Details of the Drug Combinations

General Information of This Drug (ID: DM1WGUT)

Drug Name
Epothilone D   DM1WGUT
Synonyms
Epothilone D; Desoxyepothilone b; (-)-Desoxyepothilone B; 189453-10-9; KOS-862; 12,13-Desoxyepothilone B; KOS 862; UNII-T0358E0YUF; (-)-Epothilone D; NSC-703147; T0358E0YUF; CHEBI:29579; 12,13-Deoxyepothilone B; NSC 703147; Epo D; EPD; (4S,7R,8S,9S,16S,Z)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-((E)-1-(2-methylthiazol-4-yl)prop-1-en-2-yl)oxacyclohexadec-13-ene-2,6-dione; (4S,7R,8S,9S,13Z,16S)-4,8-dihydroxy-5,5,7,9,13-pentamethyl-16-[(E)-1-methyl-2-(2-methylthiazol-4-yl)vinyl]-1-oxacyclohexadec-13-ene-2,6-dione; dEpoB
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Discontinued in Phase 2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

14 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Epothilone D + Buparlisib DCJ7CSV Buparlisib Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + MK-1775 DC3XDB0 MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Eltanexor oral DCGY2GD Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Everolimus DCQ6GPB Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Exherin DCLNPHG Exherin Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + AT7519 DC2BJ9C AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + OSI-906 DC0QFDA OSI-906 Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + SNX-5422 DCH8XE9 SNX-5422 Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Idarubicin DCXWING Idarubicin Glioblastoma? (Cell Line: T98G) [2]
Epothilone D + Decitabine DCPV81K Decitabine Ewing sarcoma (Cell Line: TC-71) [2]
Epothilone D + Ruxolitinib DCW1ALH Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Epothilone D + Ruxolitinib DCXVLNU Ruxolitinib Hodgkin lymphoma (Cell Line: HDLM-2) [3]
Epothilone D + Ruxolitinib DCGNFTJ Ruxolitinib Hodgkin lymphoma (Cell Line: U-HO1) [3]
JQ1 + Epothilone D DCIIJA2 JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 14 DrugCom(s)

References

1 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800015773)
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.