Details of the Drug Combinations

General Information of This Drug (ID: DM6V34C)

Drug Name

Marimastat DM6V34C

Synonyms

Marimastat [USAN]; BB 2516; BB-2516; Marimastat (USAN/INN); (2R,3S)-N-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N',3-dihydroxy-2-(2-methylpropyl)butanediamide; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoyl)propyl)carbamoyl)-2-hydroxy-5-methylhexanohydroxamic acid; (2S,3R)-N(4)-[(2S)-3,3-dimethyl-1-(methylamino)-1-oxobutan-2-yl]-N(1),2-dihydroxy-3-(2-methylpropyl)butanediamide

Indication

Disease Entry	ICD 11	Status	REF
Pancreatic cancer	2C10	Phase 3	[1]
Lung cancer	2C25.0	Discontinued in Phase 3	[1]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Marimastat + Panobinostat	DCIMDEA	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Marimastat + CA4P	DCZTE63	CA4P	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Marimastat + BMS-754807	DCXHQ69	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Marimastat + E7820	DCWOTHC	E7820	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + Marimastat	DCBZGOR	Prochlorperazine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5220).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.