Details of the Drug Combinations

General Information of This Drug (ID: DM8K5IF)

Drug Name

E7850 DM8K5IF

Synonyms

Irofulven

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
E7850 + Oxaliplatin	DCSKVK5	Oxaliplatin	Liver Cancer	[2]
E7850 + Docetaxel	DCOHOB2	Docetaxel	Solid tumour/cancer	[3]
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References

1	Irofulven induces replication-dependent CHK2 activation related to p53 status. Biochem Pharmacol. 2007 Feb 15;73(4):469-80.
2	ClinicalTrials.gov (NCT00374660) Study of Irofulven in Combination With Oxaliplatin in Patients With Advanced Solid Tumors
3	MGI PHARMA Initiates Drug Combination Trial of Irofulven and Taxotere in Patients With Advanced Cancers; Phase 1 Dose-Escalating Trial to Evaluate Novel Combination Therapy. 2001 Business Wire