Details of the Drug Combination

General Information of Drug Combination (ID: DCUQWIC)

Drug Combination Name
SY-1425 Terameprocol
Indication
Disease Entry Status REF
Childhood T acute lymphoblastic leukemia Investigative [1]
Component Drugs SY-1425   DMH8UF0 Terameprocol   DMC3P45
N.A. Small molecular drug
High-throughput Screening Result Testing Cell Line: CCRF-CEM
Zero Interaction Potency (ZIP) Score: 0.96
Bliss Independence Score: 6.84
Loewe Additivity Score: 3.28
LHighest Single Agent (HSA) Score: 5.03

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of SY-1425
Disease Entry ICD 11 Status REF
Acute myeloid leukaemia 2A60 Phase 1 [2]
Myelodysplastic syndrome 2A37 Phase 1 [2]
SY-1425 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Retinoic acid receptor alpha (RARA) TTW38KT RARA_HUMAN Agonist [2]
------------------------------------------------------------------------------------
Indication(s) of Terameprocol
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 2 [3]
Terameprocol Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Transcription factor Sp1 (SP1) TTZEP6S SP1_HUMAN Modulator [3]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Astrocytoma DCUU5KG SNB-19 Investigative [1]
Chronic myelogenous leukemia DCHTK01 K-562 Investigative [1]
Glioma DCWDG2S SF-295 Investigative [1]
Papillary renal cell carcinoma DC3O9QK ACHN Investigative [1]
Renal cell carcinoma DCI4FN3 UO-31 Investigative [1]
Invasive ductal carcinoma DCKS5JY T-47D Investigative [4]
Adenocarcinoma DCSN8T0 NCIH23 Investigative [5]
Adenocarcinoma DCE49JO HCT116 Investigative [5]
Adenocarcinoma DCAYAR2 HCT-15 Investigative [5]
Adenocarcinoma DC9OIZJ SW-620 Investigative [5]
Cutaneous melanoma DCK9XX9 SK-MEL-28 Investigative [5]
Large cell lung carcinoma DCSFEFK NCI-H460 Investigative [5]
Mixed endometrioid and clear cell carcinoma DC9AKQ7 IGROV1 Investigative [5]
Non-small cell lung carcinoma DCTGDSH HOP-92 Investigative [5]
Prostate carcinoma DCN4GSL PC-3 Investigative [5]
------------------------------------------------------------------------------------
⏷ Show the Full List of 15 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3 Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. IDrugs. 2008 Mar;11(3):204-14.
4 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
5 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.