Details of the Drug Combination

General Information of Drug Combination (ID: DCYCUV5)

Drug Combination Name

Indazole derivative 5 PMID28870136-Compound-43

Indication

Disease Entry	Status	REF
Cutaneous melanoma	Investigative	[1]

Component Drugs

Indazole derivative 5 DMM1I8R

PMID28870136-Compound-43 DMWGV8N

Small molecular drug

2D MOL

3D MOL

High-throughput Screening Result

Testing Cell Line: SK-MEL-28

Zero Interaction Potency (ZIP) Score: 5.12

Bliss Independence Score: 6.7

Loewe Additivity Score: 2.36

LHighest Single Agent (HSA) Score: 2.1

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indazole derivative 5 Interacts with 2 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
ABL T315I mutant (ABL T315I)	TTZJTWA	ABL1_HUMAN	Inhibitor	[2]
Fusion protein Bcr-Abl T315I mutant (Bcr-Abl T315I)	TTIV39N	BCR_HUMAN-ABL1_HUMAN	Inhibitor	[2]
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PMID28870136-Compound-43 Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Ecto-5'-nucleotidase (CD73)	TTK0O6Y	5NTD_HUMAN	Inhibitor	[3]
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Test Results of This Drug Combination in Other Disease Systems

Indication	DrugCom ID	Cell Line	Status	REF
Invasive ductal carcinoma	DCEM46Q	BT-549	Investigative	[4]
Adenocarcinoma	DC76XZC	DU-145	Investigative	[1]
Cutaneous melanoma	DC3TPS7	SK-MEL-5	Investigative	[1]
High grade ovarian serous adenocarcinoma	DCRREFN	OVCAR-8	Investigative	[1]
Melanoma	DC7HC64	SK-MEL-2	Investigative	[1]
Melanoma	DCJ5GXG	MALME-3M	Investigative	[1]
Non-small cell lung carcinoma	DCWW2IL	HOP-92	Investigative	[1]
Pleural epithelioid mesothelioma	DCSW4HB	NCI-H226	Investigative	[1]
Prostate carcinoma	DCYR31G	PC-3	Investigative	[1]
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⏷ Show the Full List of 9 DrugCom(s)

References

1	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
2	Bcr-Abl tyrosine kinase inhibitors: a patent review.Expert Opin Ther Pat. 2015 Apr;25(4):397-412.
3	Ectonucleotidase inhibitors: a patent review (2011-2016).Expert Opin Ther Pat. 2017 Dec;27(12):1291-1304.
4	Biologically active neutrophil chemokine pattern in tonsillitis.Clin Exp Immunol. 2004 Mar;135(3):511-8. doi: 10.1111/j.1365-2249.2003.02390.x.