Details of the Drug Combinations

General Information of This Drug (ID: DM91LGU)

Drug Name

Abexinostat DM91LGU

Synonyms

PCI-24781; 783355-60-2; ABEXINOSTAT; PCI 24781; CRA-024781; CRA 024781; UNII-IYO470654U; 3-((dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)phenoxy)ethyl)benzofuran-2-carboxamide; CRA-02478; Abexinostat(PCI-24781); PCI-24781 (Abexinostat); Abexinostat (PCI-24781); IYO470654U; 3-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide; 3-((Dimethylamino)methyl)-N-(2-(4-(hydroxycarbamoyl)-phenoxy)ethyl)benzofuran-2-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Follicular lymphoma	2A80	Phase 3	[1]
Renal cell carcinoma	2C90	Phase 3	[2]
Acute myeloid leukaemia	2A60	Phase 2	[1]
Breast cancer	2C60-2C65	Phase 2	[1]
Diffuse large B-cell lymphoma	2A81	Phase 2	[1]
Gynecologic cancer	2F33-2F76	Phase 2	[1]
Peripheral T-cell lymphoma	2A90.C	Phase 2	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

22 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Abexinostat + DZNep	DCS2HYP	DZNep	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Trametinib	DCE8PR5	Trametinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Carfilzomib	DC3QJ8L	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Prochlorperazine	DCU3IRF	Prochlorperazine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + RTB101	DCCE1ZT	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Gemcitabine	DCGCFJX	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + CA4P	DCA47F5	CA4P	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Daporinad	DC8PB73	Daporinad	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + AG-881	DC8PGIS	AG-881	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Mebendazole	DCM6EPY	Mebendazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + CF102	DC11TYY	CF102	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + BMS-754807	DCS2NF4	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Rotenone	DCMA4BF	Rotenone	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Abexinostat + Doxorubicin	DC9ET99	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
ABT-199 + Abexinostat	DCIZZQS	ABT-199	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
BMS-754807 + Abexinostat	DCJ48NO	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Carfilzomib + Abexinostat	DC4BEMG	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Doxorubicin + Abexinostat	DC0RJQ6	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Mitomycin + Abexinostat	DC90B5Y	Mitomycin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
RTB101 + Abexinostat	DCF3SL2	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
THZ1 + Abexinostat	DC3CMCA	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
Trametinib + Abexinostat	DCCGPAR	Trametinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[4]
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⏷ Show the Full List of 22 DrugCom(s)

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Abexinostat + Temozolomide	DC3YZN1	Temozolomide	Recurrent High Grade Glioma	[5]
Abexinostat + Ibrutinib	DCU9N9T	Ibrutinib	Diffuse Large B-cell Lymphoma	[6]
Abexinostat + Pazopanib	DCTFW03	Pazopanib	Renal Cell Carcinoma	[2]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	ClinicalTrials.gov (NCT03592472) A Study of Pazopanib With or Without Abexinostat in Patients With Locally Advanced or Metastatic Renal Cell Carcinoma (RENAVIV). U.S. National Institutes of Health.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT05698524) A Study of Temodar With Abexinostat (PCI-24781) for Patients With Recurrent Glioma
6	ClinicalTrials.gov (NCT03939182) Abexinostat and Ibrutinib in Diffuse Large B-cell Lymphoma and Mantle Cell Lymphoma