Details of the Drug Combination

General Information of Drug Combination (ID: DCY6ZZ4)

Drug Combination Name

MK-1775 cycloheximide

Indication

Disease Entry	Status	REF
Ewing sarcoma	Investigative	[1]

Component Drugs

MK-1775 DM3WDZ5

cycloheximide DMGDA3C

Small molecular drug

2D MOL

3D MOL

3D MOL is unavailable

High-throughput Screening Result

Testing Cell Line: TC-71

Zero Interaction Potency (ZIP) Score: 26.987

Bliss Independence Score: 26.419

Loewe Additivity Score: 0.883

LHighest Single Agent (HSA) Score: 2.902

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of MK-1775

Disease Entry	ICD 11	Status	REF
Ovarian cancer	2C73	Phase 2	[2]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

MK-1775 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Wee1-like protein kinase (WEE1)	TTJFOAL	WEE1_HUMAN	Inhibitor	[6]
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MK-1775 Interacts with 2 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Decreases Phosphorylation	[5]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Response To Substance	[5]
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Indication(s) of cycloheximide

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[4]

cycloheximide Interacts with 1 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[14]
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cycloheximide Interacts with 120 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[15]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[7]
ATP-binding cassette sub-family C member 5 (ABCC5)	OT34G4US	MRP5_HUMAN	Decreases Expression	[7]
Transforming acidic coiled-coil-containing protein 1 (TACC1)	OTGX20TE	TACC1_HUMAN	Increases Expression	[7]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Increases Expression	[7]
Receptor tyrosine-protein kinase erbB-2 (ERBB2)	OTOAUNCK	ERBB2_HUMAN	Decreases Expression	[7]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[7]
Cyclin-A2 (CCNA2)	OTPHHYZJ	CCNA2_HUMAN	Decreases Expression	[7]
Insulin-like growth factor-binding protein 4 (IGFBP4)	OT2HZRBD	IBP4_HUMAN	Increases Expression	[7]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Expression	[7]
CCN family member 3 (CCN3)	OTOW5YL4	CCN3_HUMAN	Increases Expression	[7]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Expression	[16]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Decreases Expression	[16]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Activity	[17]
Dynamin-1-like protein (DNM1L)	OTXK1Q1G	DNM1L_HUMAN	Increases Expression	[18]
Apoptotic protease-activating factor 1 (APAF1)	OTJWIVY0	APAF_HUMAN	Decreases Expression	[18]
Glycosylphosphatidylinositol anchor attachment 1 protein (GPAA1)	OTWVRR35	GPAA1_HUMAN	Increases Expression	[18]
Interleukin-1 alpha (IL1A)	OTPSGILV	IL1A_HUMAN	Increases Expression	[18]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Increases Expression	[18]
Eukaryotic translation initiation factor 2 subunit 1 (EIF2S1)	OTM0GDTP	IF2A_HUMAN	Increases Expression	[18]
Protein kinase C beta type (PRKCB)	OTYQ0656	KPCB_HUMAN	Decreases Expression	[18]
Glia-derived nexin (SERPINE2)	OTYF5340	GDN_HUMAN	Increases Expression	[18]
ETS domain-containing protein Elk-1 (ELK1)	OTH9MXD6	ELK1_HUMAN	Increases Expression	[18]
Pleiotrophin (PTN)	OTYC7M2A	PTN_HUMAN	Increases Expression	[18]
CCN family member 2 (CCN2)	OTC39NSU	CCN2_HUMAN	Increases Expression	[18]
Kappa-type opioid receptor (OPRK1)	OTXCZF4L	OPRK_HUMAN	Increases Expression	[18]
Collagenase 3 (MMP13)	OTY8BZIE	MMP13_HUMAN	Increases Expression	[18]
Heterogeneous nuclear ribonucleoprotein H2 (HNRNPH2)	OTMGP4J7	HNRH2_HUMAN	Increases Expression	[18]
Single-stranded DNA-binding protein, mitochondrial (SSBP1)	OTH2PZWH	SSBP_HUMAN	Increases Expression	[18]
Oxysterols receptor LXR-alpha (NR1H3)	OT54YZ9I	NR1H3_HUMAN	Increases Expression	[18]
