Details of the Drug Combinations

General Information of This Drug (ID: DM3YG5P)

Drug Name
GYKI-52466   DM3YG5P
Synonyms
Gyki-52466; 102771-26-6; GYKI 52466; UNII-471V8NZ5X3; GYKI 52466 HCl; CHEMBL275006; CHEBI:79560; 471V8NZ5X3; 1-(p-Aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine hydrochloride; 4-(8-methyl-9h-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-5-yl)aniline; 4-(8-Methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)benzenamine; Benzenamine,4-(8-methyl-9H-1,3-dioxolo[4,5-h][2,3]benzodiazepin-5-yl)-; Benzenamine, 4-(8-methyl-9H-1,3-dioxolo(4,5-h)(2,3)benzodiazepin-5-yl)-; C17H15N3O2
Indication
Disease Entry ICD 11 Status REF
Alzheimer disease 8A20 Terminated [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

44 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + GYKI-52466 DCT69YD Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + GYKI-52466 DCD23RF Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + GYKI-52466 DC98M3M Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + GYKI-52466 DCUUZEP Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + GYKI-52466 DCDXJ10 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + GYKI-52466 DCO0GHC Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorzoxazone + GYKI-52466 DCE9XIG Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + GYKI-52466 DC3KW7H Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + GYKI-52466 DC87N9I Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Ribavirin-TP DCFULUK Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Pentostatin DCK20ZQ Pentostatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Gefitinib DCFJ6O5 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Dantrolene DCWVJSA Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Methotrexate DCSOB61 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Vinblastine DCMLWPB Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Pepstatin DC02QCK Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Metyrosine DCA6IVL Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Itraconazole DCZ0P4D Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Docetaxel DCA4GA9 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Pentamidine DCF4IL6 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Oseltamivir DC4S9K2 Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Idarubicin DC1AHAN Idarubicin Glioblastoma? (Cell Line: T98G) [2]
GYKI-52466 + Ethinyl estradiol DCQ8O8G Ethinyl estradiol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Clascoterone DC5TZCH Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Leflunomide DC6R9VW Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Acarbose DCTBTZV Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Brincidofovir DCHK3D5 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Mycophenolic acid DCVM7ZH Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Cisatracurium DCVHSMH Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Auranofin DCT1WFS Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Vorinostat DCCKHM1 Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Cerivastatin DCXAK2N Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + GYKI-52466 DCUM7JJ Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + GYKI-52466 DCJW6KW IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + GYKI-52466 DCOQH2X Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + GYKI-52466 DCL3H9K Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + GYKI-52466 DCUTA76 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + GYKI-52466 DCKTSJR Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + GYKI-52466 DC5LZLJ Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitrosoglutathione + GYKI-52466 DCRD3PQ Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + GYKI-52466 DCG5NGA Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + GYKI-52466 DCVAQWO Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolvaptan + GYKI-52466 DC5G9NN Tolvaptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triamterene + GYKI-52466 DCLTZJ0 Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 44 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4210).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.