_HUMAN
|
Decreases Activity
|
[9] |
Kappa-type opioid receptor (OPRK1)
|
OTXCZF4L
|
OPRK_HUMAN
|
Decreases Activity
|
[9] |
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)
|
OTOA8WU2
|
PDE4B_HUMAN
|
Decreases Activity
|
[9] |
Voltage-dependent L-type calcium channel subunit alpha-1C (CACNA1C)
|
OT6KFNMS
|
CAC1C_HUMAN
|
Decreases Activity
|
[9] |
Aurora kinase B (AURKB)
|
OTIY4VHU
|
AURKB_HUMAN
|
Decreases Activity
|
[9] |
NF-kappa-B inhibitor epsilon (NFKBIE)
|
OTLAYEL9
|
IKBE_HUMAN
|
Increases Expression
|
[6] |
Transcription factor MafG (MAFG)
|
OTBQFUZH
|
MAFG_HUMAN
|
Decreases Expression
|
[6] |
SH3 domain-binding protein 5 (SH3BP5)
|
OTOOEGUJ
|
3BP5_HUMAN
|
Affects Expression
|
[10] |
Dynamin-like 120 kDa protein, mitochondrial (OPA1)
|
OTJGNWPW
|
OPA1_HUMAN
|
Increases Cleavage
|
[11] |
Mitofusin-2 (MFN2)
|
OTPYN8A3
|
MFN2_HUMAN
|
Decreases Expression
|
[11] |
Urokinase-type plasminogen activator (PLAU)
|
OTX0QGKK
|
UROK_HUMAN
|
Increases Expression
|
[6] |
Platelet-derived growth factor subunit B (PDGFB)
|
OTMFMFC3
|
PDGFB_HUMAN
|
Increases Expression
|
[6] |
Annexin A1 (ANXA1)
|
OT5OFDJC
|
ANXA1_HUMAN
|
Affects Expression
|
[10] |
Endothelin-1 (EDN1)
|
OTZCACEG
|
EDN1_HUMAN
|
Increases Expression
|
[6] |
Amino acid transporter heavy chain SLC3A2 (SLC3A2)
|
OTBR33M9
|
4F2_HUMAN
|
Decreases Expression
|
[6] |
ATP-dependent 6-phosphofructokinase, muscle type (PFKM)
|
OT1QY9JM
|
PFKAM_HUMAN
|
Decreases Expression
|
[11] |
Glutathione S-transferase A1 (GSTA1)
|
OTA7K5XA
|
GSTA1_HUMAN
|
Decreases Expression
|
[10] |
Glutathione S-transferase P (GSTP1)
|
OTLP0A0Y
|
GSTP1_HUMAN
|
Increases Expression
|
[10] |
Growth-regulated alpha protein (CXCL1)
|
OT3WCTZV
|
GROA_HUMAN
|
Increases Expression
|
[6] |
Heme oxygenase 1 (HMOX1)
|
OTC1W6UX
|
HMOX1_HUMAN
|
Decreases Expression
|
[6] |
Poly polymerase 1 (PARP1)
|
OT310QSG
|
PARP1_HUMAN
|
Increases Cleavage
|
[12] |
Retinoic acid receptor alpha (RARA)
|
OT192V9V
|
RARA_HUMAN
|
Affects Expression
|
[10] |
Endoplasmic reticulum chaperone BiP (HSPA5)
|
OTFUIRAO
|
BIP_HUMAN
|
Increases Expression
|
[6] |
C-C motif chemokine 2 (CCL2)
|
OTAD2HEL
|
CCL2_HUMAN
|
Increases Expression
|
[6] |
Pyruvate kinase PKM (PKM)
|
OTLHHMC2
|
KPYM_HUMAN
|
Decreases Expression
|
[11] |
Interleukin-1 receptor type 1 (IL1R1)
|
OTTU8959
|
IL1R1_HUMAN
|
Affects Expression
|
[10] |
Beta-1,4-galactosyltransferase 1 (B4GALT1)
|
OTBCXEK7
|
B4GT1_HUMAN
|
Increases Expression
|
[6] |
NAD(P)H dehydrogenase 1 (NQO1)
|
OTZGGIVK
|
NQO1_HUMAN
|
Decreases Expression
|
[6] |
Glutathione peroxidase 2 (GPX2)
|
OTXI2NTI
|
GPX2_HUMAN
|
Affects Expression
|
[10] |
C-X-C motif chemokine 2 (CXCL2)
|
OTEJCYMY
|
CXCL2_HUMAN
|
Increases Expression
|
[6] |
Tumor necrosis factor alpha-induced protein 3 (TNFAIP3)
|
OTVLI4DD
|
TNAP3_HUMAN
|
Increases Expression
|
[6] |
Ribosomal protein S6 kinase beta-1 (RPS6KB1)
|
OTAELNGX
|
KS6B1_HUMAN
|
Decreases Phosphorylation
|
[11] |
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)