Mitogen-activated protein kinase 7 (MAPK7)	OTF7H7L7	MK07_HUMAN	Increases Expression	[18]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Increases Expression	[18]
SERTA domain-containing protein 2 (SERTAD2)	OTYIG6TP	SRTD2_HUMAN	Increases Expression	[18]
Next to BRCA1 gene 1 protein (NBR1)	OTVRL7J9	NBR1_HUMAN	Increases Expression	[18]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Increases Expression	[18]
5'-3' exonuclease PLD3 (PLD3)	OTL07SP2	PLD3_HUMAN	Increases Expression	[18]
Synaptopodin (SYNPO)	OTICDJAB	SYNPO_HUMAN	Increases Expression	[18]
Transmembrane protein 263 (TMEM263)	OTO1RSTS	TM263_HUMAN	Increases Expression	[18]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Increases Expression	[18]
Sororin (CDCA5)	OTZLCQ5U	CDCA5_HUMAN	Increases Expression	[18]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Increases Expression	[18]
Solute carrier family 22 member 4 (SLC22A4)	OT4LOVI9	S22A4_HUMAN	Increases Expression	[18]
CDC42 small effector protein 2 (CDC42SE2)	OT8SG9I1	C42S2_HUMAN	Increases Expression	[18]
Myotubularin-related protein 7 (MTMR7)	OT47NVYM	MTMR7_HUMAN	Increases Expression	[18]
Small ribosomal subunit protein uS7m (MRPS7)	OT57AX7G	RT07_HUMAN	Decreases Expression	[18]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Decreases Expression	[19]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Decreases Expression	[20]
Amino acid transporter heavy chain SLC3A2 (SLC3A2)	OTBR33M9	4F2_HUMAN	Increases Expression	[21]
NADPH--cytochrome P450 reductase (POR)	OTVIDOCH	NCPR_HUMAN	Decreases Expression	[22]
Tumor protein p53-inducible protein 11 (TP53I11)	OTFPDYZU	P5I11_HUMAN	Decreases Expression	[23]
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B)	OTA1CPBV	TR10B_HUMAN	Increases Expression	[24]
Transcription regulator protein BACH1 (BACH1)	OTY8004K	BACH1_HUMAN	Decreases Expression	[25]
Proepiregulin (EREG)	OTRM4NQY	EREG_HUMAN	Increases Expression	[26]
CASP8 and FADD-like apoptosis regulator (CFLAR)	OTX14BAS	CFLAR_HUMAN	Decreases Expression	[27]
Autophagy-related protein 13 (ATG13)	OTYMHNEJ	ATG13_HUMAN	Decreases Expression	[10]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Decreases Expression	[28]
Mitochondrial uncoupling protein 4 (SLC25A27)	OTSBOPGD	UCP4_HUMAN	Increases Expression	[29]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Expression	[26]
Protein c-Fos (FOS)	OTJBUVWS	FOS_HUMAN	Increases Expression	[30]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Decreases Expression	[31]
Protransforming growth factor alpha (TGFA)	OTPD1LL9	TGFA_HUMAN	Increases Expression	[26]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Activity	[32]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[33]
Superoxide dismutase , mitochondrial (SOD2)	OTIWXGZ9	SODM_HUMAN	Increases Expression	[34]
Cytochrome P450 2E1 (CYP2E1)	OTHQ17JG	CP2E1_HUMAN	Increases Degradation	[35]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[36]
Intercellular adhesion molecule 1 (ICAM1)	OTTOIX77	ICAM1_HUMAN	Decreases Expression	[37]
Transcription factor AP-2-alpha (TFAP2A)	OTMYT3NK	AP2A_HUMAN	Decreases Stability	[38]
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Increases Expression	[39]
Rho-related GTP-binding protein RhoC (RHOC)	OTOLE1FT	RHOC_HUMAN	Decreases Expression	[40]
Poly polymerase 1 (PARP1)	OT310QSG	PARP1_HUMAN	Increases Cleavage	[41]
Intestinal-type alkaline phosphatase (ALPI)	OTTQ468O	PPBI_HUMAN	Decreases Activity	[42]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[36]
E3 SUMO-protein ligase EGR2 (EGR2)	OTAVQ78J	EGR2_HUMAN	Increases Expression	[43]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Decreases Expression	[44]
C-C motif chemokine 2 (CCL2)	OTAD2HEL	CCL2_HUMAN	Increases Expression	[36]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[36]
Nuclear factor NF-kappa-B p105 subunit (NFKB1)	OTNRRD8I	NFKB1_HUMAN	Increases Expression	[36]
