Details of the Drug Combinations

General Information of This Drug (ID: DM9BI7M)

Drug Name

Duloxetine DM9BI7M

Synonyms

Yentreve; LY 248686; Cymbalta (TN); Duloxetine (INN); Duloxetine [INN:BAN]; Yentreve (TN); Duloxetine, (+)-isomer; (3S)-N-methyl-3-(1-naphthyloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-(naphthalen-1-yloxy)-3-(2-thienyl)propan-1-amine; (3S)-N-methyl-3-naphthalen-1-yloxy-3-thiophen-2-ylpropan-1-amine; (S)-Duloxetine; (S)-N-Methyl-gamma-(1-naphthalenyloxy)-2-thiophenepropanamine

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[1]
Major depressive disorder	6A70.3	Approved	[2]
Stress urinary incontinence	MF50.20	Approved	[2]
Traumatic brain injury	NA07.Z	Approved	[2]
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Therapeutic Class

Antidepressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Duloxetine + Pregabalin	DCH4EHW	Pregabalin	Central Sensitisation	[3]
Duloxetine + Desvenlafaxine	DCZ4CHL	Desvenlafaxine	Depression	[4]
Duloxetine + Pregabalin	DCB5CMJ	Pregabalin	Fibromyalgia	[5]
Duloxetine + Tramadol	DCG4Z0O	Tramadol	Diabetic Polyneuropathy	[6]
Duloxetine + Tramadol	DCS0HSJ	Tramadol	Cancer Pain	[7]
Duloxetine + Warfarin	DCUD2H7	Warfarin	Anticoagulant Effect of Warfarin When Taken With Duloxetine.	[8]
Gabapentin + Duloxetine	DC93237	Gabapentin	Diabetic Neuropathic Pain	[9]
Sertraline + Duloxetine	DCLRJHM	Sertraline	PTSD	[10]
Propranolol + Duloxetine	DC8NCAP	Propranolol	Low Back Pain	[11]
Duloxetine + Naproxen	DC1SVVF	Naproxen	Back Pain, Low	[12]
Duloxetine + Escitalopram	DCNHSBC	Escitalopram	Post Traumatic Stress Disorder	[13]
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⏷ Show the Full List of 11 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 202).
2	Duloxetine FDA Label
3	ClinicalTrials.gov (NCT05020600) The Effect of Central Sensitization on Treatment Response in Patients With Fibromyalgia
4	ClinicalTrials.gov (NCT02320240) Serotonin-norepinephrine Reuptake Inhibitors and Acute Kidney Injury
5	ClinicalTrials.gov (NCT01268631) Mechanism-based Choice of Therapy: Can Treatments Success in Fibromyalgia Patients be Coupled to Psychophysical Pain Modulation Profile?
6	ClinicalTrials.gov (NCT01116531) Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin
7	ClinicalTrials.gov (NCT05311774) Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain
8	ClinicalTrials.gov (NCT00533026) Duloxetine - Warfarin Pharmacodynamic Study
9	ClinicalTrials.gov (NCT00619983) Three Way Interaction Between Gabapentin, Duloxetine, and Donepezil in Patients With Diabetic Neuropathy
10	ClinicalTrials.gov (NCT05930912) Psychiatric Orders in Psychoanalytic Treatment of ASD
11	ClinicalTrials.gov (NCT03364075) Genetic Variants Associated With Low Back Pain and Their Response to Treatment With Duloxetine or Propranolol
12	ClinicalTrials.gov (NCT05851976) Duloxetine for LBP
13	ClinicalTrials.gov (NCT04697693) Antidepressant Response in Older Adults With Comorbid PTSD and MDD