Details of the Drug Combinations

General Information of This Drug (ID: DM8HJX6)

Drug Name

Tipranavir DM8HJX6

Synonyms

Aptivus; TPV; PNU 140690; U 140690; Aptivus (Boehringer Ingelheim); Aptivus (TN); Aptivus(TM); PNU-140690; PNU-140690E; Tipranavir (INN); U-140690; N-[3-[(1R)-1-[(2R)-6-hydroxy-4-oxo-2-phenethyl-2-propyl-3H-pyran-5-yl]propyl]phenyl]-5-(trifluoromethyl)pyridine-2-sulfonamide; N-(3-{(1R)-1-[(6R)-4-HYDROXY-2-OXO-6-PHENETHYL-6-PROPYL-5,6-DIHYDRO-2H-PYRAN-3-YL]PROPYL}PHENYL)-5-(TRIFLUOROMETHYL)-2-PYRIDINESULFONAMIDE

Indication

Disease Entry	ICD 11	Status	REF
Human immunodeficiency virus infection	1C62	Approved	[1]
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Therapeutic Class

Anti-HIV Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Tipranavir + Ritonavir	DC4RNB0	Ritonavir	HIV Infections	[2]
Tipranavir + Rosuvastatin	DCS97YB	Rosuvastatin	HIV Infections	[3]
Enfuvirtide + Tipranavir	DCCD494	Enfuvirtide	HIV Infections	[4]
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References

1	Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2	ClinicalTrials.gov (NCT00531206) Observational Non-interventional Study (Anwendungsbeobachtung) With Aptivus (Tipranavir) in HIV-infected Patients.
3	ClinicalTrials.gov (NCT00344123) Pharmacokinetic (PK) Study of Single-dose Rosuvastatin and Tipranavir/Ritonavir in Healthy Subjects
4	ClinicalTrials.gov (NCT00440271) SPRING: Safety, Efficacy, Pharmacokinetics of tipRanavir/r IN Race/Gender HIV+ Patients Randomized to TDM or SoC