|
OTDRV63V
|
GA45A_HUMAN
|
Affects Expression
|
[10] |
DnaJ homolog subfamily B member 1 (DNAJB1)
|
OTCOSEVH
|
DNJB1_HUMAN
|
Affects Expression
|
[10] |
DNA damage-inducible transcript 3 protein (DDIT3)
|
OTI8YKKE
|
DDIT3_HUMAN
|
Increases Expression
|
[6] |
Lon protease homolog, mitochondrial (LONP1)
|
OT665WYT
|
LONM_HUMAN
|
Decreases Expression
|
[13] |
Signal transducer and activator of transcription 3 (STAT3)
|
OTAAGKYZ
|
STAT3_HUMAN
|
Decreases Phosphorylation
|
[12] |
Serine/threonine-protein kinase mTOR (MTOR)
|
OTHH8KU7
|
MTOR_HUMAN
|
Decreases Phosphorylation
|
[11] |
Glutamate--cysteine ligase catalytic subunit (GCLC)
|
OTESDI4D
|
GSH1_HUMAN
|
Decreases Expression
|
[6] |
Glutamate--cysteine ligase regulatory subunit (GCLM)
|
OT6CP234
|
GSH0_HUMAN
|
Decreases Expression
|
[6] |
Fatty acid synthase (FASN)
|
OTFII9KG
|
FAS_HUMAN
|
Decreases Expression
|
[14] |
Small ribosomal subunit protein eS6 (RPS6)
|
OTT4D1LN
|
RS6_HUMAN
|
Decreases Expression
|
[11] |
Oxidized low-density lipoprotein receptor 1 (OLR1)
|
OTS44RIC
|
OLR1_HUMAN
|
Increases Expression
|
[6] |
C-C motif chemokine 20 (CCL20)
|
OTUCJY4N
|
CCL20_HUMAN
|
Increases Expression
|
[6] |
Heat shock factor protein 1 (HSF1)
|
OTYNJ4KP
|
HSF1_HUMAN
|
Increases Activity
|
[15] |
Antigen peptide transporter 1 (TAP1)
|
OTJL27PW
|
TAP1_HUMAN
|
Increases Expression
|
[6] |
Tumor necrosis factor receptor superfamily member 9 (TNFRSF9)
|
OTNOM26L
|
TNR9_HUMAN
|
Increases Expression
|
[6] |
Baculoviral IAP repeat-containing protein 3 (BIRC3)
|
OT3E95KB
|
BIRC3_HUMAN
|
Increases Expression
|
[6] |
Sequestosome-1 (SQSTM1)
|
OTGY5D5J
|
SQSTM_HUMAN
|
Decreases Expression
|
[6] |
Kelch-like ECH-associated protein 1 (KEAP1)
|
OTFHOD0C
|
KEAP1_HUMAN
|
Decreases Expression
|
[6] |
Neutral amino acid transporter B(0) (SLC1A5)
|
OTE2H26Q
|
AAAT_HUMAN
|
Decreases Expression
|
[11] |
Mitofusin-1 (MFN1)
|
OTCBXQZF
|
MFN1_HUMAN
|
Decreases Expression
|
[11] |
Scavenger receptor class B member 1 (SCARB1)
|
OTAE1UA1
|
SCRB1_HUMAN
|
Affects Expression
|
[10] |
Thyroid hormone-inducible hepatic protein (THRSP)
|
OTKYE01L
|
THRSP_HUMAN
|
Decreases Expression
|
[14] |
Multidrug and toxin extrusion protein 1 (SLC47A1)
|
OTZX0U5Q
|
S47A1_HUMAN
|
Increases Expression
|
[16] |
Bcl-2-binding component 3, isoforms 3/4 (BBC3)
|
OTUAXDAY
|
BBC3B_HUMAN
|
Increases Expression
|
[6] |
Tribbles homolog 3 (TRIB3)
|
OTG5OS7X
|
TRIB3_HUMAN
|
Decreases Expression
|
[6] |
Sigma non-opioid intracellular receptor 1 (SIGMAR1)
|
OTDORW5C
|
SGMR1_HUMAN
|
Decreases Expression
|
[13] |
Sulfiredoxin-1 (SRXN1)
|
OTYDBO4L
|
SRXN1_HUMAN
|
Decreases Expression
|
[6] |
Prolyl hydroxylase EGLN3 (EGLN3)
|
OTXV3RYX
|
EGLN3_HUMAN
|
Affects Expression
|
[10] |
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)
|
OTHTAM54
|
AAKG2_HUMAN
|
Affects Expression
|
[6] |
------------------------------------------------------------------------------------ |
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