General Information of This Drug (ID: DM5DSFZ)

Drug Name
Rifampicin   DM5DSFZ
Synonyms
Rifadin; Rifadine; Rifagen; Rifaldazin; Rifaldazine; Rifaldin; Rifamor; Rifampicin; Rifampicin SV; Rifampicina; Rifampicina [INN-Spanish]; Rifampicine [French]; Rifampicinum; Rifampicinum [INN-Latin]; Rifamycin AMP; Rifaprodin; Rifcin; Rifinah; Rifobac; Rifoldin; Rifoldine; Riforal; Rimactan; Rimactane; Rimactazid; Rimactizid; Rimazid; Sinerdol; Tubocin; Archidyn; Arficin; Arzide; Benemicin; Dione 21-acetate; Doloresum; Eremfat; Fenampicin; L-5103 Lepetit; rifampin; 13292-46-1; Abrifam; Ba 41166/E; R/AMP; Rifa; Rifam
Indication
Disease Entry ICD 11 Status REF
Non-insulin dependent diabetes 5A11 Approved [1]
Pulmonary tuberculosis 1B10.Z Approved [2]
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

79 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
AKB-6548 + Rifampicin DCDNBV8 AKB-6548 Drug Interaction Potentiation [3]
Bedaquiline + Rifampicin DCY5P0R Bedaquiline Tuberculosis [4]
BMS-708163 + Rifampicin DC9YK33 BMS-708163 Alzheimer Disease [5]
Crizotinib + Rifampicin DCGQSU9 Crizotinib Non-Small Cell Lung Cancer ALK-positive [6]
Etidronic acid + Rifampicin DCHU72A Etidronic acid NASH - Nonalcoholic Steatohepatitis [7]
Istradefylline + Rifampicin DCJYZVO Istradefylline Parkinson's Disease [8]
Ixabepilone + Rifampicin DCL21D9 Ixabepilone Advanced Solid Tumors [9]
Methotrexate + Rifampicin DCEAFKR Methotrexate Drug Interaction [10]
Methotrexate + Rifampicin DC6YRVT Methotrexate Drug Interaction [10]
MK-1775 + Rifampicin DCO7VD4 MK-1775 Advanced Solid Tumours [11]
N91115 + Rifampicin DCY8T6Q N91115 Drug Interaction Potentiation [12]
Pyrazinamide + Rifampicin DCINLE8 Pyrazinamide HIV Infections [13]
Pyrazinamide + Rifampicin DCUYWK5 Pyrazinamide Pulmonary Tuberculosis [14]
RDEA3170 + Rifampicin DCTK4K9 RDEA3170 Chronic Kidney Disease [15]
Rifampicin + Atazanavir DC2BHD2 Atazanavir HIV Infections [16]
Rifampicin + Lumacaftor DC3GF8W Lumacaftor Cystic Fibrosis [17]
Rifampicin + Ethambutol DCAS3RT Ethambutol Cystic Fibrosis [18]
Rifampicin + Mirabegron DC0VJUT Mirabegron Pharmacokinetics of YM178 [19]
Rifampicin + Efavirenz DC1VXQW Efavirenz Tuberculosis [20]
Rifampicin + Fostamatinib DC5G79Z Fostamatinib Rheumatoid Arthritis [21]
Rifampicin + Colistimethate DC5O30T Colistimethate Infection Due to Resistant Bacteria [22]
Rifampicin + SQ-109 DC73XM4 SQ-109 Tuberculosis, Pulmonary [23]
Rifampicin + Naloxegol DC7DUJW Naloxegol Drug Induced Constipation [24]
Rifampicin + Buprenorphine DC7U9JS Buprenorphine Opioid Dependency [25]
Rifampicin + Sitaxsentan DCCUNQH Sitaxsentan Pulmonary Arterial Hypertension [26]
Rifampicin + Vemurafenib DCDN8XS Vemurafenib Malignant Melanoma, Neoplasms [27]
Rifampicin + Doxycycline DCFPB9U Doxycycline Alzheimer's Disease [28]
Rifampicin + Darexaban maleate DCFVQJW Darexaban maleate Pharmacokinetics of Darexaban and Metabolites [29]
Rifampicin + Isoniazid DCJ2QX2 Isoniazid HIV Infections [30]
Rifampicin + Efavirenz DCJUT3M Efavirenz HIV Infections [31]
