Details of the Drug Combinations

General Information of This Drug (ID: DM2GHCR)

Drug Name

Rebamipide DM2GHCR

Synonyms

rebamipide; 90098-04-7; Mucosta; Proamipide; 111911-87-6; OPC-12759; Rebamipidum; Pramipide; Rebamipide [INN:JAN]; Rebamipidum [INN-Latin]; Rebamipida [INN-Spanish]; OPC 12759; CCRIS 3585; Rebamipide hydrate; 2-(4-Chlorobenzoylamino)-3-(1,2-dihydro-2-oxo-4-quinolyl)propionic acid; 139344-42-6; 2-[(4-chlorobenzoyl)amino]-3-(2-oxo-1H-quinolin-4-yl)propanoic acid; Mucosta hydrate; NCGC00095161-01; Proamipide hydrate; 2-(4-Chlorobenzamido)-3-[2(1H)-quinolinon-4-yl]propionic Acid

Indication

Disease Entry	ICD 11	Status	REF
Peptic ulcer	DA61	Phase 3	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rebamipide + Marizomib	DCIWGK8	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Rebamipide + Idarubicin	DCBZOVQ	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Rebamipide + Pantoprazole	DC73ZBE	Pantoprazole	Stomach Ulcer	[3]
Rebamipide + Esomeprazole	DC2K7X3	Esomeprazole	Dyspepsia	[4]
Rebamipide + Lansoprazole	DCXE3NQ	Lansoprazole	Gastroesophageal Reflux	[5]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 871).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT01167101) Is Rebamipide Effective on the Healing of Iatrogenic Gastric Ulcer After Endoscopic Mucosal Resection?
4	ClinicalTrials.gov (NCT02134405) Rebamipide in Combination With Esomeprazole in the Management of Asian Patients With Functional Dyspepsia
5	ClinicalTrials.gov (NCT02755753) A Study to Evaluate REbamiPide as an Adjuvant Regimen to Heal erosIve Reflux Esophagitis