Details of the Drug Combination

General Information of Drug Combination (ID: DCXANDV)

• Drug Combination Name: ABIRATERONE + Plicamycin
• Indication: Malignant melanoma; Status: Investigative [1]
• Component Drugs:
  ABIRATERONE (DM8V75C): Small molecular drug
  Plicamycin (DM7C8YV): Small molecular drug
• High-throughput Screening Result:
  Testing Cell Line: LOX IMVI
  Zero Interaction Potency (ZIP) Score: 24.77
  Bliss Independence Score: 26.27
  Loewe Additivity Score: 28.99
  LHighest Single Agent (HSA) Score: 30.36

Molecular Interaction Atlas of This Drug Combination

Indication(s) of ABIRATERONE

Disease Entry	ICD 11	Status	REF
Prostate cancer	2C82.0	Approved	[2]

ABIRATERONE Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Steroid 17-alpha-monooxygenase (S17AH)	TTRA5BZ	CP17A_HUMAN	Modulator	[6]

ABIRATERONE Interacts with 4 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Decreases Activity	[7]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[8]
Membrane cofactor protein (CD46)	OTQ8NWJD	MCP_HUMAN	Increases Expression	[9]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Response To Substance	[10]

Indication(s) of Plicamycin

Disease Entry	ICD 11	Status	REF
Hypercalcaemia	5B91.0	Approved	[3]
Testicular cancer	2C80	Approved	[3]
Solid tumour/cancer	2A00-2F9Z	Withdrawn from market	[4]
Lung cancer	2C25.0	Investigative	[5]
Ovarian cancer	2C73	Investigative	[5]

Plicamycin Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
RNA synthesis (hRNA synth)	TTX2AYW	NOUNIPROTAC	Modulator	[12]

Plicamycin Interacts with 16 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[13]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Decreases Expression	[14]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[14]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[14]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[15]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Activity	[15]
Epoxide hydrolase 1 (EPHX1)	OTBKWQER	HYEP_HUMAN	Decreases Expression	[16]
Transcription factor Sp1 (SP1)	OTISPT4X	SP1_HUMAN	Decreases Expression	[11]
Proto-oncogene tyrosine-protein kinase Src (SRC)	OTETYX40	SRC_HUMAN	Decreases Expression	[17]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Decreases Expression	[18]
Tyrosine-protein kinase receptor UFO (AXL)	OTKA2SUX	UFO_HUMAN	Decreases Expression	[19]
Transcription factor Sp3 (SP3)	OTYDQZ1T	SP3_HUMAN	Decreases Expression	[11]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[20]
Epidermal growth factor receptor kinase substrate 8 (EPS8)	OTZ6ES6V	EPS8_HUMAN	Decreases Expression	[17]
TNFAIP3-interacting protein 1 (TNIP1)	OTRAOTEW	TNIP1_HUMAN	Decreases Expression	[21]
Sphingomyelin phosphodiesterase 3 (SMPD3)	OTHQBETH	NSMA2_HUMAN	Decreases Expression	[22]

Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Adult acute myeloid leukemia	DCM3SEG	HL-60(TB)	Investigative	[23]
Adult T acute lymphoblastic leukemia	DCLRX99	MOLT-4	Investigative	[23]
Astrocytoma	DCSSNM4	U251	Investigative	[23]
Astrocytoma	DCW9DMG	SNB-19	Investigative	[23]
Childhood T acute lymphoblastic leukemia	DCG14QT	CCRF-CEM	Investigative	[23]
Chronic myelogenous leukemia	DCY8SRU	K-562	Investigative	[23]
Clear cell renal cell carcinoma	DCHM91D	786-0	Investigative	[23]
Clear cell renal cell carcinoma	DCM9G39	A498	Investigative	[23]
Clear cell renal cell carcinoma	DCX3VDW	TK-10	Investigative	[23]
Clear cell renal cell carcinoma	DC15MP5	CAKI-1	Investigative	[23]
Glioblastoma	DCK9BT7	SNB-75	Investigative	[23]
Glioma	DCWHA60	SF-295	Investigative	[23]
Glioma	DCUFL1V	SF-539	Investigative	[23]
Papillary renal cell carcinoma	DCC78EE	ACHN	Investigative	[23]
Plasma cell myeloma	DCEWB22	RPMI-8226	Investigative	[23]
Renal cell carcinoma	DC4YK5L	UO-31	Investigative	[23]
Renal cell carcinoma	DCUYOOI	SN12C	Investigative	[23]
Breast adenocarcinoma	DC3A52F	MDA-MB-468	Investigative	[24]
Carcinoma	DCC0NXQ	MCF7	Investigative	[24]
Colon adenocarcinoma	DC20TBS	COLO 205	Investigative	[24]
Colon carcinoma	DCJIWN6	KM12	Investigative	[24]
Invasive ductal carcinoma	DCBCYQ1	BT-549	Investigative	[24]
Invasive ductal carcinoma	DCKC3D6	T-47D	Investigative	[24]
Invasive ductal carcinoma	DCK3LOJ	HS 578T	Investigative	[24]
Adenocarcinoma	DCP4C65	DU-145	Investigative	[1]
Adenocarcinoma	DC08NY5	OVCAR3	Investigative	[1]
Adenocarcinoma	DCDKMVK	HCT116	Investigative	[1]
Amelanotic melanoma	DCKR6JF	M14	Investigative	[1]
Amelanotic melanoma	DCI5JL6	MDA-MB-435	Investigative	[1]
Cutaneous melanoma	DCXSE44	SK-MEL-28	Investigative	[1]
Cutaneous melanoma	DC8I3XG	SK-MEL-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCJ2GEH	OVCAR-8	Investigative	[1]
High grade ovarian serous adenocarcinoma	DC0TMU8	OVCAR-4	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCNIN8Z	OVCAR-5	Investigative	[1]
Large cell lung carcinoma	DC4ID0K	NCI-H460	Investigative	[1]
Lung adenocarcinoma	DCYA9D8	MDA-MB-231	Investigative	[1]
Lung adenocarcinoma	DC2QCZE	NCI-H522	Investigative	[1]
Malignant melanoma	DCO7KCZ	UACC62	Investigative	[1]
Melanoma	DCO8MWI	UACC-257	Investigative	[1]
Melanoma	DCTAERX	SK-MEL-2	Investigative	[1]
Minimally invasive lung adenocarcinoma	DC2TZ3Q	NCI-H322M	Investigative	[1]
Mixed endometrioid and clear cell carcinoma	DCOORA0	IGROV1	Investigative	[1]
Ovarian serous cystadenocarcinoma	DC088NU	SK-OV-3	Investigative	[1]

References

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