General Information of This Drug (ID: DM4KI7O)

Drug Name
Zidovudine   DM4KI7O
Synonyms
zidovudine; Azidothymidine; 30516-87-1; 3'-Azido-3'-deoxythymidine; Retrovir; AZT; Zidovudinum; Compound S; Thymidine, 3'-azido-3'-deoxy-; ZIDOVUDINE [AZT]; zidovudin; BW A509U; Zidovudinum [Latin]; Zidovudina [Spanish]; BWA509U; DRG-0004; 3'-Azido-2',3'-Dideoxythymidine; ZDV; UNII-4B9XT59T7S; 3'-Deoxy-3'-azidothymidine; CCRIS 105; Aztec; BW-A509U; BW-A-509U; HSDB 6515; 3'-Azido-3'-deoxythymidine (AIDS); CHEMBL129; NSC 602670; BW-A 509U; MLS000028548; 4B9XT59T7S; AZT; Antiviral; Azidodeoxythymidine; ZVD; Zidovudin; Zidovudina; AZT Antiviral; AZT TRANSPLACENTAL CARCINOGENESIS STUDY; Antiviral AZT; Cpd S; Racemic Liposomal AZT; Zidovudine EP III; BWA 509U; K7 [P Ti2 W10 O40]; AZT & EPO; AZT & HPA; AZT & Lymphoblastoid Interferon; AZT & SST; AZT & rsT4; AZT & sCD4; AZT & srCD4; AZT (Antiviral); AZT+PRO 140; AZT, Antiviral; Apo-Zidovudine; BWA-509U; Intron A & AZT; Novo-Azt; Propolis+AZT; Retrovir (TN); Retrovir(TM); Retrovis (TN); Zidovudine+PRO 140; AZT & Colony-stimulating factor 2; AZT & Concanavalin A (ConA); AZT & GM-CSF; AZT & IFN-alpha; AZT & IL-1; AZT & IL-2; AZT & IL-6; AZT & Li & EPO; AZT & NP (from PHCA or HSA); AZT & PM-19; DS-4152 & AZT; Liposomal AZT-SN-1; Liposomal AZT-SN-3; PC-SOD+AZT;RIFN-beta seron & AZT; AZT & CD4(178)-PE 40; AZT & Li & GM-CSF; AZT & Li & IL-1; AZT & Li & IL-6; AZT & rIFNalpha2; Racemic-dipalmitoylglycerophospho-AZT (in a lipid vesicle); Zidovudine (JAN/USP/INN); Zidovudine [USAN:INN:BAN:JAN]; AZT & rsCD4 & rIFNalphaA; SN-1-dipalmitoylglycerophospho-AZT (in a lipid vesicle); SN-3-dipalmitoylglycerophospho-AZT (in a lipid vesicle); AZT & Interferon-alpha-2; Met-SDF-1beta & AZT; Met-SDF-1beta & Zidovudine; Interferon AD + 3'-azido-3'-deoxythymidine; 1-(3-Azido-2,3-dideoxy-beta-D-ribofuranosyl)thymine; 3′-Azido-3′-deoxythymidine; 3' Azido 2',3' Dideoxythymidine; 3' Azido 3' deoxythymidine; 3'-Azido-3'-deoxythymidine & Concanavalin A; 3'-Azido-3'-deoxythymidine & Erythropoietin; 3'-Azido-3'-deoxythymidine & Heteropolyoxotungstate PM-19; 3'-Azido-3'-deoxythymidine & Interleukin-1; 3'-Azido-3'-deoxythymidine & Interleukin-2; 3'-Azido-3'-deoxythymidine & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lithium & Erythropoietin; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-1; 3'-Azido-3'-deoxythymidine & Lithium & Interleukin-6; 3'-Azido-3'-deoxythymidine & Lymphoblastoid Interferon; 3'-Azido-3'-deoxythymidine & Sho-Saiko-To; 3'-Azido-3'deoxythymidine & Interferon-alpha; 3'-Azidothymidine; 3'-azido-3'-deoxythymidine, AZT; 3-Azido-3-deoxythymidine; Dendrigen; CTCE-0422
Indication
Disease Entry ICD 11 Status REF
Human immunodeficiency virus infection 1C62 Approved [1]
Diarrhea ME05.1 Investigative [2]
Nephropathy GC2Z Investigative [2]
Virus infection 1A24-1D9Z Investigative [3]
Therapeutic Class
Anti-HIV Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

