Details of the Drug Combination

General Information of Drug Combination (ID: DCVHWRA)

Drug Combination Name
BIO-300 Taxol
Indication
Disease Entry Status REF
Clear cell renal cell carcinoma Investigative [1]
Component Drugs BIO-300   DMJ7NVI Taxol   DMUOT9V
N.A. Small molecular drug
High-throughput Screening Result Testing Cell Line: CAKI-1
Zero Interaction Potency (ZIP) Score: 0.05
Bliss Independence Score: 0.92
Loewe Additivity Score: 5.32
LHighest Single Agent (HSA) Score: 6.78

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of BIO-300
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
Rheumatoid arthritis FA20 Phase 1 [3]
Indication(s) of Taxol
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [4]
Solid tumour/cancer 2A00-2F9Z Approved [5]
Pancreatic cancer 2C10 Phase 3 [6]
Gastric adenocarcinoma 2B72 Phase 2 [3]
Ovarian cancer 2C73 Phase 2 [3]
Taxol Interacts with 2 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Apoptosis regulator Bcl-2 (BCL-2) TTJGNVC BCL2_HUMAN Modulator [4]
Tubulin beta (TUBB) TTYFKSZ NOUNIPROTAC Modulator [4]
------------------------------------------------------------------------------------

Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Chronic myelogenous leukemia DCL6C1X K-562 Investigative [1]
Glioma DCN4EVW SF-268 Investigative [1]
Colon adenocarcinoma DCV4AKS COLO 205 Investigative [7]
Adenocarcinoma DC8O7QJ NCIH23 Investigative [8]
Adenocarcinoma DCUNE2M HCT-15 Investigative [8]
Adenocarcinoma DCXZUCT SW-620 Investigative [8]
Cutaneous melanoma DCN4156 SK-MEL-28 Investigative [8]
Lung adenocarcinoma DC8B9L6 HOP-62 Investigative [8]
------------------------------------------------------------------------------------
⏷ Show the Full List of 8 DrugCom(s)

References

1 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
2 Clinical pipeline report, company report or official report of Humanetics.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res. 2009 Sep 1;69(17):6906-14.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
7 Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.
8 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.