General Information of This Drug (ID: DM7HUNW)

Drug Name
Testosterone   DM7HUNW
Synonyms
AndroGel; Androderm; Androlin; Andronaq; Andropatch; Androsorb; Andrusol; Depotest; Halotensin; Homosteron; Homosterone; Intrinsa; LibiGel; Malerone; Mertestate; Neotestis; Oreton; Orquisteron; Perandren; Primotest; Primoteston; Relibra; Striant; Sustanon; Sustanone; Teslen; Testandrone; Testaqua; Testiculosterone; Testim; Testobase; Testoderm; Testogel; Testolin; Testopropon; Testosteroid; Testosteron; Testosterona; Testosteronum; Testostosterone; Testoviron; Testrone; Testryl; Virormone; Virosterone; Beta testosterone; Cristerona T; Cristerone T; Malogen in Oil; Oreton F; Percutacrine androgenique; Synandrol F; Testoderm Tts; Testopel Pellets; Testosterone and its esters; Testosterone hydrate; Testosterone solution; Testoviron Schering; Testoviron T; Testro AQ; Virilon IM; AA 2500; Andro 100; Andronate 100; Andronate 200; Andropository 200; Andryl 200; CDB 111C; CMC_13449; COL 1621; CP 601B; Everone 200; Sustason 250; Testamone 100; Testred Cypionate 200; Androderm (TN); Androgel (TN); Geno-cristaux gremy; Malestrone (amps); Malogen, aquaspension injection; Neo-Hombreol F; Neo-testis; Oreton-F; Scheinpharm Testone-Cyp; Striant (TN); T-Cypionate; Testim (TN); Testoject-50; Testosterona [INN-Spanish]; Testosterone [Androgenic steroids, anabolic]; Testosterone [INN:BAN]; Testosteronum [INN-Latin]; Trans-Testosterone; Testosterone (JAN/USP); Testrin-P.A; Delta4-Androsten-17beta-ol-3-one; Delta4-androsten-17b-ol-3-one; Androst-4-en-17beta-ol-3-one; Delta(sup 4)-Androsten-17(beta)-ol-3-one; (17beta)-17-Hydroxyandrost-4-en-3-one; (8R,9S,10R,13S,14S,17S)-17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one; 17-Hydroxy-(17-beta)-androst-4-en-3-one; 17-Hydroxy-(17beta)-androst-4-en-3-one; 17-Hydroxy-4-androsten-3-one; 17-beta-Hydroxy-delta(sup 4)-androsten-3-one; 17-beta-Hydroxyandrost-4-en-3-one; 17b-hydroxy-4-androsten-3-one; 17beta-Hydroxy-3-oxo-4-androstene; 17beta-Hydroxy-4-androsten-3-one; 17beta-Hydroxy-delta(sup4)-androsten-3-one; 17beta-Hydroxyandrost-4-en-3-one; 17beta-Hydroxyandrost-4-ene-3-one; 4-Androsten-17-ol-3-one; 4-Androsten-17beta-ol-3-one; 4-androstene-17beta-ol-3-one; 7-beta-Hydroxyandrost-4-en-3-one
Indication
Disease Entry ICD 11 Status REF
Hot flushes GA30 Approved [1]
Hypogonadism 5A61.0 Approved [1]
Hypogonadotropic hypogonadism N.A. Approved [1]
Hypopituitarism N.A. Approved [1]
Multiple sclerosis 8A40 Approved [1]
Osteoporosis FB83.0 Approved [2]
Woodhouse-Sakati syndrome N.A. Approved [1]
Hormone deficiency 5A61.1 Phase 2 [3]
Hypogonadism, male N.A. Investigative [1]
Male hormonal deficiency 5A81 Investigative [4]
⏷ Show the Full List of Indication(s)
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