Rifampicin + Dapagliflozin DCLDI8S Dapagliflozin Type 2 Diabetes Mellitus [32]
Rifampicin + ABT-869 DCN0MSW ABT-869 Advanced Solid Tumors [33]
Rifampicin + Fusidic acid DCQY3NA Fusidic acid Prosthetic Joint Infections of Hip [34]
Rifampicin + Nevirapine DCU1EM3 Nevirapine Tuberculosis [20]
Rifampicin + Romidepsin DCV7QYD Romidepsin Hematologic Malignancy [35]
Rifampicin + Pretomanid DCXHPD3 Pretomanid Tuberculosis [36]
Rifampicin + Vemurafenib DC9T6KK Vemurafenib Metastatic Melanoma, BRAF V600 Mutation Positive [37]
Rifampicin + Fluconazole DCRLENZ Fluconazole Drug Interactions [38]
Rifampicin + CC-292 DC3WRAU CC-292 Multiple Sclerosis [39]
Rifampicin + Venetoclax DC4WBX2 Venetoclax Non-Hodgkin's Lymphoma [40]
Rifampicin + Clarithromycin DC76VL2 Clarithromycin Vitamin D and Calcium Homeostasis [41]
Rifampicin + MLN8237 DCASU1Q MLN8237 Solid Tumors [42]
Rifampicin + Savolitinib DCBRZ86 Savolitinib Solid Tumors [43]
Rifampicin + Tucatinib DCDEWWJ Tucatinib Drug-drug Interaction [44]
Rifampicin + Tesetaxel DCG7PMD Tesetaxel Advanced Solid Tumors [45]
Rifampicin + GSK2140944 DCH8CB0 GSK2140944 Infections, Bacterial [46]
Rifampicin + Enzalutamide DCIRHWQ Enzalutamide Drug-Drug Interaction (DDI) [47]
Rifampicin + Fruquintinib DCJYO0E Fruquintinib Drug Drug Interaction [48]
Rifampicin + Celecoxib DCM4WGS Celecoxib Tuberculosis [49]
Rifampicin + CC-220 DCMCXV3 CC-220 Pharmacokinetics [50]
Rifampicin + Bay 80-6946 DCNACZB Bay 80-6946 Medical Oncology [51]
Rifampicin + Ecopipam DCOGR9I Ecopipam Drug Interaction [52]
Rifampicin + Daptomycin DCPGIQB Daptomycin Drug Interactions [53]
Rifampicin + Tazemetostat DCTMVIN Tazemetostat All Malignancies [54]
Rifampicin + Selumetinib DCTPVSF Selumetinib Solid Tumours [55]
Rifampicin + Dolutegravir DCXPJIN Dolutegravir HIV-1-infection [56]
Talazoparib + Rifampicin DCKM1N2 Talazoparib Advanced Solid Tumors [57]
Pyrazinamide + Rifampicin DC12V6F Pyrazinamide Pulmonary Tuberculosis [14]
Pyrazinamide + Rifampicin DC1OE7W Pyrazinamide Tuberculosis, Pulmonary [58]
Pyrazinamide + Rifampicin DC3RVJ3 Pyrazinamide Pulmonary Tuberculosis [59]
Pyrazinamide + Rifampicin DCHBK4S Pyrazinamide Tuberculous Meningitis [60]
Pyrazinamide + Rifampicin DCL3W1O Pyrazinamide Tuberculosis, Pulmonary [61]
Pyrazinamide + Rifampicin DCM10XF Pyrazinamide HIV [62]
Pyrazinamide + Rifampicin DCS8QNC Pyrazinamide Tuberculosis [63]
Pyrazinamide + Rifampicin DCV4XRW Pyrazinamide Pulmonary Tuberculosis [64]
Pyrazinamide + Rifampicin DC0032N Pyrazinamide Tuberculosis [63]
Pyrazinamide + Rifampicin DCP9KAD Pyrazinamide Pulmonary Tuberculosis [64]
Pyrazinamide + Rifampicin DCW719W Pyrazinamide Tuberculosis, Pulmonary [61]
Rifabutin + Rifampicin DC1JG10 Rifabutin Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD) [65]
Rifampicin + Ethambutol DCZE88D Ethambutol Sarcoidosis; Antimycobacterial Therapy [66]
Rifampicin + Amoxicillin DC7HP6G Amoxicillin Pulmonary Tuberculosis [67]
Pyrazinamide + Rifampicin DC32Y86 Pyrazinamide Tuberculosis [68]
Pyrazinamide + Rifampicin DCLTLMK Pyrazinamide Pulmonary Tuberculosis [69]
