Details of the Drug Combinations

General Information of This Drug (ID: DM8TUPF)

Drug Name

Milrinone DM8TUPF

Synonyms

Corotrop; Corotrope; Milrila; Milrinona; Milrinonum; Primacor; Milrinona [Spanish]; Milrinonum [Latin]; M 4659; M1663; YM 018; MILRINONE LACTATE IN DEXTROSE 5% IN PLASTIC CONTAINER; Milrila (TN); PRIMACOR IN DEXTROSE 5% IN PLASTIC CONTAINER; Primacor (TN); WIN 47203-2; Win-47203; Milrinone [USAN:BAN:INN]; Win-47203-2; Milrinone (JAN/USAN/INN); 1,6-Dihydro-2-methyl-6-oxo(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4′-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-(3,4'-bipyridine)-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-3,4-bipyridine-5-carbonitrile; 1,6-Dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile; 111GE027; 2-methyl-6-oxo-1,6-dihydro-3,4'-bipyridine-5-carbonitrile; 3-Cyano-6-methyl-5-(4-pyridyl)-2-pyridone; 6-Methyl-5-(4-pyridyl)-2-pyridone-3-carbonitrile; 6-methyl-2-oxo-5-pyridin-4-yl-1H-pyridine-3-carbonitrile

Indication

Disease Entry	ICD 11	Status	REF
Congestive heart failure	BD10	Approved	[1]
Cardiomyopathy	BC43	Investigative	[2]
------------------------------------------------------------------------------------

Therapeutic Class

Cardiotonic Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Esmolol + Milrinone	DCZNSYY	Esmolol	Myocardial Reperfusion Injury	[3]
Sildenafil + Milrinone	DC4TVFH	Sildenafil	Pulmonary Hypertension	[4]
Milrinone + Dobutamine	DC00C8V	Dobutamine	Shock, Cardiogenic	[5]
------------------------------------------------------------------------------------

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5225).
2	Milrinone FDA Label
3	ClinicalTrials.gov (NCT02098629) Concomitant Milrinone and Esmolol Treatment in Patients With Acute Myocardial Infarction
4	ClinicalTrials.gov (NCT02595541) Oral Sildenafil and Intravenous Milrinone on Postoperative Pulmonary Hypertension
5	ClinicalTrials.gov (NCT05267886) CAPITAL DOREMI 2: Inotrope Versus Placebo Therapy for Cardiogenic Shock