Details of the Drug Combination

General Information of Drug Combination (ID: DCYXR41)

Drug Combination Name
Povidone-iodine Chlorhexidine
Indication
Disease Entry Status REF
Staphylococcus Aureus Phase 1 [1]
Component Drugs Povidone-iodine   DMD4XOS Chlorhexidine   DMQ9MVG
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Povidone-iodine
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [2]
Indication(s) of Chlorhexidine
Disease Entry ICD 11 Status REF
Bacterial infection 1A00-1C4Z Approved [3]
Gingivitis DA0B Approved [4]
Intracerebral hemorrhage N.A. Approved [4]
Chlorhexidine Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Bacterial Dihydropteroate synthetase (Bact folP) TT4ILYC DHPS_ECOLI Breaker [5]
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Chlorhexidine Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Acetylcholinesterase (ACHE) OT2H8HG6 ACES_HUMAN Decreases Activity [6]
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Test Results of This Drug Combination in Other Disease Systems

Indication DrugCom ID Cell Line Status REF
Contraception DC4CAAA N. A. Phase 1 [7]
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References

1 ClinicalTrials.gov (NCT03173053) S. Aureus Decolonization in HPN Patients.
2 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3 FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 019822.
4 Chlorhexidine FDA Label
5 The mechanism of action of chlorhexidine. FEMS Microbiol Lett. 1992 Dec 15;79(1-3):211-5.
6 Profiling the Tox21 Chemical Collection for Acetylcholinesterase Inhibition. Environ Health Perspect. 2021 Apr;129(4):47008. doi: 10.1289/EHP6993. Epub 2021 Apr 12.
7 ClinicalTrials.gov (NCT02391714) Nitrous Oxide for Pain Management of Intrauterine Device (IUD) Insertion