Details of the Drug Combinations

General Information of This Drug (ID: DM0DTF7)

Drug Name

Zonisamide DM0DTF7

Synonyms

Exceglan; Excegram; Excegran; Tremode; Trerief; Zonegran; Zonisamida; Zonisamidum; Elan brand of zonisamide; Zonisamida [Spanish]; Zonisamide monosodium; Zonisamidum [Latin]; AD 810; PD 110843; SPR_2; AD-810; AD-810N; E-2090; Excegran (TN); PD-110843; Zonegran (TN); Zonegran, Zonisamide; Zonisamide (ZNS); Zonisamide (JAN/USAN/INN); Zonisamide [USAN:BAN:INN:JAN]; 1,2-Benzisoxazole-3-methanesulfonamide; 1,2-benzoxazol-3-ylmethanesulfonamide; 1-(1,2-Benzoxazol-3-Yl)methanesulfonamide; 1-(1,2-benzisoxazol-3-yl)methanesulfonamide; 3-(Sulfamoylmethyl)-1,2-benzisoxazole; 3-sulfamoylmethyl-1,2-benzisoxazole

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Approved	[1]
Alcohol use disorder	6C40.2	Approved	[1]
Bipolar disorder	6A60	Approved	[1]
Epilepsy	8A60-8A68	Approved	[2]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
NITD609 + Zonisamide	DCS6VIB	NITD609	Hepatoblastoma (Cell Line: HB3)	[3]
Proguanil + Zonisamide	DC65AF2	Proguanil	DD2 (Cell Line: DD2)	[4]
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3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Zonisamide + Lamotrigine	DCKOFPV	Lamotrigine	Epilepsy	[5]
Zonisamide + Zonisamide	DCBID3N	Zonisamide	Weight Gain	[6]
Zonisamide + Bupropion	DC2HOHA	Bupropion	Smoking Cessation	[7]
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References

1	Zonisamide FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7047).
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5	ClinicalTrials.gov (NCT04939675) Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation
6	ClinicalTrials.gov (NCT00363376) A Study of Zonisamide to Prevent Olanzapine-Associated Weight Gain
7	ClinicalTrials.gov (NCT04388319) Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes