Details of the Drug Combinations

General Information of This Drug (ID: DM2B9E0)

Drug Name
AT13387   DM2B9E0
Synonyms AT-13387
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 1 [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

21 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
AT13387 + Artemether DCUXBVL Artemether Ewing sarcoma (Cell Line: TC-71) [2]
AT13387 + Panobinostat DCGH0SR Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
AT13387 + AT7519 DCZWL21 AT7519 Ewing sarcoma (Cell Line: TC-71) [2]
AT13387 + Idarubicin DC9ZPZR Idarubicin Glioblastoma? (Cell Line: T98G) [2]
AT13387 + Bardoxolone methyl DCC3EWI Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [2]
Bafilomycin A1 + AT13387 DC4U4DM Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + AT13387 DCG9QNG BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Erlotinib + AT13387 DC48IOQ Erlotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Evacetrapib + AT13387 DCXANF1 Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
GDC-0084 + AT13387 DC115GZ GDC-0084 Ewing sarcoma (Cell Line: TC-71) [2]
GSK461364 + AT13387 DC8J6PD GSK461364 Ewing sarcoma (Cell Line: TC-71) [2]
JQ1 + AT13387 DCWP5X7 JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
JQ1 + AT13387 DCXJIS9 JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
Mitomycin + AT13387 DCQ38N8 Mitomycin Ewing sarcoma (Cell Line: TC-71) [2]
Nintedanib + AT13387 DCXHPP2 Nintedanib Ewing sarcoma (Cell Line: TC-71) [2]
OSI-027 + AT13387 DC2BFMP OSI-027 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + AT13387 DC1Y2O6 OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
Pyrazinamide + AT13387 DCDBBKI Pyrazinamide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
SCH 727965 + AT13387 DCOULIA SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Withaferin A + AT13387 DC3AAJQ Withaferin A Ewing sarcoma (Cell Line: TC-71) [2]
Ym155 + AT13387 DCBNZPM Ym155 Ewing sarcoma (Cell Line: TC-71) [2]
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⏷ Show the Full List of 21 DrugCom(s)

References

1 Clinical pipeline report, company report or official report of Astex Pharmaceuticals.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.