Pyrazinamide + Rifampicin DCMBY9E Pyrazinamide Tuberculosis, Pulmonary [70]
Rifampicin + Clarithromycin DCLFKJ7 Clarithromycin Lung Infection [71]
Rifampicin + Ethambutol DCVPBCS Ethambutol Lung Infection [71]
Rifampicin + Levofloxacin DCL6ZHG Levofloxacin Infective Endocarditis [72]
Pyrazinamide + Rifampicin DCE7UI3 Pyrazinamide Tuberculosis, Pulmonary [73]
Rifampicin + Ethambutol DCTTE4F Ethambutol Nontuberculous Mycobacterial Lung Disease [74]
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⏷ Show the Full List of 79 DrugCom(s)

References

1 Inhibitors can arrest the membrane activity of human islet amyloid polypeptide independently of amyloid formation. FEBS Lett. 2001 Oct 26;507(2):200-4.
2 Xpert MTB/RIF Ultra assay for tuberculosis disease and rifampicin resistance in children. Cochrane Database Syst Rev. 2022 Sep 6;9(9):CD013359.
3 ClinicalTrials.gov (NCT03801746) Drug-Drug Interaction Study of Vadadustat With Cyclosporine, Probenecid and Rifampin
4 ClinicalTrials.gov (NCT01341184) TMC207 +/- Rifabutin/Rifampin
5 ClinicalTrials.gov (NCT01002079) Drug-Drug Interaction Study With Rifampin
6 ClinicalTrials.gov (NCT00585195) A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer
7 ClinicalTrials.gov (NCT03213145) Drug-drug Interaction Study Between EDP-305, Intraconazole and Rifampin in Healthy Volunteers
8 ClinicalTrials.gov (NCT02174250) The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.
9 ClinicalTrials.gov (NCT00207090) Effect of Rifampin on the Pharmacokinetics of Ixabepilone in Patients With Advanced Cancer
10 ClinicalTrials.gov (NCT05575297) A Drug-drug Interaction Study to Evaluate the Effect of Rifampicin and Febuxostat on the Pharmacokinetics of Methotrexate in Healthy Subjects
11 ClinicalTrials.gov (NCT04959266) A Study to Assess the Effects of Itraconazole, Rifampicin, and Omeprazole on Pharmacokinetics of Adavosertib
12 ClinicalTrials.gov (NCT02500667) A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects
13 ClinicalTrials.gov (NCT00042289) Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy
14 ClinicalTrials.gov (NCT02554318) Fermented Soybean Supplementation Among Active Pulmonary Tuberculosis Patients With Standard Therapy in Indonesia
15 ClinicalTrials.gov (NCT04532918) Pharmacokinetics of Verinurad and Allopurinol in Combination With Cyclosporine and Rifampicin in Healthy Volunteers
16 ClinicalTrials.gov (NCT00096850) Safety, Tolerability, and Blood Levels of Ritonavir-Boosted Atazanavir and Rifampin When Taken Together in HIV Uninfected Adults
17 ClinicalTrials.gov (NCT01768663) A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects
18 ClinicalTrials.gov (NCT02372383) Improving Treatment of Nontuberculous Mycobacterial Infection in Cystic Fibrosis
19 ClinicalTrials.gov (NCT00776516) Pharmacokinetic Interaction Study to Assess the Effect of Repeat Doses of Rifampin on Mirabegron (YM178) in Healthy Volunteers
20 ClinicalTrials.gov (NCT00495326) Comparison of Nevirapine and Efavirenz for the Treatment of HIV-TB Co-infected Patients (ANRS 12146 CARINEMO)
