Details of the Drug Combinations

General Information of This Drug (ID: DM0P729)

Drug Name

GSK461364 DM0P729

Synonyms

GSK461364; 929095-18-1; GSK-461364; 5-[6-[(4-Methyl-1-piperazinyl)methyl]-1h-benzimidazol-1-yl]-3-[(1r)-1-[2-(trifluoromethyl)phenyl]ethoxy]-2-thiophenecarboxamide; GSK 461364; UNII-8QO27TK6Q4; GSK-461364A; (R)-5-(6-((4-methylpiperazin-1-yl)methyl)-1H-benzo[d]imidazol-1-yl)-3-(1-(2-(trifluoromethyl)phenyl)ethoxy)thiophene-2-carboxamide; 8QO27TK6Q4; CHEMBL1908394; GSK461364A; ZHJGWYRLJUCMRT-QGZVFWFLSA-N; SCHEMBL310080; GTPL5684; C27H28F3N5O2S; CTK8B7590; CHEBI:91333; DTXSID60239197; MolPort-016-633-304; BCP01720; GSK 461364A

Indication

Disease Entry	ICD 11	Status	REF
Non-hodgkin lymphoma	2B33.5	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
------------------------------------------------------------------------------------

Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-263 + GSK461364	DC4FLDV	ABT-263	Ewing sarcoma (Cell Line: TC-71)	[2]
AXL-1717 + GSK461364	DC8YXDF	AXL-1717	Ewing sarcoma (Cell Line: TC-71)	[3]
GSK461364 + Ruxolitinib	DCD42HA	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[3]
GSK461364 + AT13387	DC8J6PD	AT13387	Ewing sarcoma (Cell Line: TC-71)	[3]
GSK461364 + Mitomycin	DC5ACO5	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[3]
Ispinesib + GSK461364	DCM1B1N	Ispinesib	Ewing sarcoma (Cell Line: TC-71)	[3]
Lenvatinib + GSK461364	DCQD4LB	Lenvatinib	Ewing sarcoma (Cell Line: TC-71)	[3]
Methotrexate + GSK461364	DCHHJMJ	Methotrexate	Ewing sarcoma (Cell Line: TC-71)	[3]
OSI-906 + GSK461364	DCD7Z44	OSI-906	Ewing sarcoma (Cell Line: TC-71)	[2]
------------------------------------------------------------------------------------


⏷ Show the Full List of 9 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5684).
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.