Details of the Drug Combinations

General Information of This Drug (ID: DM1YAK6)

Drug Name
GDC0941   DM1YAK6
Synonyms
Pictilisib; GDC-0941; 957054-30-7; PICTILISIB; Pictrelisib; GDC 0941; 4-(2-(1H-Indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; 2-(1H-Indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine; UNII-ICY00EMP8P; ICY00EMP8P; Pictilisib (GDC-0941); CHEBI:65326; AK-40872; Thieno[3,2-d]pyrimidine, 2-(1H-indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)-; GD9; GDC-0941, GDC0941; 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Phase 2 [1]
Non-hodgkin lymphoma 2B33.5 Phase 2 [2]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-263 + GDC0941 DCR8Q33 ABT-263 Glioblastoma (Cell Line: JHH-136) [3]
CA4P + GDC0941 DCKIFTU CA4P Glioblastoma (Cell Line: JHH-136) [4]
Fenretinide + GDC0941 DC6VV5D Fenretinide Glioblastoma (Cell Line: JHH-136) [4]
GDC0941 + Trametinib DC0OGBX Trametinib Glioblastoma (Cell Line: JHH-136) [4]
GDC0941 + Panobinostat DCRJV14 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [4]
GDC0941 + GDC-0980/RG7422 DCX8G0T GDC-0980/RG7422 Glioblastoma (Cell Line: JHH-136) [4]
GDC0941 + Pelitinib DCI02WW Pelitinib Glioblastoma (Cell Line: JHH-136) [4]
GDC0941 + Obatoclax DCIAJWJ Obatoclax Glioblastoma (Cell Line: JHH-136) [4]
GDC0941 + Podofilox DCJAOK9 Podofilox Glioblastoma (Cell Line: JHH-136) [4]
Mebendazole + GDC0941 DCKO7P9 Mebendazole Glioblastoma (Cell Line: JHH-136) [4]
Topetecan + GDC0941 DCXXTWQ Topetecan Glioblastoma (Cell Line: JHH-136) [4]
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⏷ Show the Full List of 11 DrugCom(s)
3 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Fulvestrant + GDC0941 DC6KKOZ Fulvestrant Breast Cancer [5]
GDC0941 + Cotellic DC1SD8X Cotellic Solid Tumors [6]
GDC0941 + Letrozole DCQ50K6 Letrozole Breast Cancer [7]
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References

1 Phase II Randomized Preoperative Window-of-Opportunity Study of the PI3K Inhibitor Pictilisib Plus Anastrozole Compared With Anastrozole Alone in P... J Clin Oncol. 2016 Jun 10;34(17):1987-94.
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5682).
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 ClinicalTrials.gov (NCT01437566) Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant in Advanced or Metastatic Breast Cancer in Participants Resistant to Aromatase Inhibitor Therapy
6 ClinicalTrials.gov (NCT00996892) Safety, Tolerability and Pharmacokinetics of Cobimetinib in Combination With Pictilisib in Patients With Locally Advanced or Metastatic Solid Tumors
7 ClinicalTrials.gov (NCT00960960) A Study of PI3-Kinase Inhibitor GDC-0941 in Combination With Paclitaxel, With and Without Bevacizumab or Trastuzumab, and With Letrozole, in Participants With Locally Recurrent or Metastatic Breast Cancer