Details of the Drug Combinations

General Information of This Drug (ID: DM8EVK5)

Drug Name

Wortmannin DM8EVK5

Synonyms

wortmannin; 19545-26-7; Wartmannin; KY 12420; Antibiotic SL-2052; SL-2052; UNII-XVA4O219QW; NSC221019; XVA4O219QW; MLS002703028; CHEMBL428496; CHEBI:52289; Wortmannin, 98%; Pi 3-Kinase Inhibitor; NSC 627609; BRN 0067676; (1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-[(methyloxy)methyl]-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Terminated	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Wortmannin + Ruxolitinib	DCL5LE5	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
Wortmannin + Panobinostat	DCZ8IMS	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Wortmannin + Marizomib	DC88JPN	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Wortmannin + Idarubicin	DCE88B8	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6060).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.