Details of the Drug Combinations

General Information of This Drug (ID: DM6ETS0)

Drug Name

Deferasirox DM6ETS0

Synonyms

Deferasirox; Deferasirox (Exjade); Deferasiroxum; Deferasiroxum [INN-Latin]; Exjade; V8G4MOF2V9; 201530-41-8; 4-(3,5-Bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl)benzoic acid; 4-[3,5-Bis(2-hydroxyphenyl)-1,2,4-triazol-1-yl]benzoic acid; 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]benzoic acid; Benzoic acid, 4-[3,5-bis(2-hydroxyphenyl)-1H-1,2,4-triazol-1-yl]-; C21H15N3O4; CGP-72670; CHEBI:49005; DSSTox_CID_28522; DSSTox_RID_82794; ICL 670; ICL 670A; ICL-670; ICL-670A; ICL670; ICL670A; NCGC00181754-01; UNII-V8G4MOF2V9

Indication

Disease Entry	ICD 11	Status	REF
Beta thalassemia	3A50.2	Approved	[1]
Iron overload disease	5C64.10	Approved	[1]
Iron metabolism disease	N.A.	Investigative	[1]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Deferasirox + Idarubicin	DC41RXC	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Deferasirox + Amlodipine	DCO8L46	Amlodipine	Beta-Thalassemia	[3]
Deferasirox + Deferoxamine	DCQYS9G	Deferoxamine	Sickle Cell Disease	[4]
Deferasirox + Cytarabine	DC80O5T	Cytarabine	Acute Myeloid Leukemia	[5]
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References

1	Deferasirox FDA Label
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT02474420) Amlodipine as Adjuvant Treatment to Iron Chelation for Prevention of Cardiac Iron Overload in Thalassemia Patients
4	ClinicalTrials.gov (NCT00110617) Study of Deferasirox Relative to Subcutaneous Deferoxamine in Sickle Cell Disease Patients
5	ClinicalTrials.gov (NCT02413021) The Effect of Deferasirox on Response Rate of Acute Leukemia Patients Not Treated by Standard Chemotherapy Regimens