58 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Testosterone DCOKJT3 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Acamprosate + Testosterone DCAGHL3 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Amiloride + Testosterone DCFVRKT Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Amodiaquine + Testosterone DCWSY96 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Arfolitixorin + Testosterone DC0SXWN Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
AS-1949490 + Testosterone DCJ4K2Z AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Auranofin + Testosterone DC7DRRM Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bortezomib + Testosterone DCYZWG5 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Bosentan + Testosterone DCEQNDY Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Brincidofovir + Testosterone DC39HIQ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Cisatracurium + Testosterone DCWA89I Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Diphenidol + Testosterone DCTVUUD Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Docetaxel + Testosterone DCKUIMM Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Estramustine + Testosterone DC99KXR Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Imatinib + Testosterone DC8TOXE Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Isoproterenol + Testosterone DCYZMAT Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Kanamycin + Testosterone DCWCCTQ Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Levamisole + Testosterone DCY4PQP Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Maprotiline + Testosterone DCWPF9C Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Memantine + Testosterone DCXSWUT Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Mycophenolic acid + Testosterone DC0X242 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Naltrexone + Testosterone DCMODBZ Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Quinine + Testosterone DCSQ1N8 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Sulfinpyrazone + Testosterone DCUS0XL Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Lefaxin DCTEK4V Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Bepridil DCS5LWP Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Gefitinib DCWP8OE Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Ruxolitinib DC2CU5W Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [5]
Testosterone + PMID28460551-Compound-2 DCUD4X7 PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Anamorelin DCIL1N1 Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Fomepizole DCWWZ66 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Triapine DCTN6SJ Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Everolimus DCP9YY7 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Pepstatin DCV5PHQ Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Rifampin DCYIVEQ Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + IT-141 DCW8E7C IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Methylergonovine DCUAOEG Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Metyrosine DCCHOKD Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Itraconazole DCD0G67 Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Chlorzoxazone DCBMLRV Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + BIO-300 DCFDBDW BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + PF-02545920 DCF0XJA PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Trazodone DCSDI3B Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Idarubicin DCZYYU8 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Artemisinin DCNZS58 Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Topotecan DCMXFCX Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Trimethobenzamide DC4CH8F Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Oxyphenbutazone DCTJSE2 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Leflunomide DCYVR1S Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Pomalidomide DCR1BH2 Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Endoxifen DC1FKCS Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Mefloquine DC8VEW6 Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Doxorubicin DC3WPFY Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Silver sulfadiazine DCHQVT4 Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Vorinostat DCJKSZG Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Aciclovir DCR1OKS Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Nitrosoglutathione DCW64KK Nitrosoglutathione Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
Testosterone + Cytarabine DCI6886 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [5]
------------------------------------------------------------------------------------
⏷ Show the Full List of 58 DrugCom(s)
17 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Leuprolide + Testosterone DCR3QLK Leuprolide Hypertension [6]
Leuprolide + Testosterone DCNRTBR Leuprolide Obesity [7]
Risedronate + Testosterone DCIABDR Risedronate Anorexia Nervosa [8]
Sildenafil + Testosterone DC1ZD7V Sildenafil Hypoactive Sexual Desire Disorder [9]
Testosterone + Dutasteride DC5K27A Dutasteride Aging [10]
Testosterone + Nestorone DC6ENDT Nestorone Contraception [11]
Testosterone + Alendronate DC7PHRC Alendronate Hypogonadism [12]
Testosterone + ACYLINE DCDG6R9 ACYLINE Contraception [13]
Testosterone + Buspirone DCG1LI0 Buspirone Hypoactive Sexual Desire Disorder [14]
Testosterone + Anastrozole DCVOA4Q Anastrozole Aging [10]
Testosterone + Finasteride DCYEQ44 Finasteride Male Hypogonadism [15]
Testosterone + Dutasteride DC1IGM6 Dutasteride Contraception [16]
Testosterone + ACYLINE DCFNP3R ACYLINE Insulin Resistance [17]
Leuprolide + Testosterone DC4L1H1 Leuprolide Contraception [18]
Testosterone + ACYLINE DC4LSZU ACYLINE Gonadotropin Deficiency [19]
Testosterone + Lynestrenol DCALIJ0 Lynestrenol Gender Dysphoria [20]
Testosterone + Ibutilide DC1S7B9 Ibutilide Long QT Syndrome [21]
------------------------------------------------------------------------------------
⏷ Show the Full List of 17 DrugCom(s)

References

1 Testosterone FDA Label
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2858).
3 ARDANA ANNOUNCES PHASE I RESULTS FOR TESTOSTERONE CREAM. FDAnews report.
4 Molecular mechanism of androgen action. Trends Endocrinol Metab. 1998 Oct 1;9(8):317-24.
5 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6 ClinicalTrials.gov (NCT02269072) Testosterone Regulation of the Natriuretic Peptide System
7 ClinicalTrials.gov (NCT01160328) Influence of Male Hormones on Regional Fat Metabolism
8 ClinicalTrials.gov (NCT00089843) Bone Loss in Women With Anorexia Nervosa
9 ClinicalTrials.gov (NCT01432665) Lybrido for Female Sexual Dysfunction
10 ClinicalTrials.gov (NCT00309855) Testosterone-Driven Growth-Hormone (GH) Secretion in Aging Men
11 ClinicalTrials.gov (NCT00891228) Study of the Safety, and Sperm and Gonadotropin Suppression of a Contraceptive Gel in Normal Men
12 ClinicalTrials.gov (NCT01460654) Testosterone and Alendronate in Hypogonadal Men
13 ClinicalTrials.gov (NCT00663793) ORAL T-6: Oral Androgens in Man-6
14 ClinicalTrials.gov (NCT01743235) Lybridos in Pre- and Postmenopausal Women With Hypoactive Sexual Desire Disorder Due to Maladaptive Activation of Sexual Inhibitory Systems
15 ClinicalTrials.gov (NCT00475501) 5-Alpha Reductase and Anabolic Effects of Testosterone
16 ClinicalTrials.gov (NCT00399165) Oral Androgens in Man-4: (Short Title: Oral T-4)
17 ClinicalTrials.gov (NCT01686828) T-IR- Study to Understand the Effects of Testosterone and Estrogen on the Body's Response to the Hormone Insulin
18 ClinicalTrials.gov (NCT00161421) Oral Androgens in Man-3 (ORAL T-3) Pharmacokinetics of Oral Testosterone
19 ClinicalTrials.gov (NCT02147964) ITT-5 Mechanisms of Spermatogenesis. U.S. National Institutes of Health.
20 ClinicalTrials.gov (NCT02715232) Effects of Sex Steroids on the Serotonin System
21 ClinicalTrials.gov (NCT04675788) Novel Approaches for Minimizing Drug-Induced QT Interval Lengthening