Details of the Drug Combinations

General Information of This Drug (ID: DM3OMDV)

Drug Name

XL-888 DM3OMDV

Synonyms

SCHEMBL17313415; QC-9274

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
XL-888 + Panobinostat	DCKC8BB	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
XL-888 + Marizomib	DC5HTTC	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	ClinicalTrials.gov (NCT00796484) Safety Study of Pharmacokinetics of XL888 in Adults With Solid Tumors. U.S. National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.