17 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Zidovudine + Bortezomib DC15WZD Bortezomib Lymphoproliferative Disorder [4]
Zidovudine + Valganciclovir DCASGIS Valganciclovir Lymphoproliferative Disorder [4]
Zidovudine + Valproic Acid DCDLUVT Valproic Acid Lymphoma [5]
Zidovudine + Stavudine DCF9I09 Stavudine HIV Infections [6]
Zidovudine + Lamivudine DCH0XO7 Lamivudine HIV [7]
Zidovudine + Nevirapine DC0IUI3 Nevirapine HIV [8]
Zidovudine + Nevirapine DC88ICA Nevirapine HIV Infections [9]
Zidovudine + Lamivudine DCGON3K Lamivudine HIV Infections [9]
Zidovudine + Efavirenz DCISV1I Efavirenz HIV-1 Infection [10]
Zidovudine + Lamivudine DCPC7VB Lamivudine Human Immunodeficiency Virus [11]
Zidovudine + Lamivudine DC4OLI4 Lamivudine Malaria [12]
Zidovudine + Dolutegravir DCAVBL4 Dolutegravir Human Immunodeficiency Virus [11]
Zidovudine + Efavirenz DCWUOC4 Efavirenz Malaria [12]
Zidovudine + Lamivudine DCZJZHV Lamivudine HIV Infections [13]
Zidovudine + Efavirenz DC4FYY3 Efavirenz HIV [14]
Zidovudine + Didanosine DCIO1M4 Didanosine HIV [14]
Zidovudine + Nevirapine DCWDFWL Nevirapine HIV/AIDS and Infections [15]
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⏷ Show the Full List of 17 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4825).
2 Zidovudine FDA Label
3 The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
4 ClinicalTrials.gov (NCT00092222) Virotherapy and Natural History Study of KHSV-Associated Multricentric Castleman s Disease With Correlates of Disease Activity
5 ClinicalTrials.gov (NCT00854581) Zidovudine, Interferon Alfa-2b, PEG-Interferon Alfa-2b in Patients With HTLV-I Associated Adult T-Cell Leukemia/Lymphoma
6 ClinicalTrials.gov (NCT00528957) Safety and Efficacy of Switching From Stavudine or Zidovudine to Tenofovir DF in HIV-1 Infected Children
7 ClinicalTrials.gov (NCT00960622) Switch From Combivir or Trizivir to Truvada - Mitochondrial Effects
8 ClinicalTrials.gov (NCT02369406) Early Infant HIV Treatment in Botswana
9 ClinicalTrials.gov (NCT00307151) Antiviral Responses to NNRTI-Based vs. PI-Based ARV Therapy in HIV Infected Infants Who Have or Have Not Received Single Dose NVP for Prevention of Mother-to-Child Transmission of HIV
10 ClinicalTrials.gov (NCT01714414) A Trial to Confirm a Sustained Virological Suppression Defined as HIV-RNA <50 Copies/ml of 3 Different Doses of Fozivudine in Context to a Standard Zidovudine Based Antiretroviral Therapy Regimen
11 ClinicalTrials.gov (NCT03988452) Nucleosides And Darunavir/Dolutegravir In Africa
12 ClinicalTrials.gov (NCT00993031) Protease Inhibitors to Reduce Malaria Morbidity in HIV-Infected Pregnant Women
13 ClinicalTrials.gov (NCT02181933) Efficacy of Nevirapine Compared to ZDV + 3TC Administered in Labor and Again at Postdelivery in HIV Positive Women
14 ClinicalTrials.gov (NCT00342355) Antiretroviral Therapy for Advanced HIV Disease in South Africa
15 ClinicalTrials.gov (NCT02712801) Antiretroviral Regime for Viral Eradication in Newborns