21 ClinicalTrials.gov (NCT01336218) Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.
22 ClinicalTrials.gov (NCT01577862) Colistin and Rifampicin for MDR-Acinetobacter
23 ClinicalTrials.gov (NCT01218217) Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB
24 ClinicalTrials.gov (NCT01533870) Study in Healthy Volunteers to Investigate the Effects of Rifampin on the Pharmacokinetics of NKTR-118
25 ClinicalTrials.gov (NCT00877591) Interaction of Buprenorphine With HIV Medications and Tuberculosis Medications
26 ClinicalTrials.gov (NCT01251835) Effect Of Rifampin On Pharmacokinetics Of Sitaxsentan
27 ClinicalTrials.gov (NCT01765543) A Pharmacokinetics (PK) Study to Investigate the Effect of Rifampin on PK of Vemurafenib (Zelboraf)
28 ClinicalTrials.gov (NCT00439166) Effects of Doxycycline and Rifampicin on Biomarkers of Alzheimer's Disease in the Cerebrospinal Fluid
29 ClinicalTrials.gov (NCT01406002) To Evaluate if Multiple Doses of Rifampicin Change the Blood Concentration of YM150 (Darexaban)
30 ClinicalTrials.gov (NCT00057122) Tuberculosis Prevention for HIV Infected Adults
31 ClinicalTrials.gov (NCT00802802) Efavirenz (EFV) in HIV-Infected and HIV/Tuberculosis (TB) Coinfected Children
32 ClinicalTrials.gov (NCT01068756) Effect of Rifampin on the Pharmacokinetics of Dapagliflozin in Healthy Subjects
33 ClinicalTrials.gov (NCT01401933) Effect of Rifampin on the Pharmacokinetics of Linifanib in Subjects With Advanced or Metastatic Solid Tumors
34 ClinicalTrials.gov (NCT01756924) Safety and Efficacy of CEM-102 With Rifampin Compared to Standard Therapy in Patients With Prosthetic Joint Infections or Spacer Infection
35 ClinicalTrials.gov (NCT01324323) Influence of Rifampin on the Pharmacokinetics of Romidepsin in Patients With Advanced Cancer
36 ClinicalTrials.gov (NCT01571414) Evaluating the Safety and Drug Interaction of PA-824, an Investigational Tuberculosis Medication, Together With Efavirenz, Ritonavir-Boosted Lopinavir, or Rifampin
37 ClinicalTrials.gov (NCT02608034) A Study to Investigate the Effect of Itraconazole and Rifampin on Pharmacokinetics (PK) of Vemurafenib at Steady State
38 ClinicalTrials.gov (NCT00964106) Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
39 ClinicalTrials.gov (NCT06064539) Study of Drug-drug Interaction of the Effects of Gemfibrozil and Rifampicin on SAR442168 in Healthy Adult Subjects
40 ClinicalTrials.gov (NCT01969682) A Study to Assess the Effect of Rifampin on the Metabolism of ABT-199
41 ClinicalTrials.gov (NCT02019875) CYP3A4 Activity and Mineral Homeostasis
42 ClinicalTrials.gov (NCT01844583) Safety, Tolerability and Pharmacokinetic (PK) of Concomitant Esomeprazole and Rifampin, and QT Study on Single and Multiple-doses of Alisertib
43 ClinicalTrials.gov (NCT04118842) A Study in Healthy Subjects to Assess the Pharmacokinetics of Savolitinib When Administered Alone and in Combination With Rifampicin
44 ClinicalTrials.gov (NCT03723395) A Drug-Drug Interaction Study in Healthy Volunteers of the Effects of Tucatinib
45 ClinicalTrials.gov (NCT04312282) The Effect of Tesetaxel on the QTc Interval and the Effect of Food, Itraconazole, and Rifampin on Tesetaxel Pharmacokinetics in Patients With Advanced Solid Tumors
