DOT Name |
DOT ID |
UniProt ID |
Mode of Action |
REF |
Cytochrome P450 11B1, mitochondrial (CYP11B1)
|
OTKKL894
|
C11B1_HUMAN
|
Increases Expression
|
[6] |
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 (HSD3B2)
|
OT02MSKN
|
3BHS2_HUMAN
|
Decreases Expression
|
[6] |
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)
|
OT2NV3AN
|
CP11A_HUMAN
|
Decreases Expression
|
[7] |
Steroid 21-hydroxylase (CYP21A2)
|
OTN0UDVP
|
CP21A_HUMAN
|
Decreases Expression
|
[7] |
Steroidogenic acute regulatory protein, mitochondrial (STAR)
|
OTFEZ5AI
|
STAR_HUMAN
|
Decreases Expression
|
[7] |
Prostaglandin G/H synthase 2 (PTGS2)
|
OT75U9M4
|
PGH2_HUMAN
|
Increases Expression
|
[8] |
Cytochrome P450 3A4 (CYP3A4)
|
OTQGYY83
|
CP3A4_HUMAN
|
Increases Expression
|
[9] |
Transforming growth factor beta-1 proprotein (TGFB1)
|
OTV5XHVH
|
TGFB1_HUMAN
|
Decreases Expression
|
[10] |
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)
|
OTZKVLVJ
|
CP17A_HUMAN
|
Decreases Expression
|
[10] |
cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A)
|
OT589JA2
|
KAP0_HUMAN
|
Decreases Expression
|
[10] |
Caspase-3 (CASP3)
|
OTIJRBE7
|
CASP3_HUMAN
|
Increases Activity
|
[10] |
Caspase-7 (CASP7)
|
OTAPJ040
|
CASP7_HUMAN
|
Increases Activity
|
[10] |
Cytochrome c oxidase subunit 2 (COX2)
|
OTTMVBJJ
|
COX2_HUMAN
|
Decreases Expression
|
[11] |
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial (COX4I1)
|
OTU0FC24
|
COX41_HUMAN
|
Decreases Expression
|
[11] |
Cytochrome P450 11B2, mitochondrial (CYP11B2)
|
OTIOLWYN
|
C11B2_HUMAN
|
Decreases Expression
|
[11] |
Stearoyl-CoA desaturase (SCD)
|
OTB1073G
|
SCD_HUMAN
|
Decreases Expression
|
[12] |
Nuclear receptor subfamily 1 group I member 2 (NR1I2)
|
OTC5U0N5
|
NR1I2_HUMAN
|
Increases Activity
|
[12] |
Estrogen receptor (ESR1)
|
OTKLU61J
|
ESR1_HUMAN
|
Increases Activity
|
[13] |
Sex hormone-binding globulin (SHBG)
|
OTPWU5IW
|
SHBG_HUMAN
|
Increases Expression
|
[14] |
Progesterone receptor (PGR)
|
OT0FZ3QE
|
PRGR_HUMAN
|
Affects Binding
|
[15] |
Glia-derived nexin (SERPINE2)
|
OTYF5340
|
GDN_HUMAN
|
Increases Expression
|
[16] |
ATP-dependent translocase ABCB1 (ABCB1)
|
OTEJROBO
|
MDR1_HUMAN
|
Increases Expression
|
[12] |
Corticosteroid-binding globulin (SERPINA6)
|
OTOIBEW7
|
CBG_HUMAN
|
Increases Expression
|
[14] |
Androgen receptor (AR)
|
OTUBKAZZ
|
ANDR_HUMAN
|
Affects Binding
|
[15] |
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)
|
OTNAZVKB
|
3BHS1_HUMAN
|
Decreases Expression
|
[16] |
Cyclic AMP-responsive element-binding protein 1 (CREB1)
|
OT1MDLA1
|
CREB1_HUMAN
|
Increases Activity
|
[17] |
ETS domain-containing protein Elk-1 (ELK1)
|
OTH9MXD6
|
ELK1_HUMAN
|
Increases Activity
|
[17] |
Cytochrome P450 2B6 (CYP2B6)
|
OTOYO4S7
|
CP2B6_HUMAN
|
Increases Expression
|
[12] |
Ribonucleoside-diphosphate reductase large subunit (RRM1)
|
OTXGQOR9
|
RIR1_HUMAN
|
Increases Expression
|
[18] |
Phosphoenolpyruvate carboxykinase, cytosolic (PCK1)
|
OTNWEJ5Y
|
PCKGC_HUMAN
|
Decreases Expression
|
[12] |
Glucose-6-phosphatase catalytic subunit 1 (G6PC1)
|
OTJ6FM9F
|
G6PC1_HUMAN
|
Decreases Expression
|
[12] |
Neurogenic locus notch homolog protein 1 (NOTCH1)
|
OTI1WADQ
|
NOTC1_HUMAN
|
Increases Activity
|
[17] |
Fatty acid synthase (FASN)
|
OTFII9KG
|
FAS_HUMAN
|
Decreases Expression
|
[12] |
Nuclear receptor subfamily 1 group I member 3 (NR1I3)
|
OTS3SGH7
|
NR1I3_HUMAN
|
Increases Activity
|
[19] |
Mitochondrial 10-formyltetrahydrofolate dehydrogenase (ALDH1L2)
|
OTCH86VF
|
AL1L2_HUMAN
|
Increases Expression
|
[16] |
Estrogen receptor beta (ESR2)
|
OTXNR2WQ
|
ESR2_HUMAN
|
Increases Activity
|
[13] |
Thyroid hormone-inducible hepatic protein (THRSP)
|
OTKYE01L
|
THRSP_HUMAN
|
Decreases Expression
|
[12] |
CREB-binding protein (CREBBP)
|
OTPA4QGM
|
CBP_HUMAN
|
Increases Activity
|
[20] |
Tribbles homolog 3 (TRIB3)
|
OTG5OS7X
|
TRIB3_HUMAN
|
Increases Expression
|
[16] |
Growth/differentiation factor 15 (GDF15)
|
OTWQN50N
|
GDF15_HUMAN
|
Increases Expression
|
[16] |
Interferon beta (IFNB1)
|
OTYQGUB5
|
IFNB_HUMAN
|
Increases Response To Substance
|
[21] |
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