Details of the Drug Combinations

General Information of This Drug (ID: DM5IKUF)

Drug Name

Dihydroergotamine DM5IKUF

Synonyms

Migranal (TN)

Indication

Disease Entry	ICD 11	Status	REF
Cluster headache	8A81.0	Approved	[1]
Migraine	8A80	Approved	[2]
Migraine disorder	N.A.	Approved	[1]
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Therapeutic Class

Antimigraine Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

86 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Abacavir + Dihydroergotamine	DCLVXJA	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Albendazole + Dihydroergotamine	DCYJ2VK	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Aprepitant + Dihydroergotamine	DCB2BMM	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Bortezomib + Dihydroergotamine	DCG0Y31	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BREQUINAR + Dihydroergotamine	DCPIY4C	BREQUINAR	DD2 (Cell Line: DD2)	[3]
BREQUINAR + Dihydroergotamine	DC83T2W	BREQUINAR	Hepatoblastoma (Cell Line: HB3)	[4]
Brincidofovir + Dihydroergotamine	DC9OGSW	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Dihydroergotamine	DCBXDGP	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chloroquine + Dihydroergotamine	DCEFVES	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlorzoxazone + Dihydroergotamine	DCJHKOT	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Citalopram + Dihydroergotamine	DCAW8F3	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Dihydroergotamine	DCXRKWR	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Daidzin + Dihydroergotamine	DC6ZLKZ	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dichlorphenamide + Dihydroergotamine	DCWEDHD	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diethylcarbamazine + Dihydroergotamine	DCGQECV	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Aliskiren	DCSAX0J	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + OZ277	DC1L1IY	OZ277	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Lumefantrine	DCOXVP8	Lumefantrine	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Lumefantrine	DC5XFS7	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Kanamycin	DC0QKCY	Kanamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + T-3.5	DC9X1NR	T-3.5	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Artemether	DCX4ZWB	Artemether	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Miglustat	DCB34Q9	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Vinblastine	DCQAFBU	Vinblastine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Verapamil	DC3LFRE	Verapamil	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Diltiazem	DC4DFEP	Diltiazem	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Diltiazem	DC6Q4R7	Diltiazem	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + IT-141	DCL7BK1	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Thiolactomycin	DCYVO5F	Thiolactomycin	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Proguanil	DCRLPBR	Proguanil	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Metyrosine	DCY97I3	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Doxapram	DC5N21B	Doxapram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Docetaxel	DCV3HEV	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Sarpogrelate	DC4HI4C	Sarpogrelate	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Sarpogrelate	DC1LIKE	Sarpogrelate	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Ivermectin	DC38QCG	Ivermectin	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Arfolitixorin	DCX7AHO	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + BIO-300	DC04T1E	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + SB 228357	DCCTEKT	SB 228357	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + SB 228357	DCOUAC8	SB 228357	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Diazoxide	DCLZIG9	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Methocarbamol	DC808VA	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Methylene blue	DCNZCS9	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Mesalazine	DCTLLWP	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Olanzapine	DCUHINJ	Olanzapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Trimethobenzamide	DC8IRZ4	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Leflunomide	DCR1A5O	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Quinine	DCF2GE1	Quinine	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + MK-4815	DCL2CMH	MK-4815	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Endoxifen	DC4GGQG	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Mycophenolic acid	DCFOF3H	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Bifemelane	DCAN9S7	Bifemelane	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Ritonavir	DCOYB3J	Ritonavir	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Ritonavir	DCIOUJD	Ritonavir	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Mefloquine	DCEATEO	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Mefloquine	DCV6JJQ	Mefloquine	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Pizotyline	DC4KNO3	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Zileuton	DCE3MPC	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Nitisinone	DCUCA12	Nitisinone	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Auranofin	DCB6O31	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Vorinostat	DCZL6US	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Atovaquone	DC6EAOO	Atovaquone	DD2 (Cell Line: DD2)	[3]
Dihydroergotamine + Atovaquone	DCE9SXH	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[3]
Dihydroergotamine + Enoxacin	DCGRIKW	Enoxacin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Raltegravir	DCJO4I8	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dihydroergotamine + Azatadine	DC3R8WC	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Doxorubicin + Dihydroergotamine	DCUH6A3	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Dihydroergotamine	DCOL4GE	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etonogestrel + Dihydroergotamine	DCRRS0R	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fenoprofen + Dihydroergotamine	DC7I0NM	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + Dihydroergotamine	DCMICZA	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ivermectin + Dihydroergotamine	DCRSX37	Ivermectin	DD2 (Cell Line: DD2)	[3]
Levamisole + Dihydroergotamine	DCB4ISZ	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maprotiline + Dihydroergotamine	DCLP5ZB	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Dihydroergotamine	DCWSUTZ	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Dihydroergotamine	DCX79OO	Miconazole	DD2 (Cell Line: DD2)	[3]
Miconazole + Dihydroergotamine	DCDE3MC	Miconazole	Hepatoblastoma (Cell Line: HB3)	[4]
Nitisinone + Dihydroergotamine	DCNIZ7E	Nitisinone	DD2 (Cell Line: DD2)	[3]
Pargyline + Dihydroergotamine	DCETNN1	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Dihydroergotamine	DCGLQVN	Paromomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Phensuximide + Dihydroergotamine	DCY48WT	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sarpogrelate + Dihydroergotamine	DCL078C	Sarpogrelate	DD2 (Cell Line: DD2)	[3]
Sarpogrelate + Dihydroergotamine	DCDRZWM	Sarpogrelate	Hepatoblastoma (Cell Line: HB3)	[4]
Sorafenib + Dihydroergotamine	DCHOGHQ	Sorafenib	DD2 (Cell Line: DD2)	[3]
Tropisetron + Dihydroergotamine	DCV19S0	Tropisetron	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
ZM-447439 + Dihydroergotamine	DCKEB13	ZM-447439	DD2 (Cell Line: DD2)	[3]
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⏷ Show the Full List of 86 DrugCom(s)

1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dihydroergotamine + Valproic Acid	DC5I0RU	Valproic Acid	Migraine in Children	[5]
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References

1	Dihydroergotamine FDA Label
2	Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT03885154) Valproic Acid and Dihydroergotamine as Abortive Therapy in Pediatric Migraine