Details of the Drug Combinations

General Information of This Drug (ID: DM6PBUM)

Drug Name
Birinapant   DM6PBUM
Synonyms
Birinapant; 1260251-31-7; Birinapant (TL32711); TL-32711; UNII-6O4Z07B57R; TL 32711; 6O4Z07B57R; (2S)-N-[(2S)-1-[(2R,4S)-2-[[6-fluoro-2-[6-fluoro-3-[[(2R,4S)-4-hydroxy-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidin-2-yl]methyl]-1H-indol-2-yl]-1H-indol-3-yl]methyl]-4-hydroxypyrrolidin-1-yl]-1-oxobutan-2-yl]-2-(methylamino)propanamide
Indication
Disease Entry ICD 11 Status REF
Lymphoma 2A80-2A86 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [2]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Birinapant + Ruxolitinib DC6V792 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Birinapant + Prochlorperazine DCMRJAY Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Birinapant + RAF265 DCMFR5G RAF265 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Birinapant + Mifepristone DCPEYKZ Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Birinapant + Idarubicin DCX1PK4 Idarubicin Glioblastoma? (Cell Line: T98G) [3]
Birinapant + ABT-263 DC9DWNN ABT-263 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
------------------------------------------------------------------------------------
⏷ Show the Full List of 6 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Birinapant + Azacitidine DCHXQNE Azacitidine Myelodysplastic Syndrome [4]
------------------------------------------------------------------------------------

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7432).
2 Small molecules, big targets: drug discovery faces the protein-protein interaction challenge.Nat Rev Drug Discov. 2016 Aug;15(8):533-50.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 ClinicalTrials.gov (NCT01828346) Birinapant With 5-azacitidine in MDS Subjects Who Are Nave, Have Relapsed or Are Refractory to 5-azacitidine Therapy