46 ClinicalTrials.gov (NCT04493931) Drug-drug Interaction Study of Gepotidacin
47 ClinicalTrials.gov (NCT02138799) A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men
48 ClinicalTrials.gov (NCT04557397) Fruquintinib CYP3A Inhibitor and Inducer Study
49 ClinicalTrials.gov (NCT02602509) Evaluating Celecoxib Activity in Mycobacterium Tuberculosis: A Whole Blood Bactericidal Activity Study in Healthy Volunteers
50 ClinicalTrials.gov (NCT02820935) Study to Evaluate the Effect of Cytochrome P450 (CYP) 3A Inhibition and Induction on the Pharmacokinetics of CC-220 in Healthy Subjects
51 ClinicalTrials.gov (NCT02253420) COPANLISIB (BAY80-6946) Drug-drug Interaction and Cardiovascular Safety Study in Advanced Solid Tumor and Non-Hodgkin's Lymphoma Patients
52 ClinicalTrials.gov (NCT06194864) Drug Interaction Study
53 ClinicalTrials.gov (NCT02097953) Influence of Rifampin Co-Administration on the Pharmacokinetic Profile of Daptomycin
54 ClinicalTrials.gov (NCT04537715) Study to Describe the Interaction Between Tazemetostat and Itraconazole and Between Tazemetostat and Rifampin in Participants With Advanced Cancer
55 ClinicalTrials.gov (NCT02046850) To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers
56 ClinicalTrials.gov (NCT03199690) A Clinical Study Investigating Rifampicin and Dolutegravir in Combination in Healthy Volunteers
57 ClinicalTrials.gov (NCT03077607) A Study to Evaluate the Effect of Itraconazole and Rifampin on the Pharmacokinetics of Talazoparib in Patients With Advanced Solid Tumors
58 ClinicalTrials.gov (NCT05766267) Short-course Regimens for the Treatment of Pulmonary Tuberculosis
59 ClinicalTrials.gov (NCT02256696) Assessing PA-824 for Tuberculosis (the APT Trial)
60 ClinicalTrials.gov (NCT05383742) Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis
61 ClinicalTrials.gov (NCT01785186) Evaluation of SQ109, High-dose Rifampicin, and Moxifloxacin in Adults With Smear-positive Pulmonary TB in a MAMS Design
62 ClinicalTrials.gov (NCT04311502) Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study
63 ClinicalTrials.gov (NCT01589497) Essentiality of INH in TB Therapy
64 ClinicalTrials.gov (NCT05807399) PanACEA - STEP2C -01
65 ClinicalTrials.gov (NCT04630145) A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
66 ClinicalTrials.gov (NCT02024555) Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis
67 ClinicalTrials.gov (NCT05896930) Study to Evaluate EBA, Safety and Tolerability of Carbapenems in Adults With Pulmonary Tuberculosis
68 ClinicalTrials.gov (NCT00130247) Tuberculosis Treatment Shortening Trial
69 ClinicalTrials.gov (NCT02581527) A Randomised Trial to Evaluate Toxicity and Efficacy of 1200mg and 1800mg Rifampicin for Pulmonary Tuberculosis
70 ClinicalTrials.gov (NCT04485156) Treatment Shortening of Drug-Sensitive Pulmonary Tuberculosis Using High Dose Rifampicin (Hi-DoRi-3)
71 ClinicalTrials.gov (NCT03236987) CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections
72 ClinicalTrials.gov (NCT02701608) Oral Switch During Treatment of Left-sided Endocarditis Due to Multi-susceptible Staphylococcus
73 ClinicalTrials.gov (NCT02901288) Shortened Regimens for Drug-susceptible Pulmonary Tuberculosis
74 ClinicalTrials.gov (NCT04921943) Hypertonic Saline for MAC