Details of the Drug Combination

General Information of Drug Combination (ID: DCZZUNW)

Drug Combination Name

Venofer Oxandrolone

Indication

Disease Entry	Status	REF
Functional Iron Deficiency	Phase 2	[1]

Component Drugs

Venofer DMTK2VI

Oxandrolone DMU9MYJ

N.A.

Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)

Indication(s) of Venofer

Disease Entry	ICD 11	Status	REF
Fatigue	MG22	Approved	[2]

Indication(s) of Oxandrolone

Disease Entry	ICD 11	Status	REF
Alcoholic hepatitis	DB94.1	Approved	[3]

Oxandrolone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Androgen receptor (AR)	TTS64P2	ANDR_HUMAN	Agonist	[4]
------------------------------------------------------------------------------------

Oxandrolone Interacts with 1 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Sex hormone-binding globulin (SHBG)	OTPWU5IW	SHBG_HUMAN	Decreases Expression	[5]
------------------------------------------------------------------------------------

References

1	ClinicalTrials.gov (NCT02047552) RCT of Goal-directed Iron Supplementation of Anemic, Critically Ill Trauma Patients, With and Without Oxandrolone
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7092).
4	The effect of oxandrolone treatment on human osteoblastic cells. J Burns Wounds. 2007 Mar 7;6:e4.
5	Low sex hormone-binding globulin and testosterone levels in association with erectile dysfunction among human immunodeficiency virus-infected men receiving testosterone and oxandrolone. J Sex Med. 2008 Jan;5(1):241-7. doi: 10.1111/j.1743-6109.2007.00634.x. Epub 2007 Oct 24.