Details of the Drug Combinations

General Information of This Drug (ID: DM12WYV)

Drug Name

6-bromoindirubin-3-oxime DM12WYV

Synonyms

6-bromoindirubin-3'-oxime (BIO)

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
6-bromoindirubin-3-oxime + Idarubicin	DC06JV3	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
6-bromoindirubin-3-oxime + Ruxolitinib	DCK4B6R	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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References

1	Stable generation of serum- and feeder-free embryonic stem cell-derived mice with full germline-competency by using a GSK3 specific inhibitor. Genesis. 2009 Jun;47(6):414-22.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.