Details of the Drug Combinations

General Information of This Drug (ID: DM7F1PA)

Drug Name

Nebivolol DM7F1PA

Synonyms

Bystolic; Lobivon; Nebilet; Nebilong; Nebipill; Nebivololum; Nubeta; Nebivololum [Latin]; R 67555; Bystolic (TN); Nebicard-5;Nebilet (TN); Nebilong (TN); Nodon (TN); Nubeta (TN); PI-21858; R-67555; R65,824; Nebicard-5 (TN); Nebivolol (USAN/INN); Nebivolol [USAN:INN:BAN]; Alpha,alpha'-(Iminodimethylene)bis(6-fluoro-2-chromanmethanol); Alpha,alpha'-(Iminobis(methylene))bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol); Alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol; 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol; 2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol]

Indication

Disease Entry	ICD 11	Status	REF
Hypertension	BA00-BA04	Approved	[1]
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Therapeutic Class

Antihypertensive Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Nebivolol + Metoprolol	DC5SYJY	Metoprolol	Hypertension	[2]
Nebivolol + Metoprolol	DCY5WX6	Metoprolol	High Blood Pressure	[3]
Nebivolol + Hydrochlorothiazide	DC2AS4A	Hydrochlorothiazide	Hypertension	[4]
Nebivolol + Amlodipine	DC70WV4	Amlodipine	Hypertension	[5]
Nebivolol + Ramipril	DCZC0T9	Ramipril	Hypertension	[6]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7246).
2	ClinicalTrials.gov (NCT01041287) Effect of Nebivolol on Oxidative Stress and Endothelial Progenitor Cells
3	ClinicalTrials.gov (NCT01049009) The Effect of Nebivolol on Endothelial Dysfunction in African Americans With Hypertension
4	ClinicalTrials.gov (NCT02710071) Treatment of OSA Associated Hypertension With Nebivolol or Hydrochlorothiazide
5	ClinicalTrials.gov (NCT05513937) Effectiveness and Safety of Combination of Nebivolol and Amlodipine in Hypertensive Patients Versus Each Monotherapy
6	ClinicalTrials.gov (NCT06104423) Open-label, Multicenter, multinAtionaL, inteRventional Clinical Trial to Assess Efficacy and Safety of the exteMporaneous combInation of Nebivolol and Ramipril in hypertenSIve pAtients