Receptor tyrosine-protein kinase erbB-3 (ERBB3)	OTRSST0A	ERBB3_HUMAN	Decreases Expression	[26]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Decreases Expression	[34]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Increases Phosphorylation	[45]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Increases Phosphorylation	[45]
Retinoblastoma-like protein 1 (RBL1)	OTDEBFYC	RBL1_HUMAN	Decreases Expression	[46]
Protein PML (PML)	OT6SM2GD	PML_HUMAN	Decreases Degradation	[47]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[48]
Pro-adrenomedullin (ADM)	OT7T0TA4	ADML_HUMAN	Increases Expression	[49]
Receptor-type tyrosine-protein kinase FLT3 (FLT3)	OTMSRYMK	FLT3_HUMAN	Decreases Expression	[50]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Decreases Expression	[51]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[52]
Cyclin-dependent kinase inhibitor 2A (CDKN2A)	OTN0ZWAE	CDN2A_HUMAN	Increases Expression	[53]
E3 ubiquitin-protein ligase RNF4 (RNF4)	OTCMXQRE	RNF4_HUMAN	Decreases Expression	[54]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Decreases Stability	[55]
Heat shock factor protein 1 (HSF1)	OTYNJ4KP	HSF1_HUMAN	Decreases Activity	[56]
Urokinase plasminogen activator surface receptor (PLAUR)	OTIRKKEQ	UPAR_HUMAN	Increases Expression	[57]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Affects Localization	[58]
Recombining binding protein suppressor of hairless (RBPJ)	OTD7CUG0	SUH_HUMAN	Decreases Expression	[59]
Tight junction protein ZO-1 (TJP1)	OTBDCUPK	ZO1_HUMAN	Decreases Expression	[37]
Bcl-2-like protein 1 (BCL2L1)	OTRC5K9O	B2CL1_HUMAN	Increases Expression	[60]
Induced myeloid leukemia cell differentiation protein Mcl-1 (MCL1)	OT2YYI1A	MCL1_HUMAN	Decreases Expression	[61]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Decreases Expression	[62]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Decreases Expression	[63]
Caspase-8 (CASP8)	OTA8TVI8	CASP8_HUMAN	Increases Activity	[64]
Nuclear factor erythroid 2-related factor 2 (NFE2L2)	OT0HENJ5	NF2L2_HUMAN	Decreases Expression	[65]
Hypoxia-inducible factor 1-alpha (HIF1A)	OTADSC03	HIF1A_HUMAN	Increases Degradation	[12]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Decreases Expression	[66]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Activity	[67]
Sodium/iodide cotransporter (SLC5A5)	OTU7E9G7	SC5A5_HUMAN	Increases Expression	[68]
Transcription termination factor 3, mitochondrial (MTERF3)	OTVE8W7X	MTEF3_HUMAN	Decreases Expression	[69]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1)	OTAYZMOY	SIR1_HUMAN	Decreases Expression	[70]
Proheparin-binding EGF-like growth factor (HBEGF)	OTLU00JS	HBEGF_HUMAN	Increases Expression	[26]
Endothelial PAS domain-containing protein 1 (EPAS1)	OTRE3O8U	EPAS1_HUMAN	Decreases Expression	[71]
Repressor of RNA polymerase III transcription MAF1 homolog (MAF1)	OTKB0N8Q	MAF1_HUMAN	Increases Degradation	[72]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Increases Response To Substance	[73]
MAP kinase-activated protein kinase 3 (MAPKAPK3)	OT7IWJNI	MAPK3_HUMAN	Affects Response To Substance	[13]
D-ribitol-5-phosphate cytidylyltransferase (CRPPA)	OTC85K8Q	ISPD_HUMAN	Affects Response To Substance	[13]
Rab9 effector protein with kelch motifs (RABEPK)	OTCZSREH	RABEK_HUMAN	Affects Response To Substance	[13]
Kremen protein 1 (KREMEN1)	OTGJFSAC	KREM1_HUMAN	Affects Response To Substance	[13]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Response To Substance	[74]
Unconventional myosin-Id (MYO1D)	OTP2RGPN	MYO1D_HUMAN	Affects Response To Substance	[13]
Cation channel sperm-associated protein 4 (CATSPER4)	OTXJ4E8J	CTSR4_HUMAN	Affects Response To Substance	[13]
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⏷ Show the Full List of 120 DOT(s)

References

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44	ERR contributes to HDAC6-induced chemoresistance of osteosarcoma cells. Cell Biol Toxicol. 2023 Jun;39(3):813-825. doi: 10.1007/s10565-021-09651-8. Epub 2021 Sep 15.
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